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- 저자 : Xue Huashi (검색결과 2 건)
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Pengli Li,Chunxia Li,Yiting Xue,Xia Zhao,Guangli Yu,Huashi Guan 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Propylene glycol alginate sodium sulfate (PSS) is a kind of sulfated polysaccharide that is derived from seaweed extract sodium alginate through hydrolysis and esterification. PSS is a heparinoid drug, mainly used for the prophylaxis and treatment of ischemic cardiovascular and cerebrovascular diseases in clinical in China. In order to develop and utilize PSS better, a new fluorescent labeling method was established to study the pharmacokinetic parameters of PSS. A rapid and sensitive fluorescent labeling method was developed and validated for microanalysis of marine sulfated polysaccharide PSS in rat plasma. 1, 6-diaminohexane was chosen as the spacer arm to link PSS with FITC. The fluorescent labeled PSS (F-PSS) was identified through its spectroscopic properties. The labeling method showed good linearity, precision, recovery and stability, which suggested that it was sensitive and reliable. The pharmacokinetic results showed that the absolute bioavailability of F-PSS was 8.39% and the other parameters were tested after oral and intravenous administration of F-PSS. The labeling method could be successfully applied to the investigation of the absorption and metabolism of PSS in future. Moreover, the labeling method could be also applied to pharmacokinetic studies of other polysaccharides in biological samples.
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Lu Ming,Li Min,Luo Tao,Li Yongsui,Wang Mingxin,Xue Huashi,Zhang Mengchen,Chen Qiu 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Treating large-volume bone defects (LVBD) remains a challenge for orthopedics and maxillofacial surgeons globally. Objective The present study was to aimed investigate the role of Beta-naphthofl avone (BNF) a synthetic fl avonoid on differentiation of osteoblast of human adipose derived stem cells. Results BNF at 1 μM showed a signifi cantly increased ALP activity and rate of cell proliferation compared to control on the 3rd, 7th and 14th day. Also, it was observed that, BNF at 1 μM resulted in signifi cantly increased expression of BSP. On the 14th day of treatment, BNF at all the three treatments resulted in increased levels of OCN. Also, extracellular matrix mineralization levels were recorded to be highest for BNF 1 μM. The levels of Runx2 were higher in 1 μM treated group on the 3rd day compared to other, whereas in contrast the levels were lower on the 7th and 14th day compared to control. BNF at all the three treatments caused a signifi cant decrease in levels of pSTAT3, C/EBP-α and PPAR-γ levels. Conclusion BNF treatment resulted in increased diff erentiation of osteoblast of hASCs by targeting STAT3 pathway.
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