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Advances in Smartphone-Based Point-of-Care Diagnostics
Xiayu Xu,Akay, Altug,Huilin Wei,ShuQi Wang,Pingguan-Murphy, Belinda,Erlandsson, Bjorn-Erik,XiuJun Li,WonGu Lee,Jie Hu,Lin Wang,Feng Xu IEEE 2015 Proceedings of the Institute of Electrical and Ele Vol.103 No.2
<P>Point-of-care (POC) diagnostics is playing an increasingly important role in public health, environmental monitoring, and food safety analysis. Smartphones, alone or in conjunction with add-on devices, have shown great capability of data collection, analysis, display, and transmission, making them popular in POC diagnostics. In this article, the state-of-the-art advances in smartphone-based POC diagnostic technologies and their applications in the past few years are outlined, ranging from in vivo tests that use smartphone's built-in/external sensors to detect biological signals to in vitro tests that involves complicated biochemical reactions. Novel techniques are illustrated by a number of attractive examples, followed by a brief discussion of the smartphone's role in telemedicine. The challenges and perspectives of smartphone-based POC diagnostics are also provided.</P>
Mengjie Xu,Feng Xiao,Mengshi Wang,Tingxu Yan,Huilin Yang,Bo Wu,Kaishun Bi,Ying Jia 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.2
Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.
LncRNA PVT1 upregulates FBN1 by sponging miR-30b-5p to aggravate pulpitis
Li Yuanyuan,Li Shuangshuang,Li Ruijing,Xu Huilin 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Pulpitis is a disease mainly caused by bacterial infection. Long noncoding RNAs (lncRNAs) infl uence the advancement of pulpitis. In this paper, we reconnoitered the characters of lncRNA plasmacytoma variant translocation 1 (PVT1) in pulpitis. Objective PVT1, microRNA-30b-5p (miR-30b-5p) and fi brillin 1 (FBN1) levels were identifi ed by qRT-PCR and western blot. In addition, the cell functions were scrutinized. Additionally, the link between miR-30b-5p and PVT1 or FBN1 was identifi ed by dual-luciferase reporter assay. Result The contents of PVT1 and FBN1 were augmented, but the miR-30b-5p level was declined in pulpitis. Knockdown of PVT1 enhanced cell proliferation and cell vitality, whereas inhibited cell infl ammatory reaction in HDPFs under LPS stimulation. In mechanism, PVT1 acted as a miR-30b-5p sponge to adjust the content of FBN1. Moreover, miR-30b-5p mediated LPS-mediated repression of proliferation and promotion of infl ammatory reaction HDPFs by FBN1. Conclusion PVT1 expedited the improvement of pulpitis via miR-30b-5p/FBN1.
Development of Enzymatic Recombinase Amplification Assays for the Rapid Visual Detection of HPV16/18
Ding Ning,Qi Wanwan,Wu Zihan,Zhang Yaqin,Xu Ruowei,Lin Qiannan,Zhu Jin,Zhang Huilin 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.8
Human papillomavirus (HPV) types 16 and 18 are the major causes of cervical lesions and are associated with 71% of cervical cancer cases globally. However, public health infrastructures to support cervical cancer screening may be unavailable to women in low-resource areas. Therefore, sensitive, convenient, and cost-efficient diagnostic methods are required for the detection of HPV16/18. Here, we designed two novel methods, real-time ERA and ERA-LFD, based on enzymatic recombinase amplification (ERA) for quick point-of-care identification of the HPV E6/E7 genes. The entire detection process could be completed within 25 min at a constant low temperature (35–43°C), and the results of the combined methods could be present as the amplification curves or the bands presented on dipsticks and directly interpreted with the naked eye. The ERA assays evaluated using standard plasmids carrying the E6/E7 genes and clinical samples exhibited excellent specificity, as no cross-reaction with other common HPV types was observed. The detection limits of our ERA assays were 100 and 101 copies/μl for HPV16 and 18 respectively, which were comparable to those of the real-time PCR assay. Assessment of the clinical performance of the ERA assays using 114 cervical tissue samples demonstrated that they are highly consistent with real-time PCR, the gold standard for HPV detection. This study demonstrated that ERA-based assays possess excellent sensitivity, specificity, and repeatability for HPV16 and HPV18 detection with great potential to become robust diagnostic tools in local hospitals and field studies.