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The application of modified isochronal well test in a low-permeability condensate gas field
Zhaojing Zhou,Xiuwei Wang,Xue Miao,Kangning Qian,Lijian Li,Peng Xu,Xiuqin Lu 한국자원공학회 2019 Geosystem engineering Vol.22 No.6
The modified isochronal well test is a deliverability test method suitable for gas wells in low-permeability gas reservoirs. Generally, the absolute open flow of gas wells is determined by modified isochronal well test, thereby establishing a reasonable working system for gas wells. It is also possible to obtain gas layer physical parameters, gas reservoir engineering parameters, heterogeneity, boundary characteristics, etc. In this paper, the actual test data of a condensate gas field are applied. By modified isochronal well test analysis, not only the deliverability equation of the gas well is obtained, but also the absolute open flow is determined. At the same time, the formation parameters such as reservoir permeability and skin factor are obtained and the acidification effect is evaluated.
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Guanglei Zhao,Zhao Wang,Xiuwei Fu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4
This paper investigates the event-triggered consensus problem of multi-agent systems with uncertainties and input saturation. First, a fully distributed robust consensus low-gain feedback control strategy is proposed, in which some global information, such as the communication graph and the scale of network, is not needed. Then, by defining an internal dynamic variable to memory the past state, an adaptive dynamic event-triggering mechanism is proposed, which contributes to reducing the usage of communication resources and also does not rely on any global information. Furthermore, Lyapunov-based consensus analysis results are presented, and it is also formally shown that Zeno behavior can be excluded with the proposed consensus protocols. Finally, a numerical example is provided to illustrate the effectiveness of the proposed results.
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Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect
Pang Xiaogang,Xu Yifan,Xie Shuoxin,Zhang Tianshu,Cong Lin,Qi Yuchen,Liu Lubing,Li Qingjun,Mo Mei,Wang Guimei,Du Xiuwei,Shen Hui,Li Yuanyuan 한국뇌신경과학회 2023 Experimental Neurobiology Vol.32 No.4
Sleep deprivation (SD) has a profound impact on the central nervous system, resulting in an array of mood disorders, including depression and anxiety. Despite this, the dynamic alterations in neuronal activity during sleep deprivation have not been extensively investigated. While some researchers propose that sleep deprivation diminishes neuronal activity, thereby leading to depression. Others argue that short-term sleep deprivation enhances neuronal activity and dendritic spine density, potentially yielding antidepressant effects. In this study, a two-photon microscope was utilized to examine the calcium transients of anterior cingulate cortex (ACC) neurons in awake SD mice in vivo at 24-hour intervals. It was observed that SD reduced the frequency and amplitude of Ca2+ transients while increasing the proportions of inactive neurons. Following the cessation of sleep deprivation, neuronal calcium transients demonstrated a gradual recovery. Moreover, whole-cell patch-clamp recordings revealed a significant decrease in the frequency of spontaneous excitatory post-synaptic current (sEPSC) after SD. The investigation also assessed several oxidative stress parameters, finding that sleep deprivation substantially elevated the level of malondialdehyde (MDA), while simultaneously decreasing the expression of Nuclear Factor erythroid 2-Related Factor 2 (Nrf2) and activities of Superoxide dismutase (SOD) in the ACC. Importantly, the administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation. These findings indicate that the calcium transients of ACC neurons experience a continuous decline during sleep deprivation, a process that is reversible. GA may serve as a potential candidate agent for the prevention and treatment of cognitive impairment induced by sleep deprivation.
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