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Emerging 3D bioprinting applications in plastic surgery
Yang Pu,Ju Yikun,Hu Yue,Xie Xiaoyan,Fang Bairong,Lei Lanjie 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Plastic surgery is a discipline that uses surgical methods or tissue transplantation to repair, reconstruct and beautify the defects and deformities of human tissues and organs. Three-dimensional (3D) bioprinting has gained widespread attention because it enables fine customization of the implants in the patient's surgical area preoperatively while avoiding some of the adverse reactions and complications of traditional surgical approaches. In this paper, we review the recent research advances in the application of 3D bioprinting in plastic surgery. We first introduce the printing process and basic principles of 3D bioprinting technology, revealing the advantages and disadvantages of different bioprinting technologies. Then, we describe the currently available bioprinting materials, and dissect the rationale for special dynamic 3D bioprinting (4D bioprinting) that is achieved by varying the combination strategy of bioprinting materials. Later, we focus on the viable clinical applications and effects of 3D bioprinting in plastic surgery. Finally, we summarize and discuss the challenges and prospects for the application of 3D bioprinting in plastic surgery. We believe that this review can contribute to further development of 3D bioprinting in plastic surgery and provide lessons for related research. Graphical Abstract
Xie, T.,Cho, Y.B.,Wang, K.,Huang, D.,Hong, H.K.,Choi, Y.L.,Ko, Y.H.,Nam, D.H.,Jin, J.,Yang, H.,Fernandez, J.,Deng, S.,Rejto, P.A.,Lee, W.Y.,Mao, M. Academic Press 2014 Genomics Vol.104 No.4
Colorectal cancer (CRC) patients have poor prognosis after formation of distant metastasis. Understanding the molecular mechanisms by which genetic changes facilitate metastasis is critical for the development of targeted therapeutic strategies aimed at controlling disease progression while minimizing toxic side effects. A comprehensive portrait of somatic alterations in CRC and the changes between primary and metastatic tumors has yet to be developed. We performed whole genome sequencing of two primary CRC tumors and their matched liver metastases. By comparing to matched germline DNA, we catalogued somatic alterations at multiple scales, including single nucleotide variations, small insertions and deletions, copy number aberrations and structural variations in both the primary and matched metastasis. We found that the majority of these somatic alterations are present in both sites. Despite the overall similarity, several de novo alterations in the metastases were predicted to be deleterious, in genes including FBXW7, DCLK1 and FAT2, which might contribute to the initiation and progression of distant metastasis. Through careful examination of the mutation prevalence among tumor cells at each site, we also proposed distinct clonal evolution patterns between primary and metastatic tumors in the two cases. These results suggest that somatic alterations may play an important role in driving the development of colorectal cancer metastasis and present challenges and opportunities when considering the choice of treatment.
SYNTHESIS AND PROPERTY OF MULTIFUNCTIONAL Fe3O4@SiO2@CeO2@Au COMPOSITE MICROSPHERES
YANG WANG,HAORAN SUN,TONG ZHANG,ANJIAN XIE 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.6
In this paper, Fe3O4@SiO2@CeO2@Au core/shell microspheres were synthesized through hydrolysis and solvothermal processes. The results indicated that the magnetic Fe3O4 cores were well wrapped by the coating layer of SiO2/CeO2 with a thickness of 50 nm, and Au nanoparticles with 35 nm in diameter were attached on the shell. The microspheres showed a monodispersity and superparamagnetism. The composites showed excellent ability to absorb a wide range of wavelengths including visible and NIR region (from 250 nm to 800nm), making it a potential full solar spectrum response photocatalyst for sunlight applications.
Multiscale Spatial Position Coding under Locality Constraint for Action Recognition
Yang, Jiang-feng,Ma, Zheng,Xie, Mei The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.4
– In the paper, to handle the problem of traditional bag-of-features model ignoring the spatial relationship of local features in human action recognition, we proposed a Multiscale Spatial Position Coding under Locality Constraint method. Specifically, to describe this spatial relationship, we proposed a mixed feature combining motion feature and multi-spatial-scale configuration. To utilize temporal information between features, sub spatial-temporal-volumes are built. Next, the pooled features of sub-STVs are obtained via max-pooling method. In classification stage, the Locality-Constrained Group Sparse Representation is adopted to utilize the intrinsic group information of the sub-STV features. The experimental results on the KTH, Weizmann, and UCF sports datasets show that our action recognition system outperforms the classical local ST feature-based recognition systems published recently.
Single Nanorod Devices for Battery Diagnostics: A Case Study on LiMn<sub>2</sub>O<sub>4</sub>
Yang, Yuan,Xie, Chong,Ruffo, Riccardo,Peng, Hailin,Kim, Do Kyung,Cui, Yi American Chemical Society 2009 NANO LETTERS Vol.9 No.12
<P>This paper presents single nanostructure devices as a powerful new diagnostic tool for batteries with LiMn<SUB>2</SUB>O<SUB>4</SUB> nanorod materials as an example. LiMn<SUB>2</SUB>O<SUB>4</SUB> and Al-doped LiMn<SUB>2</SUB>O<SUB>4</SUB> nanorods were synthesized by a two-step method that combines hydrothermal synthesis of β-MnO<SUB>2</SUB> nanorods and a solid state reaction to convert them to LiMn<SUB>2</SUB>O<SUB>4</SUB> nanorods. λ-MnO<SUB>2</SUB> nanorods were also prepared by acid treatment of LiMn<SUB>2</SUB>O<SUB>4</SUB> nanorods. The effect of electrolyte etching on these LiMn<SUB>2</SUB>O<SUB>4</SUB>-related nanorods is investigated by both SEM and single-nanorod transport measurement, and this is the first time that the transport properties of this material have been studied at the level of an individual single-crystalline particle. Experiments show that Al dopants reduce the dissolution of Mn<SUP>3+</SUP> ions significantly and make the LiAl<SUB>0.1</SUB>Mn<SUB>1.9</SUB>O<SUB>4</SUB> nanorods much more stable than LiMn<SUB>2</SUB>O<SUB>4</SUB> against electrolyte etching, which is reflected by the magnification of both size shrinkage and conductance decrease. These results correlate well with the better cycling performance of Al-doped LiMn<SUB>2</SUB>O<SUB>4</SUB> in our Li-ion battery tests: LiAl<SUB>0.1</SUB>Mn<SUB>1.9</SUB>O<SUB>4</SUB> nanorods achieve 96% capacity retention after 100 cycles at 1C rate at room temperature, and 80% at 60 °C, whereas LiMn<SUB>2</SUB>O<SUB>4</SUB> shows worse retention of 91% at room temperature, and 69% at 60 °C. Moreover, temperature-dependent <I>I</I>−<I>V</I> measurements indicate that the sharp electronic resistance increase due to charge ordering transition at 290 K does not appear in our LiMn<SUB>2</SUB>O<SUB>4</SUB> nanorod samples, suggesting good battery performance at low temperature.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2009/nalefd.2009.9.issue-12/nl902315u/production/images/medium/nl-2009-02315u_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl902315u'>ACS Electronic Supporting Info</A></P>
Yang, Bin,Xiao, Wenxun,Xie, Fan,Zhang, Bo,Chen, Yanfeng,Qiu, Dongyuan The Korean Institute of Power Electronics 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.9
The min-projection strategy (MPS) is a switching rule with better convergence speed, which can improve the dynamic characteristics of three-phase grid-connected inverters. However, the grid-connected current harmonics of the system are large when the MPS is used directly in the digital control framework due to the limitations of the sampling frequency. To solve this problem, an improved min-projection strategy is proposed in this paper by introducing a zero voltage vector to the control. First, the non-zero voltage vector is selected through the switching law function of the MPS. Then the time occupied by the non-zero voltage vector and the zero voltage vector can be obtained through an error function, which is established by the principle of minimum current error. Finally, the switching signal can be obtained for control, based on the method of duty cycle modulation. This method can realize fast current tracking and current decoupling control, reduce the grid-connected current harmonics, and improve the steady state performance of the system without increasing costs. The effectiveness of the proposed method is verified by simulations and experimental results.