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- 저자 : Xie Lixin (검색결과 3 건)
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Lee, Byeongyong,Liu, Tianyuan,Kim, Sun Kyung,Chang, Hankwon,Eom, Kwangsup,Xie, Lixin,Chen, Shuo,Jang, Hee Dong,Lee, Seung Woo Elsevier 2017 Carbon Vol.119 No.-
<P>Silicon (Si) is an emerging anode material for rechargeable lithium-ion battery owing to its high theoretical capacity. However, Si-based anodes suffer from poor cycling stability because of its large volume change during lithiation/delithiation processes. Although nanostructured Si electrodes have significantly improved the cycling stability, the scale-up of these electrodes is another critical huddle for commercialization. To address these issues, we introduce a simple and scalable electrode fabrication process using low-cost submicron Si particles (<similar to 1 mu m) that was recycled from industrial Si waste. During the electrode fabrication, the submicron Si particles are encapsulated with 3D carbon matrix including a carbon coating on the Si particles and interconnected reduced graphene layers, which can effectively mitigate volume variation of the Si as well as support electrical conductivity. The submicron Si particle based electrodes exhibit a reversible capacity of 1192 mAh g(-1) at 100th cycle, retaining up to 84% of initial capacity. The introduced approach based on Si waste provides a new opportunity in fabricating sustainable and scalable Si-based anodes for high-capacity lithium-ion batteries. (C) 2017 Elsevier Ltd. All rights reserved.</P>
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Khor, Wei-Boon,Prajna, Venkatesh N.,Garg, Prashant,Mehta, Jodhbir S.,Xie, Lixin,Liu, Zuguo,Padilla, Ma. Dominga B.,Joo, Choun-Ki,Inoue, Yoshitsugu,Goseyarakwong, Panida,Hu, Fung-Rong,Nishida, Kohji,Ki Elsevier 2018 American journal of ophthalmology Vol.195 No.-
<P><B>Purpose</B></P> <P>To survey the demographics, risk factors, microbiology, and outcomes for infectious keratitis in Asia.</P> <P><B>Design</B></P> <P>Prospective, nonrandomized clinical study.</P> <P><B>Methods</B></P> <P>Thirteen study centers and 30 sub-centers recruited consecutive subjects over 12-18 months, and performed standardized data collection. A microbiological protocol standardized the processing and reporting of all isolates. Treatment of the infectious keratitis was decided by the managing ophthalmologist. Subjects were observed for up to 6 months. Main outcome measures were final visual acuity and the need for surgery during infection.</P> <P><B>Results</B></P> <P>A total of 6626 eyes of 6563 subjects were studied. The majority of subjects were male (n = 3992). Trauma (n = 2279, 34.7%) and contact lens wear (n = 704, 10.7%) were the commonest risk factors. Overall, bacterial keratitis was diagnosed in 2521 eyes (38.0%) and fungal keratitis in 2166 eyes (32.7%). Of the 2831 microorganisms isolated, the most common were <I>Fusarium</I> species (n = 518, 18.3%), <I>Pseudomonas aeruginosa</I> (n = 302, 10.7%), and <I>Aspergillus flavus</I> (n = 236, 8.3%). Cornea transplantation was performed in 628 eyes to manage ongoing infection, but 289 grafts (46%) had failed by the end of the study. Moderate visual impairment (Snellen vision less than 20/60) was documented in 3478 eyes (53.6%).</P> <P><B>Conclusion</B></P> <P>Demographic and risk factors for infection vary by country, but infections occur predominantly in male subjects and are frequently related to trauma. Overall, a similar percentage of bacterial and fungal infections were diagnosed in this study. Visual recovery after infectious keratitis is guarded, and corneal transplantation for active infection is associated with a high failure rate.</P>
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Hou Fei,Wang Huan,Zheng Kun,Yang Wenting,Xiao Kun,Rong Zihan,Xiao Junjie,Li Jing,Cheng Baihe,Tang Li,Xie Lixin 대한면역학회 2023 Immune Network Vol.23 No.3
In acute lung injury, two subsets of lung macrophages exist in the alveoli: tissue-resident alveolar macrophages (AMs) and monocyte-derived alveolar macrophages (MDMs). However, it is unclear whether these 2 subsets of macrophages have different functions and characteristics during the recovery phase. RNA-sequencing of AMs and MDMs from the recovery period of LPS-induced lung injury mice revealed their differences in proliferation, cell death, phagocytosis, inflammation and tissue repair. Using flow cytometry, we found that AMs showed a higher ability to proliferate, whereas MDMs expressed a larger amount of cell death. We also compared the ability of phagocytosing apoptotic cells and activating adaptive immunity and found that AMs have a stronger ability to phagocytose, while MDMs are the cells that activate lymphocytes during the resolving phase. By testing surface markers, we found that MDMs were more prone to the M1 phenotype, but expressed a higher level of pro-repairing genes. Finally, analysis of a publicly available set of single-cell RNA-sequencing data on bronchoalveolar lavage cells from patients with SARS-CoV-2 infection validated the double-sided role of MDMs. Blockade of inflammatory MDM recruitment using CCR2−/− mice effectively attenuates lung injury. Therefore, AMs and MDMs exhibited large differences during recovery. AMs are long-lived M2-like tissue-resident macrophages that have a strong ability to proliferate and phagocytose. MDMs are a paradoxical group of macrophages that promote the repair of tissue damage despite being strongly pro-inflammatory early in infection, and they may undergo cell death as inflammation fades. Preventing the massive recruitment of inflammatory MDMs or promoting their transition to pro-repairing phenotype may be a new direction for the treatment of acute lung injury.
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