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The Prebiotic Lactosucrose Modulates Gut Metabolites and Microbiota in Intestinal Inflammatory Rats
Xiaoli Zhou,Zheng Ruan,Xiaoliu Huang,Yan Zhou,Shiqiang Liu,Yulong Yin 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The effect of lactosucrose on the short chainfatty acid (SCFA) content, the intestinal flora, the acidity,and the amino nitrogen (NH3-N) content of the intestine ininflammatory bowel disease (IBD) rats was investigated. Dietary lactosucose supplementation increased amounts ofbeneficial bacteria and diminished amounts of pathogenicbacteria. Lactosucrose decreased the NH3-N content in cecaland colonic digesta, compared to inflammatory rats. Lactosucrose increased the acidity in the intestinal lumen,and the acetic acid, propionic acid, and butyric acidcontents in cecal and colonic digesta, compared toinflammatory rats. The butyrate content in the lactosucrosegroup was higher than for the inflammatory, sulfasalazine,and normal groups. Lactosucrose promoted beneficialintestinal health and prevented intestinal inflammation.