http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Woojun Kim (검색결과 95 건)
- 무료
- 기관 내 무료
- 유료
-
Kim, Seok-Ki,Im, Hyung Jun,Kim, Woojun,Kim, Tae-Sung,Hwangbo, Bin,Kim, Ho Jin Wolters Kluwer Health, Inc. All rights reserved. 2010 Clinical nuclear medicine Vol.35 No.2
PURPOSE:: F-18 fluorothymidine (FLT) PET/CT is considered more specific for malignancy than F-18 fluorodeoxyglucose (FDG) PET/CT. This case report presents F-18 FLT and F-18 FDG scans of a patient with neurosarcoidosis. MATERIALS AND METHODS:: We describe a 34-year-old man who presented with myelopathic symptoms and signs. The patient’s evaluation included serological tests for systemic autoimmunity, CSF analysis, magnetic resonance imaging of the spinal cord and brain, abdominal CT, whole-body F-18 FDG and F-18 FLT PET/CT, and high-resolution chest CT. The patient finally underwent transbronchial mediastinal lymph node biopsy for definite diagnosis. RESULTS:: The neurologic symptoms were relapsing and remitting. Magnetic resonance imaging demonstrated corresponding abnormal lesions in the spinal cord. Under a tentative diagnosis of multiple sclerosis, the patient was treated with beta-interferon, which showed no beneficial effect. Abdominal CT for evaluation of unexplained abdominal discomfort revealed abdominal lymphadenopathies. F-18 FDG PET/CT showed multiple symmetrical intense accumulations of F-18 FDG on mediastinal and abdominal lymph nodes, whereas only faint to mild F-18 FLT accumulations were observed. Biopsy of mediastinal lymph nodes indicated nontuberculous granulomatous disease. A final diagnosis of neurosarcoidosis was made, and his clinical symptoms and signs were markedly improved by immunosuppressive treatment. CONCLUSIONS:: Multiple F-18 FDG-avid lymphadenopathies with mild F-18 FLT uptake can be characteristic findings of sarcoidosis. The combination of F-18 FDG and F-18 FLT PET/CT can be helpful in differentiating granulomatous inflammatory diseases such as neurosarcoidosis from malignancy and in localizing the most appropriate biopsy site of active sarcoidosis.
-
Kim, Su-Hyun,Huh, So-Young,Kim, Woojun,Park, Min Su,Ahn, Suk-Won,Cho, Joong-Yang,Kim, Byung Jo,Kim, Ho Jin SAGE Publications 2013 Multiple sclerosis journal: clinical and laborator Vol.19 No.11
<P><B>Background:</B></P><P>Multiple sclerosis (MS) in Asia is thought to have different clinical characteristics from MS in Western countries; however, previous studies in Asia were performed without properly differentiating neuromyelitis optica (NMO) from MS.</P><P><B>Objectives:</B></P><P>To evaluate the clinical characteristics of MS in Korea after careful exclusion of potential explanations other than MS, particularly NMO spectrum disorder (NMOSD).</P><P><B>Methods:</B></P><P>This study is a retrospective review of consecutive MS patients attending five referral hospitals in Korea. All patients’ MS diagnoses were re-evaluated.</P><P><B>Results:</B></P><P>Of the 105 patients, 70 were female and 35 were male. The mean age of onset was 30.4 years and the mean disease duration was 5.4 years. On initial magnetic resonance imaging (MRI), 58% and 64% fulfilled the criteria for dissemination in space for the 2005 and 2010 McDonald criteria, respectively. Spinal cord lesions were observed in 78% of patients, primarily present as multiple small lesions with a mean length of 0.9 vertebral segments. The median time from disease onset to an Expanded Disability Status Scale 6 was 20 years.</P><P><B>Conclusions:</B></P><P>After careful exclusion of NMOSD, we found that the clinical pattern of MS in Korea does not fundamentally differ from that seen in Western countries.</P>
-
Brain abnormalities as an initial manifestation of neuromyelitis optica spectrum disorder
Kim, Woojun,Kim, Su-Hyun,Hyun Lee, Sang,Feng Li, Xue,Jin Kim, Ho SAGE Publications 2011 Multiple sclerosis journal: clinical and laborator Vol.17 No.9
<P> Background: Although brain abnormalities are being recognized more frequently in patients with neuromyelitis optica spectrum disorder (NMOSD), most brain lesions in previous reports have accompanied pre-existing NMOSD. Here, we describe clinical and imaging characteristics of patients with NMOSD who presented with brain symptoms as their first manifestation of the condition. </P><P> Methods: Anti-aquaporin-4 antibody was measured using cell-based assays and/or enzyme-linked immunosorbent assay in the sera of 257 patients with inflammatory diseases of the central nervous system who attended the multiple sclerosis clinic of the National Cancer Center, Korea, between May 2005 and December 2009. Eighty-three were seropositive, and 15 of these who presented with brain symptoms were included in this study. We retrospectively reviewed these individuals’ clinical and radiological findings. </P><P> Results: Patients with NMOSD were followed for a mean of 90 months. Median age at onset was 24 years (6-54 years) and there was a female preponderance (94%). The initial manifestation was classified into two groups according to clinical characteristics: encephalopathy mimicking acute disseminated encephalomyelitis or posterior reversible encephalopathy syndrome and characteristic brainstem symptoms such as intractable hiccup and vomiting. The majority of brain symptoms and lesions resolved. Intriguingly, eight patients (53%) experienced brain relapses that followed a similar pattern during the course of their disease. </P><P> Conclusion: It is important to recognize that NMO or NMOSD can initially present with brain symptoms. </P>
-
-
Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering
Kim, Su Hee,Hur, Woojune,Kim, Ji Eun,Min, Hye Jeong,Kim, Sukwha,Min, Hye Sook,Kim, Byeung Kyu,Kim, Soo Hyun,Choi, Tae Hyun,Jung, Youngmee Mary Ann Liebert 2015 Tissue engineering. Part A Vol.21 No.7
<P>The number of patients requiring flat bone transplantation continues to increase worldwide. Cell transplantation has been successfully applied clinically; however, it causes another defect site and the time requirements to harvest cells and expand them are considerable. In this study, KLD12/KLD12-SP (KLD12+KLD12-substance P [SP]) was designed to mimic endogenous tissue-healing processes. The structures of KLD12, KLD12-SP, and KLD12/KLD12-SP were observed by transmission electron microscopy and circular dichroism spectra. KLD12/KLD12-SP nanofibers (5-10?nm) were created under physiological conditions by formation of a β-sheet structure. The ability of mesenchymal stem cells (MSCs) to recruit KLD12/KLD12-SP was observed by using an in vivo fluorescence imaging system. Labeled human bone marrow stromal cells supplied via an intravenous injection were recruited to the scaffold containing KLD12/KLD12-SP. Polylactic acid/beta-tricalcium phosphate (PLA/β-TCP) scaffolds filled with KLD12/KLD12-SP were applied to repair calvarial defects. The composite constructs (groups: defect, PLA/β-TCP, PLA/β-TCP/KLD12, and PLA/β-TCP/KLD12/KLD12-SP) were implanted into rat defect sites. Bone tissue regeneration was evaluated by observing gross morphology by hematoxylin and eosin and Masson's trichrome staining at 12 and 24 weeks after surgery. Gross morphology showed that the defect site was filled with new tissue that was integrated with host tissue in the KLD12/KLD12-SP group. In addition, from the staining data, cells were recruited to the defect site and lacunae structures formed in the KLD12/KLD12-SP group. From these results, the PLA/β-TCP+KLD12/KLD12-SP composite construct was considered for enhancement of bone tissue regeneration without cell transplantation.</P>
-
Kim, Woojun,Min Su Park,,Sang Hyun Lee,,Kim, Su-Hyun,In Ja Jung,,Takahashi, Toshiyuki,Misu, Tatsuro,Fujihara, Kazuo,Ho Jin Kim, SAGE Publications 2010 Multiple sclerosis journal: clinical and laborator Vol.16 No.10
<P> Background: Although neuromyelitis optica has been traditionally regarded as a disease without brain involvement, brain abnormalities are not uncommon in patients with neuromyelitis optica-related disorders. </P><P> Methods: We aimed to characterize the brain magnetic resonance imaging (MRI) abnormalities in neuromyelitis optica spectrum disorder patients who are seropositive for anti-aquaporin-4 autoantibody (AQP4 Ab). Of 236 consecutive patients with inflammatory demyelinating central nervous system diseases, we retrospectively analyzed MRI characteristics of 78 patients who were seropositive for AQP4 Ab. </P><P> Results: For an average observational period of 6.3 years, 62 patients (79%) had brain lesions on MRI. Twenty-four patients (31%) had brain MRI abnormalities at the onset of disease, and 35 (45%) had symptomatic brain involvement. Characteristic brain MRI abnormalities were classified into five categories: (1) lesions involving corticospinal tracts (e.g. posterior limb of internal capsule and cerebral peduncle (44%); (2) extensive hemispheric lesions likely due to vasogenic edema (29%); (3) periependymal lesions surrounding aqueduct and the third and fourth ventricles (22%); (4) periependymal lesions surrounding lateral ventricles (40%); and (5) medullary lesions, often contiguous with cervical lesions (31%). Fifty-four patients (69%) showed at least one kind of brain abnormality among the five characteristic MRI lesions. Ten patients showed gadolinium-enhancing lesions, which were characterized by multiple patchy enhancing patterns with blurred margins. Conclusions: In central nervous system AQP4 autoimmunity, brain MRI abnormalities were more common than is generally appreciated and were characterized by their unique localization and configuration. </P>
-
Acute Oculogyric Crisis in a Patient Taking Clebopride
Kim, Woojun,Lee, Kwang-Soo,Kim, Yeong-In,Kim, Joong-Seok The Japanese Society of Internal Medicine 2008 Internal medicine Vol.47 No.6
<P>We present a 21-year-old woman with an oculogyric crisis following the administration of clebopride. Based on the temporal relationship of the administration of clebopride to the occurrence of the event and the absence of other possible etiologies, clebopride is implicated as the cause of this acute oculogyric crisis, despite the fact that a cause-and-effect relationship cannot be confirmed.</P>
-
Huh, So-Young,Min, Ju-Hong,Kim, Woojun,Kim, Su-Hyun,Kim, Ho Jin,Kim, Byung-Jo,Kim, Byoung Joon,Lee, Kwang Ho SAGE Publications 2014 Multiple sclerosis journal: clinical and laborator Vol.20 No.6
<P><B>Background:</B></P><P>Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and NMO spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, and even present with symptomatic brain involvement.</P><P><B>Objectives:</B></P><P>We investigated whether brain MRI at onset can be helpful for the differentiation of MS and NMOSD.</P><P><B>Methods:</B></P><P>We retrospectively analyzed initial brain MRIs, performed within three months of onset, in patients with MS (<I>n</I> = 51) and anti-aquaporin4-antibody-positive patients with NMOSD (<I>n</I> = 67).</P><P><B>Results:</B></P><P>NMOSD patients met the Paty (37%) and Barkhof (13%) criteria, and the criteria of the European Magnetic Imaging in MS (MAGNIMS) study group (9%), for MS. Ovoid lesions perpendicular to the lateral ventricle, isolated juxtacortical lesions in U-fibers and isolated ovoid/round cortical lesions were found only in MS patients, whereas longitudinal corticospinal tract lesions, extensive hemispheric lesions, periependymal lesions surrounding the lateral ventricle and cervicomedullary lesions were found only in NMOSD patients.</P><P><B>Conclusions:</B></P><P>Our study suggests that it is difficult to differentiate MS from NMOSD by the fulfillment of the MRI criteria for MS on brain MRI at onset; however, the characteristic morphology of brain lesions is highly useful for the early differentiation of the two disorders.</P>
-
Kim, Jeong Myeong,Lee, Hyo Jung,Kim, Sun Young,Song, Jae Jun,Park, Woojun,Jeon, Che Ok American Society for Microbiology 2010 Applied and environmental microbiology Vol.76 No.12
<B>ABSTRACT</B><P>To investigate the fine-scale diversity of the polyphosphate-accumulating organisms (PAO) “<I>Candidatus</I> Accumulibacter phosphatis” (henceforth referred to as “<I>Ca.</I> Accumulibacter”), two laboratory-scale sequencing batch reactors (SBRs) for enhanced biological phosphorus removal (EBPR) were operated with sodium acetate as the sole carbon source. During SBR operations, activated sludge always contained morphologically different “<I>Ca</I>. Accumulibacter” strains showing typical EBPR performances, as confirmed by the combined technique of fluorescence <I>in situ</I> hybridization (FISH) and microautoradiography (MAR). Fragments of “<I>Ca.</I> Accumulibacter” 16S rRNA genes were retrieved from the sludge. Phylogenetic analyses together with sequences from the GenBank database showed that “<I>Ca.</I> Accumulibacter” 16S rRNA genes of the EBPR sludge were clearly differentiated into four “<I>Ca.</I> Accumulibacter” clades, Acc-SG1, Acc-SG2, Acc-SG3, and Acc-SG4. The specific FISH probes Acc444, Acc184, Acc72, and Acc119 targeting these clades and some helpers and competitors were designed by using the ARB program. Microbial characterization by FISH analysis using specific FISH probes also clearly indicated the presence of different “<I>Ca.</I> Accumulibacter” cell morphotypes. Especially, members of Acc-SG3, targeted by probe Acc72, were coccobacillus-shaped cells with a size of approximately 2 to 3 μm, while members of Acc-SG1, Acc-SG2, and Acc-SG4, targeted by Acc444, Acc184, and Acc119, respectively, were coccus-shaped cells approximately 1 μm in size. Subsequently, cells targeted by each FISH probe were sorted by use of a flow cytometer, and their polyphosphate kinase 1 (<I>ppk1</I>) gene homologs were amplified by using a <I>ppk1</I>-specific PCR primer set for “<I>Ca.</I> Accumulibacter.” The phylogenetic tree based on sequences of the <I>ppk1</I> gene homologs was basically congruent with that of the 16S rRNA genes, but members of Acc-SG3 with a distinct morphology comprised two different <I>ppk1</I> genes. These results suggest that “<I>Ca.</I> Accumulibacter” strains may be diverse physiologically and ecologically and represent distinct populations with genetically determined adaptations in EBPR systems.</P>
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
