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Development of a surgical training model for bilateral axillo-breast approach robotic thyroidectomy
Yu, Hyeong Won,Yi, Jin Wook,Seong, Chan Yong,Kim, Jong-kyu,Bae, In Eui,Kwon, Hyungju,Chai, Young Jun,Kim, Su-jin,Choi, June Young,Lee, Kyu Eun Springer-Verlag 2018 Surgical endoscopy Vol.32 No.3
<P>Conclusions The BABA training model is an excellent educational tool for surgical residents and surgical fellows to learn and practice BABA RT. Assessment by BABA score yielded objective results comparable to those of traditional scoring methodologies.</P>
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Bae, Young-Han,Yu, Min-Ji,Vu, Minh Canh,Choi, Won Kook,Kim, Sung-Ryong Elsevier 2018 Composites science and technology Vol.155 No.-
<P><B>Abstract</B></P> <P>We present a simple method to improve the thermal and electrical conductivity of epoxy composites via sintering of formic acid-treated Cu nanoparticles (NPs) in the presence of polymethylmethacrylate (PMMA) beads. The surface-treated Cu NPs, epoxy, and PMMA beads were mixed and then sintered under 20 MPa of pressure at 200 °C. The morphology of the Cu NPs and the thermal conductivity, volume resistivity, and thermal stability of the epoxy composites were investigated. The significant improvement of the thermal and electrical conductivity of epoxy composites was attributed to segregation of the Cu NPs between PMMA beads and sintering of neighboring Cu NPs. At 30 wt% of Cu NPs, the thermal conductivity of the epoxy composites was 1.05 W/mK, and the volume resistivity was 5.9 × 10<SUP>10</SUP> Ω cm at a (bead)/(epoxy + bead) ratio of 0.6. The thermal stability of the composites increased with increasing cross-linked PMMA bead content. Low-temperature sintering of formic acid-treated Cu NPs in the presence of PMMA beads affords an innovative way to improve the thermal and electrical conductivity of the composites.</P>
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( Yu Jung Cho ),( June Sung Lee ),( Tae Jun Song ),( Won Ki Bae ),( Nam Hoon Kim ),( Kyung Ah Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: According to current guidelines, patients showing a partial virological response (PVR) at week 24 to nucleos(t)ide analogues (NA) with a low genetic barrier should change or add a more potent drug, and patients with PVR to NA with a higher genetic barrier can continue the same drug until week 48. However, there are few studies on a PVR at week 48 to drugs with a high genetic barrier such as entecavir (ETV). The aim is to assess long-term outcomes of chronic hepatitis B patients with a PVR to ETV at week 48. Methods: Chronic hepatitis B patients treated with entecavir 0.5mg for 1 year or longer at a single center were analyzed retrospectively. Virological response (VR) was defined as undetectable serum HBV DNA by real-time PCR (<300 copies/mL). PVR was defined as a decrease in HBV DNA of more than 1 log IU/mL but detectable serum HBV DNA by PCR. Results: Total 190 patients (116 NA-naive and 74 NA- experienced, male 67.9%. cirrhosis 35.8%, eAg-positive 42.1%) were analyzed in this study. VR was achieved in 80.2%, 88.9%, and 94.6% of NA-naive patients and 72.2%, 81.3%, 91.9% of NA-experienced patients at week 24, 48, and 96 respectively. Baseline serum HBV DNA and extent of HBV DNA decline were independent predictable factors for a PVR at week 48. Patient with a PVR achieved a VR at week 96 in 57.1% (60% in NA-naive patients, 54.5% in NA-experienced patients). Serum HBV DNA at week 48 was only predictable for achieving VR at week 96 (88.9% in patients with serum HBV DNA <1000 copies/mL, 0% in patients with serum HBV DNA ≥1000 copies/mL). Two out of 11 NA-experienced patients with a PVR at week 48 developed ETV-resistance, whereas none of 13 NA-naive patients with PVR developed antiviral resistance. Conclusion: Most of NA-naive patients with a PVR to ETV and serum HBV DNA < 1000 copies/mL at week 48 achieved a VR at week 96. However, patients with NA-experience or serum HBV DNA ≥1000 copies/mL at week 48 showed poor long-term outcome to ETV.
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( Yu Jung Jo ),( Kyung Ah Kim ),( June Sung Lee ),( Nam Hoon Kim ),( Won Ki Bae ),( Tae June Song ),( Jeong Wook Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2
Background/Aims: The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV. Methods: Chronic hepatitis B patients treated with ETV (0.5 mg/day) for at least 1 year were enrolled retrospectively. PVR was defined as a decrease in hepatitis B virus (HBV) DNA titer of more than 2 log10 IU/mL, yet with residual serum HBV DNA, as determined by real time-polymerase chain reaction, at week 48 of ETV therapy. Results: A total of 202 patients (127 NA-naive and 75 NA-experienced, male 70.8%, antigen positive 53.2%, baseline serum HBV DNA 6.2 ± 1.5 log10 IU/mL) were analyzed. Twenty-eight patients demonstrated a PVR. The PVR was associated with a high serum HBV DNA titer at baseline and at week 24. Virological response (< 60 IU/mL) was achieved in 46.2%, 61.5%, 77.6%, and 85% of patients with PVR at week 72, 96, 144, and 192, respectively. Resistance to antivirals developed in two NA-experienced patients. Failure of virological response (VR) in patients with PVR was associated with high levels of serum HBV DNA at week 48. Conclusions: Patients with PVR to ETV had favorable long-term virological outcomes. The low serum level of HBV DNA (< 200 IU/mL) at week 48 was associated with subsequent development of a VR in patients with PVR to ETV.
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Alpha-lipoic Acid Protects Neuronal Cells from Ethanol-induced Neurotoxicity
Yu Jeong Bae,Yoo Hun Noh,Do Hee Kim,Jiae Park,Ok Hyeon Kim,Seung-Ah Lee,Yoon Hee Chung,Seung Ho Han,Kyung Yong Kim,Won Bok Lee 중앙대학교 의과대학 의과학연구소 2014 中央醫大誌 Vol.39 No.2
Ethanol exposure has various toxic effects on the human nervous system results in various developmental and behavioral deficits. Present studies showed the protective effect of alpha-lipoic acid (LA), a potent natural anti-oxidant and anti-inflammatory molecule against various brain toxins. Since LA has attracted more attention for its anti-apoptotic properties, we investigated the neuroprotective efficacy of LA in EtOH-treated SH-SY5Y human neuroblastoma cells. The cell death was evaluated by MTT assay, morphological assessment. EtOH induced neuronal cell death in a time- and dose-dependent manner. The cell death examined was increased and the apoptotic morphological features, including retraction of neuritis, cell shrinkage, and membrane blebbing were induced by EtOH. However, in the cells treated with LA for 1h and exposed to EtOH the EtOH-induced neuronal cell death was significantly attenuated in a dose-dependent manner. The LA effectively inhibited SH-SY5Y cell death and apoptotic morphological changes in the cells induced by EtOH. Our results indicate that pretreatment with LA interrupts EtOH-induced apoptotic morphological change, and suggest that some of the protective effects of LA and other antioxidants likely involve classical antioxidant actions by EtOH-related brain damages and nerve injuries by oxidative stress which causes apoptosis.
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( Yu Mi Oh ),( Jung Won Jeon ),( Joung Il Lee ),( Hyun Phil Shin ),( Jae Myung Cha ),( Kwang Ro Joo ),( Jun Uk Lim ),( Il Hyun Baek ),( Myung Joon Chae ),( June Ho Bae ),( Chang Ju Kim ),( Il Gyu Ko ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Polydeoxyribonucleotide(PDRN) interacts with adenosine A2A-receptor,resulting in stimulating VEGF expression and facilitating wound healing. However,t he effects of PDRN on the gastric ulcer (GU) healing are still unknown. Methods: 60 Adult male Mongolian gerbils were used in this experiment.They were randomly divided into six groups (n = 10 each group):the sham-operation group,GU-induced group,GU-induced and 2,4,8,and16 mg/kg PDRN-treated group.GU was induced by injection of acetic acid into the subserosal surface of the stomach.After convalescent period of 2 days,gerbils in the PDRN-treated groups underwent intraperitoneal injection of 100 μl distilled water,which included PDRN of each concentration,once a day for 14 consecutive days.The sham-operation group and GU-induced group received an equal amount of distilled water without PDRN for the same duration.The gerbils were sacrifi ced after 16 days since the induction of GU.We investigated the effects of PDRN on the size of ulcer and VEGF expression in GU-induced Mongolian gerbils.In addition,we evaluated the effects of PDRN on apoptosis in GU using TUNEL-positive cells,caspase-3 positive cells,and Bax/Bcl-2 ratio in the gastric tissues. Results: PDRN administrations of 8 mg/kg and 16 mg/kg signifi cantly decreased the size of GU.Compared with GU-induced group,8 mg/kg and 16 mg/kg PDRN-treated group showed signifi cant overexpression of VEGF protein.In terms of anti-apoptosis,8 mg/kg and 16 mg/kg PDRN-treated group significantly decreased the number of TUNEL-positive cells in the stomach.In addition,8 mg/kg PDRN-treated group significantly suppressed caspase-3 expression.Induction of GU signifi cantly enhanced the ratio of Bax to Bcl-2.PDRN treatment suppressed Bax to Bcl-2 ratio.The suppressing effect of PDRN on Bax to Bcl-2 ratio appeared most potent at the 8 mg/kg dose. Conclusions: PDRN of 8 mg/kg overexpressed VEGF protein on acetic acid-inducedGU in Mongolian gerbils.This alteration is considered to promote GU healing.In addition, VEGF overexpressed by PDRN of 8 mg/kg inhibited apoptosis,and this effect is considered to prevent gastric ulcer or injury.
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Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans
( Won Il Heo ),( Kui Young Park ),( Mi-kyung Lee ),( Yu Jeong Bae ),( Nam Ju Moon ),( Seong Jun Seo ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.3
Background: Early-onset and severe atopic dermatitis (AD) in patients increase the probability of the development of allergic rhinitis or asthma. Treatment and prevention strategies in infants and young children with AD are targeted toward treating the symptoms, restoring skin barrier functions, and reducing the absorption of environmental allergens in an attempt to attenuate or block the onset of asthma and food allergy. Objective: Given that the initiating events in AD remain poorly understood, identifying those at risk and implementing strategies to prevent AD is necessary. Methods: Whole-exome sequencing (WES) was performed in a 43 control group and a disease group with 20 AD patients without atopic march (AM) and 20 with AM. Sanger sequencing was carried out to validate found variants in cohorts. Results: DOCK8, IL17RA, and KLK12 single-nucleotide polymorphisms were identified by WES as missense mutations: c.1289C>A, p.P97T (rs529208); c.1685C>A, p.P562G (rs12484684); and c.457+27>C, rs3745540, respectively. A case-control study show that total immunoglobulin E (IgE) level was significantly increased in the AA genotype of DOCK8 compared to the CA genotype in allergic patients. The rs12484684 of IL17RA increased risk of adult-onset AD (odds ratio: 1.63) compared to the control for (A) allele frequency. AD and AM Patients with the IL17RA CA genotype also had elevated IgE levels. rs3745540 of KLK12 was associated with AD in dominant model (odds ratio: 2.86). Conclusion: DOCK8 (rs529208), IL17RA (rs12484684), and KLK12 (rs3745540), were identified using a new WES filtering method. the result suggests that polymorphism of DOCK8 and IL17RA might be related to increase the total IgE level. (Ann Dermatol 32(3) 197∼205, 2020)
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Bae, Sang-Cheol,Jung, Won-Jin,Lee, Eun-Ju,Yu, Rina,Sung, Mi-Kyung A.R. Liss 2009 Journal of the American College of Nutrition Vol.28 No.1
<P>OBJECTIVE: Excess generation of reactive oxygen species in damaged joints accelerates inflammatory responses in RA (rheumatoid arthritis) patients. The complementary effects of dietary antioxidant supplementation on the blood level of inflammatory mediators and the severity of the disease in RA patients were evaluated. Study Design and Settings: The study was conducted as a randomized, placebo-controlled, double-blind, three-treatment cross-over design trial. The participants visited the hospital as outpatients. SUBJECTS: Twenty patients meeting the 1987 criteria for the classification of rheumatoid arthritis completed the study. INTERVENTIONS: The subjects were randomized in three groups to receive one of following supplementation; quercetin+vitamin C (166 mg+133 mg/capsule), alpha-lipoic acid (300 mg/capsule) or placebo for 4 weeks (3 capsules/day). Each treatment period consisted of 4 weeks with 2 weeks of wash-out period before the subject starts next supplementation. Outcome Parameters: Serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), interleukin -6(IL-6), and C-reactive protein (CRP) were measured. The severity of disease was evaluated using Korean Health Assessment Questionnaire(KHAQ) and Visual Analogue Scale(VAS). Nutrient intake was measured at baseline and at the end of each intervention period. RESULTS: The mean energy and nutrient intakes remained constant during study period. No significant differences were found in the serum concentrations of pro-inflammatory cytokines and CRP between treatments. The scores of disease severity measurements were not significantly different between treatments, although quercetin supplementation had a tendency to reduce VAS. CONCLUSIONS: Dietary supplementation of antioxidants at 900 mg/day for 4 weeks did not change the blood biomarkers of inflammation and disease severity of RA patients under conventional medical treatments. Further considerations for dose-response relationships, duration of supplementation, and susceptible biomarkers are required.</P>
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