권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

毛澤東의 軍事思想 小考

李基遠 동국대학교 행정대학원 1975 행정논집 Vol.6 No.-

ION-SELECTIVE ELECTRODES OF FERRITE MEMBRANES

원충택,박면용,오평제,이원,박기채 상명대학교 논문집 1993 상명대학교논문집 Vol.31 No.-

산화제2철 또는 산화제2철과 마그네슘, 구리, 니켈, 혹은 아연을 몰비가 0.6:2.4, 0.8:2.2, 1:2, 1.2:1.8 및 1.4:1.6 (M:Fe, M=Mg, Cu, Ni, Zn) 인 혼합물로 Ferrite막 전극을 만들어 이온 선택성 전극으로 사용될 가능성을 연구하였다. 이들 전극막 재료는 각각 900, 1,000, 1,100, 1,200, 1,300, 및 2,614-2,700℃에서 소결되었다. 소결 온도가 높을수록 이온 감도와 선택성이 컸다. 산화제2철만을 사용하였을 때 보다 산화제2철을 Mg,Cu,Ni 또는 Zn과 혼합하여 2,164-2,700℃ 에서 소결된 전극들이 이온 선택성이 우수하였다. 이들 전극의 전기저항치는 10^2 메그옴정도이다. 모든 전극의 정전앞감응을 pH3 및 10사이에서 관찰하였는데, 은(I), 인산염(III), 인산일수소염(II), 인산이수소염(I) 및 비소(V, III)에 민감하게 감응되었다. 이들전극은 물속에 계속해서 담궈두면 내구도가 6개월 정도였다.

알루미늄 연속주조 용탕의 탈 가스 일체화 장치 개발

이용중,김태원,김기대,류재엽,이형우 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

It is necessary for managing a perfect process for degasing aluminum molten metal according to the increase of a grade of aluminum and its alloy products. There are some methods that have been used to manage a degasing process in recent years, such as an injection method that uses aluminum molten metal powder and chemicals supplier and input method that supplies argon and nitrogen, or chlorine gas by using a gas blow-tube. However, these methods show some problems, and it shows that it is a difficult process to handle, pollution due to the producing a lot of toxic gases like chlorine and fluoride gas, irregular effects, and lowering work efficiency due to the excessive processing time. The problems that are the most fatal are the producing a lot of sludge due to the reaction of aluminum molten metal with chemicals, loss of metals, and decreasing the life of refractory materials. In order to solve these problems, this paper develops a technology that is related to aluminum continuous casting molten metal and monolithic degasing apparatus. A degasing apparatus developed in this study improved the existing methods and prevented environmental pollution with smokeless, odorless, and harmlessness by using a new method that applies argon and nitrogen gas in which the methods used in the West and Japan are eliminated. The developed method can significantly reduce product faults that are caused by the production of gas and oxidation because it uses a preprocessed molten metal with chemicals. In addition, the amount of the produced sludge can also be reduced by 60~80% maximum compared with the existing methods. Then, it makes it possible to minimize the loss of metals. Moreover, the molten metal processing and settling time is also shortened by comparing it with the existing methods that are applied by using chemicals. In addition, it does much to improve the workers' health, safety and environment because there is no pollution. The improvement of productivity and prevention effects of disaster from the results of the development can be summarized as follows. It will contribute to the process rationalization because it does not have any unnecessary processes that the molten metal will be moved to an agitator by using a ladle and returned to process for degasing like the existing process due to the monolithic configuration. There are no floating impurities due to the oxidation caused by the contact with the air as same as the existing process. In addition, it can protect the blending of precipitation impurities. Because it has a monolithic configuration, it can avoid the use of additional energy to compensate the temperature decreasing about 60? that is caused by the moving of molten metal. It is not necessary to invest an extra facilities in order to discharge the gas generated from a degasing process by using an agitator. The working environment can be improved by the hospitable air in the factory because the molten metal is almost not exposed in the interior of the area.

HPV에 감염된 자궁경부 상피세포의 Keratin 아형 변화에 관한 연구

기근홍,이영미,장원재,임용,임성철,김창원,전호종 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

The human papillomavirus (HPV) are wide spread in the world, causing proliferation of epidermal and mucosal surface. Certain papillomaviral types are oncogenic in vivo and in vitro. HPV DNA has been detected in most of cervical lesions such as condyloma acuminata, dysplasias, and invasive carcinomas. The materials for this study consisted of 5 dysplasias. 5 squamous cell carcinomas, and 5 exocervix for control, that resected for definite treatment of uterine disease at Chosen University Hospital from January, 1991 to December, 1993. All cases were performed of in situ hybridization for HPV DNA type 6/11, 16, and 18. And also immununohistochemical stain for panel of monoclonal cytokeratin (CK) antibodies were done. The result obtained is as fallows : 1. HPV DNA type 6/11 are detected in all dysplasias. HPV DNA type 16 and 18 are detected in squamous cell carcinomas. 2. Stratifed squamous epithelium of exocervix are positive staining for CK 1, CK 5/6, CK 8, CK 13, CK 14, and CK 19. HPV DNA type 6/11 infected cells are positive for CK 1, CK 13, CK 14, CK 17, CK 18, and CK 19. HPV DNA type 16/18 infected cells are positive for CK 1, CK 5/6, CK 10, CK 13, CK 14, CK 17, CK 18, and CK 19. In conclusion, HPV infection of uterine cervix is associated with change of normal cytokeratin expression pattern. Dysplastic cells are changed of CK 5/6, CK 8, CK 17 and CK18. Squamous cell carcinoma cells are changed of CK 8, CK 17, and CK 18.

일산화탄소 중독이 생쥐 신장의 Alkaline phosphatase 활성에 미치는 영향

이홍식,배기원 보건장학회 1975 보건장학회보연구논문집 Vol.4 No.-

급성 일산화탄소 중독 및 회복기의 흰쥐 전립선 Acid phosphatase 활성도의 변화

배기원,유진화,이흥식 대한해부학회 1976 Anatomy & Cell Biology Vol.9 No.2

염산 독세핀 외용제의 피부 전달 시스템을 위한 제제 설계 및 평가

이은미,김정수,경기열,이계원,지웅길 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

Doxepin hydrochloride(Dox) is a dibenzoxepin-derivative tricyclic antidepressant and used topically for the short-term relief of moderately severe pruritus associated with atopy dermatitis. Dox topical emulsion(or liposome) formulations were evaluated with respect to their rheological properities, permeation through excised skin of hairless mouse and in vitro/in vivo accumulation in the skin. The apparent viscosity was increased according to the concentration of glycerin and decreased with an increase in the concentration of phosphatidylcholine(PC). The permeation rate of formulation increased with a high concentration of PC and showed no relationship with the change of formulations. Amount of accumulated drug in the excised skin of hairless mouse was decreased with a high concentration of glycerin, but increased according to PC concentration.

하악 대구치에서 근관세척방법에 따른 잔사제거효과에 대한 평가

이소영,손원준,이우철,금기연,배광식,백승호 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.3

본 연구의 목적은 isthmus가 존재하는 하악 대구치의 근심 근관에서 근관세척방법에 따른 잔사제거효과를 평가하는 것이다. 45개의 하악 대구치의 근심근관을 #30 Profile .06까지 확대하였다. 각 근관을 3개의 군으로 나누고 conventional irrigation syringe와 초음파, RinsEndo를 사용하여 1분간 최종 세척하였다. 조직표본을 제작한 후, 광학현미경으로 치근단 1, 3, 5 mm 부위의 단면을 관찰하였다. 근관과 isthmus의 잔사 양으로 청결도를 계산하고 Mann-Whitney U test로 검정하였다. 1. 초음파 군과 syringe 군은 5 mm 부위의 isthmus를 제외한 나머지 부위에서 청결도의 유의한 차이가 없었다. 2. RinsEndo군은 syringe 군에 비해 1 mm, 3 mm 부위의 근관과, 모든 부위의 isthmus에서 유의하게 높은 청결도를 나타내었다(p<0.05). 3. 초음파 군과 RinsEndo 군은 3 mm 부위의 근관을 제외한 나머지 부위에서 청결도의 유의한 차이가 없었다. 임상적으로 RinsEndo를 이용한 근관세척방법의 부가적인 적용이 하악 대구치의 근심근관의 잔사제거에 효과가 있을 것으로 사료된다. The aim of this in vitro study was to evaluate the cleaning efficacy of various irrigation methods in the mandibular mesial roots. The forty five mesial root canals were shaped by Profile .06 instruments to apical size #30 and irrigated with 5 ml of 3.5% NaOCl. The teeth were divided into 3 groups and irrigated finally for 1 minute; Group 1: syringe irrigation, Group 2: ultrasonic irrigation, Group 3: RinsEndo irrigation. After histological processing, the cross sections of apical 1, 3, and 5 mm level were examined with an optical microscope. The cleanliness values of canals and isthmuses were calculated and analyzed by Mann-Whitney U test. 1. There were no significant differences in both canal and isthmus cleanliness between syringe irrigation and ultrasonic irrigation except 5 mm level of isthmus. 2. RinsEndo irrigation had significantly higher canal cleanliness values than syringe irrigation at 1 mm and 3 mm levels (p<0.05). Also, RinsEndo irrigation had significantly higher isthmus cleanliness VaIues than syringe irrigation at all levels evaluated (p<0.05). 3. There were no statistical differences in both canal and isthmus cleanliness between ultrasonic irrigation and RinsEndo irrigation except 3 mm level of canal. From this study, RinsEndo irrigation can be useful as an additional irrigation procedure.

노랑초파리 집단내 세대변화에 다른 Cytotype 및 P factor activity의 변화에 관한 연구

李尙源,成耆昌 성균관대학교 기초과학연구소 1997 論文集 Vol.48 No.-

Isofemale lines were estabilished from YJ island in August and September, 1990. After 15 generation, they tested for the G.D sterility by P-M system. And then, the results were compared G_1 and G_15 to cytotype conversion and P factor activity change. The results were as follows. It was analyzed to consist of M(0.3%), M' (56%), Q(42.6%) and no P strain in isofemale line(G_15). It was mainly consist of M' and Q strain like any other Korea region. And the cytotype are prevalent, though the P activity are very low in this population. During the period of 15 generation labortary culture, cytotype was transformed M cytotype (28.2% → 25.5%). And P factor activity decreased from 1.0% to 0.3%.