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Genome Architecture and Its Roles in Human Copy Number Variation
Lu Chen,Feng Zhang,Weichen Zhou,Ling Zhang 한국유전체학회 2014 Genomics & informatics Vol.12 No.4
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations(CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. Inthis review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats,including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNArecombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errorsand consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects thehigh-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genomearchitecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.
Genome Architecture and Its Roles in Human Copy Number Variation
Chen, Lu,Zhou, Weichen,Zhang, Ling,Zhang, Feng Korea Genome Organization 2014 Genomics & informatics Vol.12 No.4
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.
Biao Ma,Weichen Lu,He Wang,Liang Yu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.12
In order to realize the miniaturization and electrification of heavy vehicles, this paper innovatively puts forward a two-speed transmission device equiped with electrically controlled toothed band brakes. The dynamic models of the planetary gear and toothed band brake are derived, and the shift strategy is established to achieve the optimal dynamic performance. Moreover, the gearshift characteristics under different working parameters are studied to verify its feasibility. The results demonstrate that the toothed band brake has a short braking time and contributes to good shift performance, thus has potential for application. The effect of synchronous speed and actuator speed on shift performance is also analyzed. The increase of both speeds is beneficial to speed up the shift time, but lead to increased shift impact. The application of such a brake offers the possibility of full-electric and lightweight for electric vehicles.