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Jwariya Shamim(Jwariya Shamim ),Athar Parvez Ansari(Athar Parvez Ansari ),Pankaj Goswami(Pankaj Goswami ),Seema Akbar(Seema Akbar ),Huzaifa Ansari(Huzaifa Ansari ),Abdul Wadud(Abdul Wadud ),Pervaiz Ah 셀메드 세포교정의약학회 2023 셀메드 (CellMed) Vol.13 No.6
Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats. Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements. Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).
Regu Iqra Akram,Wadud Abdul,Rahman Khaleequr,Jabeen Uzma 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.1
Phyto-constituents and their efficacy vary with the age of the plant material and their affliction with environmental and storage conditions. Present study was conducted to evaluate the time dependent variation in physicochemical characters, glycyrrhi- zin content, microbial load and anti-inflammatory activity of Glycyrrhiza glabra L. root (GGR). Fresh GGR was dried and divided into three samples and stored as: sample A below 4 °C, sample B at room temperature and sample C at 40 ± 2 °C with relative humidity 75 ± 5% for six months. Afterwards, each sample was extracted in 50% alcohol and evaluated for phys- icochemical characters, glycyrrhizin content, microbial contamination and anti-inflammatory activity in histamine-induced inflammation in Wistar rats. Physicochemical characteristics exhibits less than 25% variation and qualitative analysis for plant metabolites exhibited similarity in all three samples. Glycyrrhizin was found more in sample C (5.07%) in comparison to sample B (4.52%) and A (4.72%) with variation less than 15%. As per the Ayurvedic Pharmacopeia of India these vari- ations in physicochemical parameters and glycyrrhizin content are insignificant. Sample A revealed total microbial count more than B and C. Accelerated stability data extrapolation of sample C suggests that shelf life of GGR is 2 years. Inflam- mation was significantly reduced by sample C followed by A and B in comparison to the control with residual paw volume of 0.9%, 3.22%, 20.4% and 29.7% respectively at 163 mg/kg BW dose. From the present study it can be concluded that up to two years age dependent variations in GGR is insignificant but its anti-inflammatory effect are glycyrrhizin dependent.