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- 저자 : Vincent H Wilson (검색결과 2 건)
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Vincent Onoriode Igben,Wilson Josiah Iju,Omogbiya Adrian Itivere,John Chukwuma Oyem,Peter Sunday Akpulu,Efe Endurance Ahama 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.2
Background: Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported amongst DM users. Earlier studies suggest that DM induces neurotoxicity and affect brain physiology. However, the exact neurological effects of DM extract in the medial prefrontal cortex (mPFC) and hippocampal morphology have not been elucidated. In this study, we evaluated the hypothesis that oral exposure to DM extract exerts a neurotoxic effect by increasing oxidative stress in the mPFC and the hippocampus and induces behavioral deficits in mice. Results: DM methanolic extract exposure significantly increased MDA and NO levels and reduced SOD, GSH, GPx and CAT activities in mice brains. In addition, our results showed that DM exposure produced cognitive deficits, anxiety, and depressive-like behaviour in mice following oral exposure for 28 days. Moreover, the mPFC and hippocampus showed neurodegenerative features, loss of dendritic and axonal arborization, a dose-dependent decrease in neuronal cell bodies’ length, width, area, and perimeter, and a dose-dependent increase in the distance between neuronal cell bodies. Conclusions: Oral exposure to DM in mice induces behavioural deficits, mPFC and hippocampal neuronal degenerations via redox imbalance in the brain of mice. These observations confirm the neurotoxicity of DM extracts and raises concerns on the safety and potential adverse effects of DM in humans.
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V. Vijayakumar,Pradeep Johnson,Ruban Whenish,A. John Rajan,Vincent H Wilson 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.4
The characteristics of Al 6061/SiCp Metal Matrix Composite (MMC) have been established for checking the suitability oflightweight spur gear using Powder Metallurgy (P/M) technique. Aluminium powder reinforced with SiCp particle withvarious weight.% (0, 5, 10 & 15) and particle sizes (35 μm and 65 μm). The smaller sized spur gears of 4 mm module, 48 mmpitch circle diameter and 22 mm face width were chosen. The complex gear profiled compaction die assembly was manufacturedfor making net shaped gear without any machining operation. The H frame hydraulic press was used to compact gear sampleswith compaction pressures of 132 MPa and 165 MPa. Then gear samples were sintered using muffle furnace at 570 ºC. Theprepared gear samples were used for density measurement, bending strength test, hardness measurement and microstructureanalysis. The research work leads to the observation of Al 6061 with 10 wt.% & 35 μm size of (SiCp) P/M gear exhibiting agreater enhancement of mechanical properties than the unreinforced Al alloy. Thus the effect of adding ceramic particles SiCpwith Al 6061 enhanced the mechanical properties and enabling Al 6061/SiCp composite spur gear suitable for lightweightapplications.
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