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        Effects of yoga breathing practice on heart rate variability in healthy adolescents: a randomized controlled trial

        Maheshkumar Kuppusamy,Dilara Kamaldeen,Ravishankar Pitani,Julius Amaldas,Padmavathi Ramasamy,Poonguzhali Shanmugam,Venugopal Vijayakumar 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.1

        Background: This study was conducted among healthy adolescents to assess the effects of a yoga breathing practice (Bhramari pranayama, Bhr.P) towards cardiac autonomic function using heart rate variability (HRV) parameters. Methods: Of the 730 eligible subjects screened, 520 healthy adolescents who met the inclusion and exclusion criteria were randomly assigned to either yoga breathing group (n = 260) or control group (n = 260). The yoga breathing group practiced Bhr.P. five days a week for a duration of six months while the control group continued with their daily routine without any intervention. Outcome measures were time and frequency domain of HRV in both groups which were assessed before and after the intervention using Lead II ECG. Linear models were used in the analysis of short term HRV. Results: After 6 months of yoga breathing, the time domain parameters of short term HRV showed significant (P < 0.05) improvement towards the parasympathetic domain. Frequency domain parameters also showed the same direction of changes. In contrast, control group subjects showed a trend towards a sympathetic domain. Conclusion: The present study showed a positive shift in cardiac autonomic modulation towards parasympathetic predominance after 6 months of yoga breathing practice among apparently healthy adolescents.

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        Synthesis and Characterization of Silver Nanoparticles from Marine Streptomyces parvisporogenes KL3 for Effective Antibacterial and Larvicidal Applications

        Thirumurugan Durairaj,Dhamodharan Duraisami,Thanigaivel Sundaram,Vadivalagan Chithravel,Vijayakumar Ramasamy,변헌수 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.4

        Recent studies have emphasized the application of nanoscience and nanotechnology to disease prevention, diagnosis, and treatment. This study examined the use of marine actinobacteria in the synthesis of silver nanoparticles (AgNPs). UV–Vis spectrophotometry, Fourier infrared spectroscopy, X-ray diff raction, scanning electron microscopy, and energy dispersive X-ray spectroscopy were used to characterize the primary structure, crystalline nature, functional groups, shape, and elemental signal of the synthesized AgNPs. The mean particle diameter of the AgNPs was measured, and the size was found to be between 23 and 27 nm. The antibacterial activity of the AgNPs was evaluated; it showed enhanced inhibitory activity against Escherichia coli , Bacillus subtilis , and Klebsiella pneumoniae . At an AgNP concentration of 40 g/mL, the test pathogen growth was completely inhibited. The larvicidal property of the synthesized AgNPs showed enhanced activity against An. stephensi (LC5017.511 and LC9050.572), A. aegypti (LC50 22.481 and LC90 61.920), and Cx. quinquefasciatus (LC50 29.548 and LC90 73.123). By analyzing the phenotypic data, the 16S rRNA gene sequence, and the phylogenetic data, the probable isolate was also determined to be Streptomyces parvisporogenes KL3. The study results prove that biosynthesized AgNPs can be used as eff ective antibacterial and larvicidal agents in drug formulation.

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