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Vera-Cabrera, Lucio,Gonzalez, Eva,Rendon, Adrian,Ocampo-Candiani, Jorge,Welsh, Oliverio,Velazquez-Moreno, Victor M.,Hak Choi, Sung,Molina-Torres, Carmen American Society for Microbiology 2006 Antimicrobial agents and chemotherapy Vol.50 No.9
<B>ABSTRACT</B><P>The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of <I>Nocardia brasiliensis</I> and <I>Mycobacterium tuberculosis</I> were determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of <I>M. tuberculosis</I>. The <I>N. brasiliensis</I> isolates showed an MIC90 of 1 μg/ml and an MIC50 of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for <I>M. tuberculosis</I> but fivefold-higher MICs for <I>N. brasiliensis</I>.</P>
In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867
Vera-Cabrera, Lucio,Castro-Garza, Jorge,Rendon, Adrian,Ocampo-Candiani, Jorge,Welsh, Oliverio,Choi, Sung Hak,Blackwood, Kym,Molina-Torres, Carmen American Society for Microbiology 2005 Antimicrobial agents and chemotherapy Vol.49 No.10
<B>ABSTRACT</B><P>The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of <I>Mycobacterium tuberculosis</I>. DA-7867 was the most active drug with an MIC90 of 0.125 μg/ml, compared to the MIC90s of 4 μg/ml of garenoxacin and 2 μg/ml of linezolid.</P>