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COMPUTATION OF SOMBOR INDICES OF OTIS(BISWAPPED) NETWORKS
B. Basavanagoud,Goutam Veerapur 충청수학회 2022 충청수학회지 Vol.35 No.3
In this paper, we derive analytical closed results for the first (a, b)-K A index, the Sombor index, the modified Sombor index, the first reduced (a, b)-K A index, the reduced Sombor index, the reduced modified Sombor index, the second reduced (a, b)-K A index and the mean Sombor index mSOα for the OTIS biswapped networks by considering basis graphs as path, wheel graph, com- plete bipartite graph and r − regular graphs. Network theory plays a significant role in electronic and electrical engineering, such as signal processing, networking, communication theory, and so on. A topological index (TI) is a real number associated with graph net- works that correlates chemical networks with a variety of physical and chemical properties as well as chemical reactivity. The Opti- cal Transpose Interconnection System (OTIS) network has recently received increased interest due to its potential uses in parallel and distributed systems.
Shalin Thakker,S M Biradar,PV Habbu,KM Mahadevan,BS Thippeswamy,VP Veerapur 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
Thakker, Shalin,Biradar, S.M.,Habbu, P.V.,Mahadevan, K.M.,Thippeswamy, B.S.,Veerapur, V.P. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
PV Habbu,KM Mahadevan,VH Kulkarni,Marietta P,Pratap V,BS Thippeswamy,VP Veerapur 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.2
Effect of ethanol (ASE) and water (ASW) extracts of Argyreia speciosa on blood glucose and lipid profile was investigated in normoglycemic and Streptozotocin (STZ)-induced diabetic animals. In oral glucose and sucrose tolerance test, treatment with ASE and ASW (100 and 200 mg/kg) and Glidenclamide (10 mg/kg) significantly improved the glucose and sucrose tolerance in normal animals. In addition, respective treatment for fifteen-day resulted in significant percentage reduction in serum glucose (SG) ie., 30.39% (lower dose of ASE) and 33.21% (higher dose of ASW). In standardized STZ (50 mg/kg, iv)-induced diabetic rats, a single dose of ASE and ASW treatment exhibited reduction in SG levels at different time intervals compared to basal levels. Administration of both the doses of ASE and ASW for fifteen-day days exhibited greater percentage reduction in glycemia (24.6%, 24.7%, 23.9% and 21.9% respectively) and also ameliorated restored to near normal value of all tested lipid parameters. Further, treatment also exhibited significantly improved glucose tolerance over the period of 120 min compared to diabetic control group. Eventhough treatment failed to increase serum insulin levels significantly but peripheral utilization of insulin was increased as evident by insulin tolerance test. Taken together, present study supports the traditional usage of title plant in the treatment of diabetes mellitus.
Adhikari Ashish,Basnet Santosh,Vijayakumar Sacchidanana,Suhas Doddamavattur Shivalingaiah,Puneeth Tumbadi Adinarayanashetty,Thippeswamy Boreddy Shivanandappa,Chandramohan Vivek,Veerapur Veeresh Prabha 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3
To expound the protective outcome of standardised hydroalcoholic extract of Blumea lacera (EEBL) in acetic acid-induced ulcerative colitis (UC). Further, in silico computational experiments were performed to identify the inhibitory activity of bioactive constituents of EEBL against inflammatory targets. Rats were pre-treated with EEBL (100 and 200 mg/kg) for 7 days and on eighth day, UC was induced by intrarectal instillation of 2 ml of 4% v/v acetic acid and treatment continues till 11th day. Colonic injury was examined by clinical activity score and mucosal inflammation was assessed by colon wet weight, macroscopic scoring and histopathological examination. In addition, colonic contractility studies and biochemical analysis were carried out. Further, bioactive compounds from title plant were subjected to drug likeness prediction and molecular docking studies against myeloid differentiation factor-2 (MD-2), nuclear factor-kappa B (NF-κB), tumor necrosis factor alpha (TNF-alpha) and soluble epoxide hydrolase (sEH). Pre-treatment with both the doses of EEBL significantly ameliorated the acetic acid-induced colonic injury and these results were parallels with biochemical and histopathology examinations. Out of fifteen selected bioactive compounds, 5-hydroxy-3methyl-3,6,7,4-tetramethoxy flavones, lachnophyllic acid and d-fenchone exhibited better drug likeness property with higher docking score. The observed protective outcome might be recognized due to the synergistic effect of identified bioactive compounds by inhibition of key targets of inflammation.