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- 저자 : Tim Clarke (검색결과 3 건)
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A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire Hall,Louise Clarke,Atanu Pal,Pamela Buchwald,Tim Eglinton,Chris Wakeman,Frank Frizelle 대한대장항문학회 2019 Annals of Coloproctolgy Vol.35 No.6
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
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Experimental Study of Capture Effect for Medium Access Control with ALOHA
Selahattin Kosunalp,David Grace,Tim Clarke 한국전자통신연구원 2015 ETRI Journal Vol.37 No.2
In this paper, we investigate the capture effect through experiments conducted with Iris nodes equipped with AT86RF230 radio transceivers. It is shown that the first arriving packet in a collision can capture the radio channel for equal power transmissions and may be decoded depending on the amount of overlap. A new 3-packet-capture scenario is introduced and implemented. To be able to understand the impact of capture on the throughput performance of wireless sensor networks, we present an analysis of the capture coefficient using our practical results. For real-world implementations, the throughput of pure ALOHA considering a finite number of users is presented in analytical form. The capture coefficient is then applied to pure ALOHA as a case study. Using analytical and practical implementations of the capture effect on ALOHA, a very good match in channel throughput performance enhancement is demonstrated over the non-capture effect case. TinyOS-2.x is used to program the nodes and to observe data exchange on a computer through a base station.
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Practical Implementation and Stability Analysis of ALOHA-Q for Wireless Sensor Networks
Selahattin Kosunalp,Paul Daniel Mitchell,David Grace,Tim Clarke 한국전자통신연구원 2016 ETRI Journal Vol.38 No.5
This paper presents the description, practical implementation, and stability analysis of a recently proposed, energy-efficient, medium access control protocol for wireless sensor networks, ALOHA-Q, which employs a reinforcement-learning framework as an intelligent transmission strategy. The channel performance is evaluated through a simulation and experiments conducted using a real-world test-bed. The stability of the system against possible changes in the environment and changing channel conditions is studied with a discussion on the resilience level of the system. A Markov model is derived to represent the system behavior and estimate the time in which the system loses its operation. A novel scheme is also proposed to protect the lifetime of the system when the environment and channel conditions do not sufficiently maintain the system operation.
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