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Ma, R. C. W.,Hu, C.,Tam, C. H.,Zhang, R.,Kwan, P.,Leung, T. F.,Thomas, G. N.,Go, M. J.,Hara, K.,Sim, X.,Ho, J. S. K.,Wang, C.,Li, H.,Lu, L.,Wang, Y.,Li, J. W.,Wang, Y.,Lam, V. K. L.,Wang, J.,Yu, W.,Ki Springer-Verlag 2013 Diabetologia Vol.56 No.6
<P><B>Aims/hypothesis</B></P><P>Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians.</P><P><B>Methods</B></P><P>We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations.</P><P><B>Results</B></P><P>We identified <I>CDKN2A/B</I> and four novel type 2 diabetes association signals with <I>p</I> < 1 × 10<SUP>−5</SUP> from the meta-analysis. Thirteen variants within these four loci were followed up in two independent Chinese cohorts, and rs10229583 at 7q32 was found to be associated with type 2 diabetes in a combined analysis of 11,067 cases and 7,929 controls (<I>p</I><SUB>meta</SUB> = 2.6 × 10<SUP>−8</SUP>; OR [95% CI] 1.18 [1.11, 1.25]). In silico replication revealed consistent associations across multiethnic groups, including five East Asian populations (<I>p</I><SUB>meta</SUB> = 2.3 × 10<SUP>−10</SUP>) and a population of European descent (<I>p</I> = 8.6 × 10<SUP>−3</SUP>). The rs10229583 risk variant was associated with elevated fasting plasma glucose, impaired beta cell function in controls, and an earlier age at diagnosis for the cases. The novel variant lies within an islet-selective cluster of open regulatory elements. There was significant heterogeneity of effect between Han Chinese and individuals of European descent, Malaysians and Indians.</P><P><B>Conclusions/interpretation</B></P><P>Our study identifies rs10229583 near <I>PAX4</I> as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the pathogenesis of type 2 diabetes.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00125-013-2874-4) contains peer-reviewed but unedited supplementary material, which is available to authorised users.</P>
Thomas Martin,Yi Wang,Shams Rashid,Xingfeng Shao,Steen Moeller,Peng Hu,Kyunghyun Sung,Danny J.J. Wang 대한자기공명의과학회 2017 Investigative Magnetic Resonance Imaging Vol.21 No.4
Purpose: To develop a novel combination of controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) with integrated SSFP (CAIPI-iSSFP) for accelerated SSFP imaging without banding artifacts at 3T. Materials and Methods: CAIPI-iSSFP was developed by adding a dephasing gradient to the balanced SSFP (bSSFP) pulse sequence with a gradient area that results in 2π dephasing across a single pixel. Extended phase graph (EPG) simulations were performed to show the signal behaviors of iSSFP, bSSFP, and RF-spoiled gradient echo (SPGR) sequences. In vivo experiments were performed for brain and abdominal imaging at 3T with simultaneous multi-slice (SMS) acceleration factors of 2, 3 and 4 with CAIPI-iSSFP and CAIPI-bSSFP. The image quality was evaluated by measuring the relative contrast-to-noise ratio (CNR) and by qualitatively assessing banding artifact removal in the brain. Results: Banding artifacts were removed using CAIPI-iSSFP compared to CAIPI-bSSFP up to an SMS factor of 4 and 3 on brain and liver imaging, respectively. The relative CNRs between gray and white matter were on average 18% lower in CAIPI-iSSFP compared to that of CAIPI-bSSFP. Conclusion: This study demonstrated that CAIPI-iSSFP provides up to a factor of four acceleration, while minimizing the banding artifacts with up to a 20% decrease in the relative CNR.
Duplex-Specific Nuclease-Amplified Detection of MicroRNA Using Compact Quantum Dot-DNA Conjugates
Wang, Ye,Howes, Philip D.,Kim, Eunjung,Spicer, Christopher D.,Thomas, Michael R.,Lin, Yiyang,Crowder, Spencer W.,Pence, Isaac J.,Stevens, Molly M. American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.34
<P>Advances in nanotechnology have provided new opportunities for the design of next-generation nucleic acid biosensors and diagnostics. Indeed, combining advances in functional nanoparticles, DNA nanotechnology, and nuclease-enzyme-based amplification can give rise to new assays with advantageous properties. In this work, we developed a microRNA (miRNA) assay using bright fluorescent quantum dots (QDs), simple DNA probes, and the enzyme duplex-specific nuclease. We employed an isothermal target-recycling mechanism, where a single miRNA target triggers the cleavage of many DNA signal probes. The incorporation of DNA-functionalized QDs enabled a quantitative fluorescent readout, mediated by Förster resonance energy transfer (FRET)-based interaction with the DNA signal probes. Our approach splits the reaction in two, performing the enzyme-mediated amplification and QD-based detection steps separately such that each reaction could be optimized for performance of the active components. Target recycling gave ca. 3 orders of magnitude amplification, yielding highly sensitive detection with a limit of 42 fM (or 1.2 amol) of miR-148, with excellent selectivity versus mismatched sequences and other miRNAs. Furthermore, we used an alternative target (miR-21) and FRET pair for direct and absolute quantification of miR-21 in RNA extracts from human cancer and normal cell lines.</P> [FIG OMISSION]</BR>
Thomas J. Wang,Marvin Ryou 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.2
Background/Aims: Shear wave elastography (SWE) is used for liver fibrosis staging based on stiffness measurements. It can be performed using endoscopic ultrasound (EUS) or a transabdominal approach. Transabdominal accuracy can be limited in patients with obesity because of the thick abdomen. Theoretically, EUS-SWE overcomes this limitation by internally assessing the liver. We aimed to define the optimal technique for EUS-SWE for future research and clinical use and compare its accuracy with that of transabdominal SWE. Methods: Benchtop study: A standardized phantom model was used. The compared variables included the region of interest (ROI) size, depth, and orientation and transducer pressure. Porcine study: Phantom models with varying stiffness values were surgically implanted between the hepatic lobes. Results: For EUS-SWE, a larger ROI size of 1.5 cm and a smaller ROI depth of 1 cm demonstrated a significantly higher accuracy. For transabdominal SWE, the ROI size was nonadjustable, and the optimal ROI depth ranged from 2 to 4 cm. The transducer pressure and ROI orientation did not significantly affect the accuracy. There were no significant differences in the accuracy between transabdominal SWE and EUS-SWE in the animal model. The variability among the operators was more pronounced for the higher stiffness values. Small lesion measurements were accurate only when the ROI was entirely situated within the lesion. Conclusions: We defined the optimal viewing windows for EUS-SWE and transabdominal SWE. The accuracy was comparable in the non-obese porcine model. EUS-SWE may have a higher utility for evaluating small lesions than transabdominal SWE.
Smart Machining Process Using Machine Learning: A Review and Perspective on Machining Industry
김동현,Thomas J. Y. Kim,Xinlin Wang,김민철,전영준,오진우,민수홍,김형중,Binayak Bhandari,양인순,안성훈 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.4
The Fourth Industrial Revolution incorporates the digital revolution into the physical world, creating a new direction in a number of fields, including artificial intelligence, quantum computing, nanotechnology, biotechnology, robotics, 3D printing, autonomous vehicles, and the Internet of Things. The artificial intelligence field has encountered a turning point mainly due to advancements in machine learning, which allows machines to learn, improve, and perform a specific task through data without being explicitly programmed. Machine learning can be utilized with machining processes to improve product quality levels and productivity rates, to monitor the health of systems, and to optimize design and process parameters. This is known as smart machining, referring to a new machining paradigm in which machine tools are fully connected through a cyber-physical system. This paper reviews and summarizes machining processes using machine learning algorithms and suggests a perspective on the machining industry.
Ritacco, Christopher J.,Kamtekar, Satwik,Wang, Jimin,Steitz, Thomas A. Oxford University Press 2013 Nucleic acids research Vol.41 No.4
<P>The serine family of site-specific DNA recombination enzymes accomplishes strand cleavage, exchange and religation using a synaptic protein tetramer. A double-strand break intermediate in which each protein subunit is covalently linked to the target DNA substrate ensures that the recombination event will not damage the DNA. The previous structure of a tetrameric synaptic complex of γδ resolvase linked to two cleaved DNA strands had suggested a rotational mechanism of recombination in which one dimer rotates 180° about the flat exchange interface for strand exchange. Here, we report the crystal structure of a synaptic tetramer of an unliganded activated mutant (M114V) of the G-segment invertase (Gin) in which one dimer half is rotated by 26° or 154° relative to the other dimer when compared with the dimers in the synaptic complex of γδ resolvase. Modeling shows that this rotational orientation of Gin is not compatible with its being able to bind uncleaved DNA, implying that this structure represents an intermediate in the process of strand exchange. Thus, our structure provides direct evidence for the proposed rotational mechanism of site-specific recombination.</P>
TEMPORAL CHANGE OF MAGNETIC SHEAR FREE FROM THE 180° AMBIGUITY
MOON Y.-J.,WANG HAIMIN,SPIROCK THOMAS J.,PARK Y. D. The Korean Astronomical Society 2002 Journal of The Korean Astronomical Society Vol.35 No.3
In this paper we present a methodology to derive the temporal change of the magnetic shear angle from a series of vector magnetograms, with a high time cadence. This method looks for the minimum change of the shear angle between a pair of magnetograms, free from the $180^{\circ}$ ambiguity, and then accumulates this change over many successive pairs to derive the temporal change of magnetic shear. This methodology will work well if only the successive magnetograms occurred in an active region are well aligned and its helicity sign is reasonably determined. We have applied this methodology to a set of vector magnetograms of NOAA Active Region 9661 on October 19, 2001 by the new digital magnetograph at the Big Bear Solar Observatory (BBSO). For this work we considered well aligned magnetograms whose cross-correlation values are larger than 0.95. As a result, we have confirmed the recent report of Wang et al. that there was the abrupt shear change associated with the X1.6 flare. It is also demonstrated that the shear change map can be an useful tool to highlight the local areas that experienced the abrupt shear change. Finally, we suggest that this observation should be a direct support of the emergence of sheared magnetic fields.
Choi, Eun-Mi,Fix, Thomas,Kursumovic, Ahmed,Kinane, Christy J,Arena, Darí,o,Sahonta, Suman-Lata,Bi, Zhenxing,Xiong, Jie,Yan, Li,Lee, Jun-Sik,Wang, Haiyan,Langridge, Sean,Kim, Young-Min,Borisevich John WileySons, Ltd 2014 Advanced Functional Materials Vol.24 No.47
<P>Highly strained films of BiFe<SUB>0.5</SUB>Mn<SUB>0.5</SUB>O<SUB>3</SUB> (BFMO) grown at very low rates by pulsed laser deposition were demonstrated to exhibit both ferrimagnetism and ferroelectricity at room temperature and above. Magnetisation measurements demonstrated ferrimagnetism (<I>T<SUB>C</SUB></I> ∼ 600K), with a room temperature saturation moment (<I>M<SUB>S</SUB></I>) of up to 90 emu/cc (∼ 0.58 <I>μ<SUB>B</SUB></I>/f.u) on high quality (001) SrTiO<SUB>3</SUB>. X-ray magnetic circular dichroism showed that the ferrimagnetism arose from antiferromagnetically coupled Fe<SUP>3+</SUP> and Mn<SUP>3+</SUP>. While scanning transmission electron microscope studies showed there was no long range ordering of Fe and Mn, the magnetic properties were found to be strongly dependent on the strain state in the films. The magnetism is explained to arise from one of three possible mechanisms with Bi polarization playing a key role. A signature of room temperature ferroelectricity in the films was measured by piezoresponse force microscopy and was confirmed using angular dark field scanning transmission electron microscopy. The demonstration of strain induced, high temperature multiferroism is a promising development for future spintronic and memory applications at room temperature and above.</P>
The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers
Amos, Christopher I.,Dennis, Joe,Wang, Zhaoming,Byun, Jinyoung,Schumacher, Fredrick R.,Gayther, Simon A.,Casey, Graham,Hunter, David J.,Sellers, Thomas A.,Gruber, Stephen B.,Dunning, Alison M.,Michail American Association for Cancer Research 2017 Cancer epidemiology, biomarkers & prevention Vol.26 No.1
<P>Impact: Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. (C)2016 AACR.</P>