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( Tatsuya Hayashi ),( Satoshi Saitoh ),( Kei Fukuzawa ),( Yoshinori Tsuji ),( Junji Takahashi ),( Yusuke Kawamura ),( Norio Akuta ),( Masahiro Kobayashi ),( Kenji Ikeda ),( Takeshi Fujii ),( Tosiaki M 대한간학회 2017 Gut and Liver Vol.11 No.5
Background/Aims: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the he-patic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in patients with NAFLD. Methods: A total of 130 patients who were diagnosed with NAFLD and underwent Gd-EOB-DTPA-enhanced MRI were retrospectively included. Histological data were available for 118 patients. Hepatic volumetric parameters, including the left hepatic lobe to right hepatic lobe volume ratio (L/R ratio), were measured. The usefulness of the L/R ratio for diag-nosing fibrosis ≥F3-4 and F4 was assessed using the area under the receiver operating characteristic (AUROC) curve. Multiple regression analysis was performed to identify vari-ables (age, body mass index, serum fibrosis markers, and histological features) that were associated with the L/R ratio. Results: The L/R ratio demonstrated good performance in differentiating advanced fibrosis (AUROC, 0.80; 95% confi-dence interval, 0.72 to 0.88) from cirrhosis (AUROC, 0.87; 95% confidence interval, 0.75 to 0.99). Multiple regression analysis showed that only fibrosis was significantly associat-ed with the L/R ratio (coefficient, 0.121; p<0.0001). Conclu-sions: The L/R ratio, which is not influenced by pathologi-cal parameters other than fibrosis, is useful for diagnosing cirrhosis in patients with NAFLD. (Gut Liver 2017;11:674- 683)
HIROYUKI KUMANO,Tatsunori Asaoka,Tatsuya Hayashi,Peng Zhang 대한설비공학회 2015 International Journal of Air-Conditioning and Refr Vol.23 No.3
The specific heat of a tetra-n-butyl ammonium bromide (TBAB) aqueous solution, the latent heat of a TBAB hydrate, and the specific enthalpy of a TBAB hydrate slurry were measured to understand the thermal storage characteristics of TBAB hydrate slurry. A solution sample and the hydrate slurry were heated, the change in temperature was measured, and the specific heat of the TBAB aqueous solution and the specific enthalpy of the hydrate slurry were obtained from the change in temperature. Two types of TBAB hydrate form. Therefore, the hydrates were separated from the hydrate slurry formed from TBAB aqueous solution having several initial concentrations. The hydrate crystals were placed into solution, and the latent heats were obtained from the temperature change of the solution. The specific enthalpy of the hydrate slurry was estimated from the latent heats of the hydrate crystals and the specific heat of the solution under phase equilibrium conditions, and the measured and estimated values were compared.
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
Kim, Sun Kwang,Hayashi, Hideaki,Ishikawa, Tatsuya,Shibata, Keisuke,Shigetomi, Eiji,Shinozaki, Youichi,Inada, Hiroyuki,Roh, Seung Eon,Kim, Sang Jeong,Lee, Gihyun American Society for Clinical Investigation 2016 The Journal of clinical investigation Vol.126 No.5
<P>Long-term treatments to ameliorate peripheral neuropathic pain that includes mechanical allodynia are limited. While glial activation and altered nociceptive transmission within the spinal cord are associated with the pathogenesis of mechanical allodynia, changes in cortical circuits also accompany peripheral nerve injury and may represent additional therapeutic targets. Dendritic spine plasticity in the S1 cortex appears within days following nerve injury; however, the underlying cellular mechanisms of this plasticity and whether it has a causal relationship to allodynia remain unsolved. Furthermore, it is not known whether glial activation occurs within the S1 cortex following injury or whether it contributes to this S1 synaptic plasticity. Using in vivo 2-photon imaging with genetic and pharmacological manipulations of murine models, we have shown that sciatic nerve ligation induces a re-emergence of immature metabotropic glutamate receptor 5 (mGluR5) signaling in S1 astroglia, which elicits spontaneous somatic Ca2+ transients, synaptogenic thrombospondin 1 (TSP-1) release, and synapse formation. This S1 astrocyte reactivation was evident only during the first week after injury and correlated with the temporal changes in S1 extracellular glutamate levels and dendritic spine turnover. Blocking the astrocytic mGluR5-signaling pathway suppressed mechanical allodynia, while activating this pathway in the absence of any peripheral injury induced long-lasting (>1 month) allodynia. We conclude that reawakened astrocytes are a key trigger for S1 circuit rewiring and that this contributes to neuropathic mechanical allodynia.</P>
흉부(胸部) 경선질촬영(硬線質撮影)에 있어서 피폭선양(被曝線量)의 저감(低減)에 관(關)한 연구(硏究)
임태랑,석전유치,전전미향,앵정달야,김정웅,황종선,Hayashi, Taro,Ishida, Yuji,Maeda, Mika,Sakurai, Tatsuya,Kim, Chung-Woon,Hwang, Jong-Sun 대한방사선과학회 1991 방사선기술과학 Vol.14 No.2
Experiment was conducted on the image quality and exposure dose following replacement of $CaWO_4$ system screen BH-III and BX-III which have so far been used for high-voltage hard-radiation quality radiography, with rare earth system screen KO750, combined with high contrast film SRH, while additional filter was altered, Cu 0.8 mm+Al 1.4 mm(HVL : Al 8.8 mm), Cu 1.3 mm+Al 1.0 mm(HVL : Al 10.6 mm) and Cu 1.8 mm+Al 1.5 mm(HVL : Al 11.4 mm). AS a result, visual evaluation did not detect extreme changes in image quality under the respective condition(HVL : $Al\;8.8\;mm{\sim}Al\;11.4\;mm$). It was noted, however, that surface exposure dose declined with an increase in the thickness of the additional filter, as it was $18.9\;{\mu}Gy$ at HVL Al 8.8 mm, $17.5\;{\mu}Gy$ at Al 10.6 mm and $15.7\;{\mu}Gy$ at Al 11.4 mm. Considering the limited rating of X-ray equipment and wear of machinery, however, the range of $Cu\;1.3\;mm{\sim}1.8\;mm+Al\;1.0\;mm{\sim}1.5\;mm(1/16\;VL{\sim}1/32\;VL)$ seemed to be a limit.
Ohshima, Jun,Lee, Youngae,Sasai, Miwa,Saitoh, Tatsuya,Su Ma, Ji,Kamiyama, Naganori,Matsuura, Yoshiharu,Pann-Ghill, Suh,Hayashi, Mikako,Ebisu, Shigeyuki,Takeda, Kiyoshi,Akira, Shizuo,Yamamoto, Masahiro The American Association of Immunologists, Inc. 2014 JOURNAL OF IMMUNOLOGY Vol.192 No.7
<P>IFN-γ mediates cellular innate immunity against an intracellular parasite, <I>Toxoplasma gondii</I>, by inducing immunity-related GTPases such as p47 IFN-γ–regulated GTPases (IRGs) and p65 guanylate-binding proteins (GBPs), which also participate in antibacterial responses via autophagy. An essential autophagy protein, Atg5, was previously shown to play a critical role in anti–<I>T. gondii</I> cell-autonomous immunity. However, the involvement of other autophagy proteins remains unknown. In this study, we show that essential autophagy proteins differentially participate in anti–<I>T. gondii</I> cellular immunity by recruiting IFN-γ–inducible GTPases. IFN-γ–induced suppression of <I>T. gondii</I> proliferation and recruitment of an IRG Irgb6 and GBPs are profoundly impaired in Atg7- or Atg16L1-deficient cells. In contrast, cells lacking other essential autophagy proteins, Atg9a and Atg14, are capable of mediating the anti–<I>T. gondii</I> response and recruiting Irgb6 and GBPs to the parasites. Although IFN-γ also stimulates anti–<I>T. gondii</I> cellular immunity in humans, whether this response requires GBPs and human autophagy proteins remains to be seen. To analyze the role of human ATG16L1 and GBPs in IFN-γ–mediated anti–<I>T. gondii</I> responses, human cells lacking ATG16L1 or GBPs were generated by the Cas9/CRISPR genome-editing technique. Although both ATG16L1 and GBPs are dispensable for IFN-γ–induced inhibition of <I>T. gondii</I> proliferation in the human cells, human ATG16L1 is also required for the recruitment of GBPs. Taken together, human ATG16L1 and mouse autophagy components Atg7 and Atg16L1, but not Atg9a and Atg14, participate in the IFN-γ–induced recruitment of the immunity-related GTPases to the intracellular pathogen.</P>
Development of Knee Joint Robot for Students Becoming Therapist
Yoshifumi Morita,Yuki Kawai,Yusuke Hayashi,Tatsuya Hirano,Hiroyuki Ukai,Kouji Sanaka,Hironori Nakamuta,Keiko Takao 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
The authors are developing a knee joint robot as an educational tool for students becoming physical therapist (PT) or occupational therapist (OT). The robot can simulate some problems of a knee joint, such as range of motion trouble, contracture, rigidity, spasticity and so on. The robot has a knee joint mechanism to realize not only flexion/extension movement but also inner/outer rotation movement, which is based on the idea of rolling, sliding and coming off movement. In addition the robot has the wire drive system to control the knee joint passive movement. In this paper we design optimal arrangement of four pulleys in the wire drive system by introducing performance indices. In addition we design control algorithms to imitate two kinds of knee joint troubles and verify the effectiveness by fundamental experiments.