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RISS 인기검색어
- 검색키워드
- 저자 : Tapash R. Rautray (검색결과 3 건)
- 무료
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Strontium-substituted biphasic calcium phosphate scaffold for orthopedic applications
Mohapatra Bijayinee,Rautray Tapash R. 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.4
Strontium ion-substituted calcium phosphate-based ceramic scaff olds enhance osteogenesis. The objective of the present study was to optimize the strontium hydroxyapatite (Sr-HA) and beta tricalcium phosphate (β-TCP) ratio in the fabricated scaff olds to enhance their mechanical strength and bioactivity with controlled biodegradability. Porous polyurethane sponge scaff olds containing Sr-HA and β-TCP in varying concentration were developed by dipping 3D sponge pieces into a slurry containing 10% gelatin, proper concentration of biphasic calcium phosphate (BCP) and 3% poly vinyl alcohol. Four diff erent samples [Sr-BCP, Sr-BCP (20/80), Sr-BCP (30/70), Sr-BCP (40/60)] were prepared and were characterized for biodegradability, water uptake capability and cytotoxicity using various techniques. Pure, crystalline, cytocompatible Sr-BCP Scaff olds possessing both micropores and macropores with porosity greater than 80% and water uptake capability above 100% were obtained. Thus, the eff ective substitution of Sr-HA and β-TCP in varying proportion makes the composite scaff old a distinctive material of bone tissue engineering.
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Silver‑incorporated hydroxyapatite–albumin microspheres with bactericidal effects
Saswati Mishra,Tapash R. Rautray 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.2
Bacterial adhesion on HA-coated implant is a serious problem that often leads to bone infection such as osteomyelitis on implant sites. Gram-positive bacteria such as Staphylococcus aureus are responsible for such infection-forming biofilm on implant surfaces. Therefore, inclusion of antimicrobial agents especially inorganic ions such as silver has gained vogue due to their strong antibacterial effects. This study reports the fabrication of porous Ag–albumin–HA microspheres by waterin- oil emulsion technique. Varied proportions of porogen with HA ensured enhanced pores in the fabricated microsphere. Further, SEM analysis revealed the presence of microspheres in the range ~ 50–900 μm with interconnected pores ranging between ~ 10 and 50 μm. Antibacterial efficacy of the Ag–HA hybrid disrupting the biofilm was observed. The as-formed microspheres having interconnected pore channels are envisaged to show vascularization as well as fulfilling goals of ideal bone filler ensuring biocompatibility and reducing long-term cytotoxicity at implant site.
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The structural and bioactive behaviour of strontium‑doped titanium dioxide nanorods
Rinmayee Praharaj,Snigdha Mishra,Tapash R. Rautray 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.3
In the present work, various concentrations of strontium ions loaded titanium dioxide nanorods and common titanium dioxide nanorods (control) were synthesized by electrochemical anodization technique to get the implant with superior bioactivity. Cell viability and antibacterial efficacy studies were estimated using MTT assay and solid agar medium. The characterisation results confirmed that Sr2+ was successfully incorporated into TiO2 nanorods. Compared with common TiO2 nanorods (control), Sr2+ loaded TiO2 nanorods showed higher surface roughness, adhesion strength, and water wetting angle. MTT assay showed better cell response on Sr-TiO2 nanorod surface as compared to control and the antibacterial test showed that Sr2+ loaded TiO2 nanorods have superior antibacterial activity against pathogenic bacterial strain E. coli and S. aureus. Sr2+ incorporated TiO2 nanorod arrays can be used as a potential candidate for hard tissue implant applications.
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