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Matsumoto, Takahiro,Ohkubo, Kei,Honda, Kaoru,Yazawa, Akiko,Furutachi, Hideki,Fujinami, Shuhei,Fukuzumi, Shunichi,Suzuki, Masatatsu American Chemical Society 2009 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.131 No.26
<P>A (mu-eta(2):eta(2)-peroxo)dicopper(II) complex, [Cu(2)(H-L)(O(2))](2+) (1-O(2)), supported by the dinucleating ligand 1,3-bis[bis(6-methyl-2-pyridylmethyl)aminomethyl]benzene (H-L) is capable of initiating C-H bond activation of a variety of external aliphatic substrates (SH(n)): 10-methyl-9,10-dihydroacridine (AcrH(2)), 1,4-cyclohexadiene (1,4-CHD), 9,10-dihydroanthracene (9,10-DHA), fluorene, tetralin, toluene, and tetrahydrofuran (THF), which have C-H bond dissociation energies (BDEs) ranging from approximately 75 kcal mol(-1) for 1,4-CHD to approximately 92 kcal mol(-1) for THF. Oxidation of SH(n) afforded a variety of oxidation products, such as dehydrogenation products (SH((n-2))), hydroxylated and further-oxidized products (SH((n-1))OH and SH((n-2))=O), dimers formed by coupling between substrates (H((n-1))S-SH((n-1))) and between substrate and H-L (H-L-SH((n-1))). Kinetic studies of the oxidation of the substrates initiated by 1-O(2) in acetone at -70 degrees C revealed that there is a linear correlation between the logarithms of the rate constants for oxidation of the C-H bonds of the substrates and their BDEs, except for THF. The combination of this correlation and the relatively large deuterium kinetic isotope effects (KIEs), k(2)(H)/k(2)(D) (13 for 9,10-DHA, approximately > 29 for toluene, and approximately 34 for THF at -70 degrees C and approximately 9 for AcrH(2) at -94 degrees C) indicates that H-atom transfer (HAT) from SH(n) (SD(n)) is the rate-determining step. Kinetic studies of the oxidation of SH(n) by cumylperoxyl radical showed a correlation similar to that observed for 1-O(2), indicating that the reactivity of 1-O(2) is similar to that of cumylperoxyl radical. Thus, 1-O(2) is capable of initiating a wide range of oxidation reactions, including oxidation of aliphatic C-H bonds having BDEs from approximately 75 to approximately 92 kcal mol(-1), hydroxylation of the m-xylyl linker of H-L, and epoxidation of styrene (Matsumoto, T.; et al. J. Am. Chem. Soc. 2006, 128, 3874).</P>
Clinical Outcomes of Surgical Treatments for Traumatic Spinal Injuries due to Snowboarding
Takahiro Masuda,Kei Miyamoto,Kazuhiko Wakahara,Kazu Matsumoto,Akira Hioki,Tetsuya Shimokawa,Katsuji Shimizu,Shinji Ogura,Haruhiko Akiyama 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.1
Study Design: Retrospective study. Purpose: To assess treatment outcomes of snowboarding-related spinal and spinal cord injuries. Overview of Literature: Snowboarding-related spinal or spinal cord injury have a great impact on social and sporting activities. Methods: A retrospective review of 19 cases of surgically treated snowboard-related injury was done. Analyzed parameters included site of injury, type of fracture, peri- and postoperative complications, pre- and postoperative neurological status, activities of daily living, and participation in sports activities at the final follow-up. Results: The major site of injury was the thoracolumbar junction caused by fracture-dislocation (13/19 cases). The remaining 6 cases had cervical spine injuries. Over 60% of the patients had Frankel A and B paralysis. All patients were surgically treated by posterior fusion with instrumentation. Five underwent additional anterior fusion. Surgical outcome was restoration of ambulatory capacity in 12 patients (63.2%). Ultimately, 15 patients (78.9%) could return to work. Patients with complete paralysis upon admission showed reduced ambulatory capacity compared to those with incomplete paralysis. None of the patients again participated in any sports activities, including snowboarding. Conclusions: Snowboarding-related spinal or spinal cord injury has a great impact on social as well as sports activities. It is necessary to enhance promotion of injury prevention emphasizing the snowboarders’ responsibility code.
Matsumoto, Kazumasa,Hirayama, Takahiro,Kobayashi, Kentaro,Hirano, Syuhei,Nishi, Morihiro,Ishii, Daisuke,Tabata, Ken-ichi,Fujita, Tetsuo,Iwamura, Masatugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Objective: We evaluated the association of body mass index (BMI) with perioperative outcomes in patients who underwent laparoscopic or open radical nephroureterectomy. Materials and Methods: This retrospective single-center study included 113 patients who had been diagnosed with upper urinary tract cancer from January 1998 to June 2013 and were treated with laparoscopic nephroureterectomy (Lap group, n=60) or open nephroureterectomy (Open group, n=53). Laparoscopic nephroureterectomy was performed via a retroperitoneal approach following an open partial cystectomy. The two surgical groups were stratified into a normal-BMI group (<25) and a high-BMI group ($BMI{\geq}25$). The high-BMI group included 27 patients: 13 in the Lap group and 14 in the Open group. Results: Estimated blood loss (EBL) in the Lap group was much lower than that in the Open group irrespective of BMI (p<0.01). Operative time was significantly prolonged in normal-BMI patients in the Lap group compared to those in the Open group (p=0.03), but there was no difference in operative time between the Open and Lap groups among the high-BMI patients. Multivariate logistic regression analysis of the data for all the cohorts revealed that the open procedure was a significant risk factor for high EBL (p<0.0001, hazard ratio 8.02). Normal BMI was an independent predictor for low EBL (p=0.01, hazard ratio 0.25). There was no significant risk factor for operative time in multivariate analysis. There were no differences in blood transfusion rates or adverse event rates between the two surgical groups. Conclusions: Laparoscopic radical nephroureterectomy via a retroperitoneal approach can be safely performed with significantly reduced EBL even in obese patients with upper urinary tract cancer.
Matsumoto, Kazumasa,Ikeda, Masaomi,Hirayama, Takahiro,Nishi, Morihiro,Fujita, Tetsuo,Hattori, Manabu,Sato, Yuichi,Ohbu, Makoto,Iwam, Masatsugu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Background: The aim of this study was to evaluate 10 years of false positive urine cytology records, along with follow-up histologic and cytologic data, to determine the significance of suspicious urine cytology findings. Materials and Methods: We retrospectively reviewed records of urine samples harvested between January 2002 and December 2012 from voided and catheterized urine from the bladder. Among the 21,283 urine samples obtained during this period, we located 1,090 eligible false positive findings for patients being evaluated for the purpose of confirming urothelial carcinoma (UC). These findings were divided into three categories: atypical, indeterminate, and suspicious of malignancy. Results: Of the 1,090 samples classified as false positive, 444 (40.7%) were categorized as atypical, 367 (33.7%) as indeterminate, and 279 (25.6%) as suspicious of malignancy. Patients with concomitant UC accounted for 105 (23.6%) of the atypical samples, 147 (40.1%) of the indeterminate samples, and 139 (49.8%) of the suspicious of malignancy samples (p<0.0001). The rate of subsequent diagnosis of UC during a 1-year follow-up period after harvesting of a sample with false positive urine cytology initially diagnosed as benign was significantly higher in the suspicious of malignancy category than in the other categories (p<0.001). The total numbers of UCs were 150 (33.8%) for atypical samples, 213 (58.0%) for indeterminate samples, and 199 (71.3%) for samples categorized as suspicious of malignancy. Conclusions: Urine cytology remains the most specific adjunctive method for the surveillance of UC. We demonstrated the clinical value of dividing false positive urine cytology findings into three categories, and our results may help clinicians better manage patients with suspicious findings.
Matsumoto, Kazumasa,Mochizuki, Kohei,Hirayama, Takahiro,Ikeda, Masaomi,Nishi, Morihiro,Tabata, Ken-ichi,Okazaki, Miyoko,Fujita, Tetsuo,Taoka, Yoshinori,Iwamura, Masatsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
This study was conducted to evaluate the effectiveness of a combination of gemcitabine and nedaplatin therapy among patients with metastatic urothelial carcinoma previously treated with two lines of chemotherapy. Between February 2009 and August 2013, 30 patients were treated with gemcitabine and paclitaxel as a second-line chemotherapy. All had received a first-line chemotherapy consisting of methotrexate, vinblastine, doxorubicin and cisplatin. Ten patients who had measurable histologically proven advanced or metastatic urothelial carcinoma of the urinary bladder and upper urinary tract received gemcitabine $1,000mg/m^2$ on days 1, 8 and 15 and nedaplatin $70mg/m^2$ on day 2 as a third-line chemotherapy. Tumors were assessed by imaging every two cycles. The median number of treatment cycles was 3.5. One patient had partial response and three had stable disease. The disease-control rate was 40%, the median overall survival was 8.8 months and the median progression-free survival was 5.0 months. The median overall survival times for the first-line and second-line therapies were 29.1 and 13.9 months, respectively. Among disease-controlled patients (n=4), median overall survival was 14.2 months. Myelosuppression was the most common toxicity. There were no therapy-related deaths. Gemcitabine and nedaplatin chemotherapy is a favorable third-line chemotherapeutic option for patients with metastatic urothelial carcinoma. Given the safety and benefit profile seen in this study, further prospective trials are warranted given the implications of our results with regard to strategic chemotherapy for patients with advanced or metastatic urothelial carcinoma.
Matsumoto, Kazuhiro,Hagiwara, Masayuki,Hayakawa, Nozomi,Tanaka, Nobuyuki,Ito, Yujiro,Maeda, Takahiro,Ninomiya, Akiharu,Nagata, Hirohiko,Nakamura, So Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
The aim of this study was to evaluate the efficacy of third-line combined androgen blockade (CAB) therapy for castration-resistant prostate cancer that relapsed after primary and second-line CAB. We retrospectively reviewed the medical records of 52 patients who received first-, second-, and third-line CAB therapy (medical or surgical castration, plus steroidal antiandrogen of chlormadinone acetate, or nonsteroidal antiandrogen of flutamide or bicalutamide). For cumulative analysis, we searched the PubMed database and identified a total of 50 cases published in English. Including our cases, this provided a total of 102 cases for analysis. In our study cohort, 11 cases (21.2%) achieved more than 50% reduction of serum prostate-specific antigen (PSA) on initiation of third-line CAB. We found that third-line CAB with nonsteroidal antiandrogen after second-line CAB with steroidal antiandrogen exhibited favorable results, with a positive response in six of 13 patients (46.2%). Cumulative analysis findings were comparable. Regarding the timing of third-line CAB administration, 15 patients had started at a PSA equal to or less than 4.0 ng/ml, and eight of them (53.3%) showed a positive response to treatment, compared to only three of 37 patients (8.1%) whose PSA at the initiation of third-line therapy was higher than 4.0 ng/ml (p<0.001). We conclude that third-line CAB with nonsteroidal antiandrogen would be particularly useful for patients whose cancer progressed after second-line CAB with steroidal antiandrogen. The timing of treatment seems to be important because the higher the PSA at the start of third-line therapy, the lower the PSA response rate.
Experimental Evaluation of Optical ZCZ-CDMA System
Yu Suwaki,Takahiro Matsumoto,Shinya Matsufuji 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
The optical ZCZ code, which is a set of pairs of binary and bi-phase sequences with zero correlation zone, can provide optical code division multiple access (CDMA) communication system without co-channel interference. We proposed the compact construction of a code generator and a bank of matched filters for this code. This paper gives and evaluates an optical ZCZ-CDMA wireless communication system, consisting of a infrared light emitting diode(LED), an avalanche photo diode(APD) module and field programmable gate array(FPGA) boards corresponding to 400, 000 logic gates.