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Apoptotic effects of 1,5-bis-(5-nitro-2-furanyl)-1,4-pentadien-3- one on Drosophila SL2 cells
Yuan-Hang Ren,Hong Jin,Ke Tao,Tai-Ping Hou 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.2
n recent years, concerns over the potential impact of synthetic pesticides on the environment have promoted the research and development of environmentally friendly “green” pesticides. In the current study, we utilized a green biomimetic insecticide, 1,5-bis- (5-nitro-2-furanyl)-1,4-pentadien-3-one (compound C), to examine its cytotoxicity on an insect cell line, Drosophila melanogaster (SL2). Results from MTT assay showed cells treated with 100 μM of compound C for 48 h significantly inhibited the growth of SL2 cells by 87.71±0.96%. We subsequently attempted to illustrate the act on mechanism of compound C at the cellular level and found that it initiated apoptosis through a mitochondrial-dependent mechanism that increased the activity of caspase-3 and altered the cell cycle. These results suggest that the green biomimetic insecticide, compound C, is a novel and potent inducer of insect cell apoptosis.