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RISS 인기검색어
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- 저자 : Subhasmita Swain (검색결과 2 건)
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Subhasmita Swain,Rabindra Nath Padhy,Tapash Ranjan Rautray 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.5
For fabricating the fi ller materials for tissue re-growth, the primary concern should be focused on the immunocompatibility of the material. Lymphocyte T-cells and macrophages activate each other and induce immune suppressive eff ects. Polarized hydroxyapatite–barium titanate composite surfaces showed comparatively less macrophage activity than unpolarized surfaces. Lymphocytes isolated from human umbilical cord blood were cultured separately on both polarized and unpolarized samples. The macrophage with nitric oxide and myeloperoxidase showed less activity on polarized composite surfaces as compared to lipopolysaccharide of stimulated cells from which it can be inferred that the polarized composites showed immunocompatibility for which these materials can be used a preferred material in tissue engineering applications.
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Swain Subrat Kumar,Panda Subhasmita,Sahu Basanta Pravas,Mahapatra Soumya Ranjan,Dey Jyotirmayee,Sarangi Rachita,Misra Namrata 대한백신학회 2024 Clinical and Experimental Vaccine Research Vol.13 No.2
Purpose: Enterovirus 71, a pathogen that causes hand-foot and mouth disease (HFMD) is currently regarded as an increasing neurotropic virus in Asia and can cause severe complications in pediatric patients with blister-like sores or rashes on the hand, feet, and mouth. Notwithstanding the significant burden of the disease, no authorized vaccine is available. Previously identified attenuated and inactivated vaccines are worthless over time owing to changes in the viral genome. Materials and Methods: A novel vaccine construct using B-cell derived T-cell epitopes from the virulent polyprotein found the induction of possible immune response. In order to boost the immune system, a beta-defensin 1 preproprotein adjuvant with EAAAK linker was added at the N-terminal end of the vaccine sequence. Results: The immunogenicity of the designed, refined, and verified prospective threedimensional-structure of the multi-epitope vaccine was found to be quite high, exhibiting nonallergenic and antigenic properties. The vaccine candidates bound to toll-like receptor 3 in a molecular docking analysis, and the efficacy of the potential vaccine to generate a strong immune response was assessed through in silico immunological simulation. Conclusion: Computational analysis has shown that the proposed multi-epitope vaccine is possibly safe for use in humans and can elicit an immune response.
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