동국대학경주병원에서 분리된 각종 병원성 세균 및 항생제 감수성 양상

하경임,고은하,전창호,정병욱,안우섭,김우택,배정수,어경윤 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

We investigated characteristics of bacterial infection and antimicrobial suscerptibility patterns of clinical specimens in Dong Guk University Kyong Ju Hospital from october 1991 to december 1992. The types of clinical specimens requested for culture were as follows ; pus(34.2%), urine(29.6%), sputum(25.2%), blood(9.2%), etc. The most frequently isolated organisms were E. coli(17.6%), Pseudomonas(12.7%), S. aureus(12.2%), and CNS(11.2%), orderly. Predominant organisms from pus, urine and sputum were S.aureus, E. coli and Pseudomonas. Blood culture was requested 1,244 samples from 614 patients, 91 pathogeni organisms were isolated(14.8% from patient and 7.3% from requested clinical samples). E. coli was most frequently isolated(29.7%) and Salmonella typhi was noted 8.8% from the requested samples. The patterns of isolated organisms according to departments were as follows ; E.coli and Klebsiella were frequently isolated in internal medicine and general surgery, E.coli and Pseudomas in Neurosurgery, S. aureus and Pseudomonas in orthopedic surgery. In ICU, Pseudomonas was predominatly isolated and the rate of mixed infection was also high(16.4%). Most of gram-negative bacilli revealed relatively high susceptibility to Chlorampenicol, Amikacin, Tobramycin and Carbenicillin, but Acinetobacter were only susceptible to Carbenicillin and Tetrecyclin, and Serratia were to Carbenicillin and Amikacin while Salmonella were susceptible to all tested first drugs. The proportions of multi-drug resistant bacteria were 34.9% of Acinetobacter, 21.1% of Serratia, 20.0% of Pseudomonas and 15.4% of Citrobacter but Aztreonam was highly susceptible(84∼100%) except Acinetobacter. S. aureus and CNS were susceptible to Chlorampenicol, Oxacillin, Cephalothin and Vancomycin, especially, 100% susceptible to Vancomycin. But Methicillin reistant Staphylococcus aureus were very high(49%) inspite of new constructed hospital. Pneumococcus and Streptococcus species were relatively high susceptible to all tested drugs.

Effect of Increased Carbon Dioxide Gas in Atmosphere on the Antennal Response and Sex Pheromone Production of Helicoverpa armigera (Lepidoptera: Noctuidae)

Kyung San Choi,Seung Joon Ann,Soo Bin Kim,Bong Nam Jung,Han Cheol Lim,Dong Soon Kim 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04

The effect of increased carbon dioxide concentration in atmosphere was examined on the pheromone system of Helicoverpa armigera reared from egg stage to adult in three room. Two of three room (2×2×2 m) were treated with carbon dioxide gas as 600 ppm and 1,000 ppm, respectively. Mean of carbon dioxide concentration was 429.1 ppm in the control, 603.3 ppm for 600 ppm, and 1011.5 ppm for 1,000 ppm during experiment. Electroantenograph (EAG) test was conducted on 3-d-old male adults with air, hexane, and a series of their sex pheromone component, Z11-16Al, from 0.01 to 100 ng. The result was that male EAG responses of 600 and 1,000 ppm were 30.3% lower than that of control room. Production of Z11-16:Al was examined on about twenty 2-d-old virgin females. Carbon dioxide increases did not show a statistically significant difference. However, higher amount of sex pheromone was produced in females of 600 and 1,000 ppm. So, This experiment was replicated with different population reared again. The amount of the sex pheromone per female was 108.9 and 118.1 ng in control room, 139.8 and 141.8 ng in 600 ppm room, and 124.6 and 125.8 ng in 1,000 ppm room.

비만 중년 여성의 유산소운동에 따른 혈중 렙틴과 비만지표 및 심폐체력의 상관성

안의수 ( Eue Soo Ann ),이지영 ( Ji Young Lee ),박수현 ( Soo Hyun Park ),한태경 ( Tae Kyung Han ),강현식 ( Hyun Sik Kang ) 한국운동생리학회(구-한국운동과학회) 2006 운동과학 Vol.15 No.3

Effect of abatacept versus conventional synthetic disease modifying anti-rheumatic drugs on rheumatoid arthritis-associated interstitial lung disease

Kyung-Ann Lee,Bo Young Kim,Sung Soo Kim,Yun Hong Cheon,Sang-Il Lee,Sang-Hyon Kim,Jae Hyun Jung,Geun-Tae Kim,Jin-Wuk Hur,Myeung-Su Lee,Yun Sung Kim,Seung-Jae Hong,Suyeon Park,Hyun-Sook Kim 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.5

Background/Aims: To compare the effects of abatacept and conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) on the progression and development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Methods: This multi-center retrospective study included RA patients receiving abatacept or csDMARDs who underwent at least two pulmonary function tests and/or chest high-resolution computed tomography (HRCT). We compared the following outcomes between the groups: progression of RA-ILD, development of new ILD in RA patients without ILD at baseline, 28-joint Disease Activity Score with the erythrocyte sedimentation rate (DAS28-ESR), and safety. Longitudinal changes were compared between the groups by using a generalized estimating equation. Results: The study included 123 patients who were treated with abatacept (n = 59) or csDMARDs (n = 64). Nineteen (32.2%) and 38 (59.4%) patients treated with abatacept and csDMARDs, respectively, presented with RA-ILD at baseline. Newly developed ILD occurred in one patient receiving triple csDMARDs for 32 months. Among patients with RA-ILD at baseline, ILD progressed in 21.1% of cases treated with abatacept and 34.2% of cases treated with csDMARDs during a median 21-month follow-up. Longitudinal changes in forced vital capacity and diffusing capacity for carbon monoxide were comparable between the two groups. However, the abatacept group showed a more significant decrease in DAS28-ESR and glucocorticoid doses than csDMARDs group during the follow-up. The safety of both regimens was comparable. Conclusions: Abatacept and csDMARDs showed comparable effects on the development and stabilization of RA-ILD. Nevertheless, compared to csDMARDs, abatacept demonstrated a significant improvement in disease activity and led to reduced glucocorticoid use.

Slide Session : OS-NEP-03 ; Nephrology : Serum Phosphorus Level and Coronary Artery Calcifi cation in Subjects without Renal Dysfunction

( Kyung Sun Park ),( Jongha Park ),( Seong Hoon Choi ),( Jongmin Lee ),( Eun Seok Shin ),( Soe Hee Ann ),( Gillian B Singh ),( Jong Soo Lee ),( Hyun Chul Chung ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Serum phosphorus (P) level is associated with coronary artery calcifi cation as well as cardiovascular events in patients with chronic kidney disease. However, this relationship has been debated in normal subjects without renal dysfunction. Methods: A cross-sectional study was undertaken in 2,503 Korean subjects who underwent coronary multi-detector computerized tomography for screening and had estimated glomerular fi ltration rate >60 ml/min/1.73m². The study subjects were divided into 3 groups according to Agatston score: 0 (n=1582), >0 to 100 (n=613), and >100 (n=308). Serum P concentration was divided to 4 categories: =3.2, >3.2 to 3.6, >3.6 to 4.0 and >4.0 mg/dL. A baseline-category (Agatston score=0) logit model was applied to estimate relative risk ratio (RRR) for each serum P category (reference: =3.2 mg/ dL) with adjustment for age, sex, body mass index, corrected serum calcium, albumin, non-high density lipoprotein (HDL) and HDL cholesterol concentration. Results: Mean (±SD) age of subjects was 53.5±9.1 years and 36.9% were females. Increase in serum P level was not associated with the risk of Agatston scores of >0 to 100. When subjects with Agatston score =0 or >100 were analyzed, higher serum P levels were associated with higher risk of having Agatston scores of >100 (Figure). Serum P level of >4.0 mg/dL was a signifi cant and independent risk factor for Agatston scores of >100 (RRR 1.78, 95% confi dence interval 1.14-2.78). Conclusions: Higher serum P level may be associated with higher coronary artery calcifi cation even in healthy subjects with normal renal function. This fi nding needs to be validated in diverse populations.

Selegiline의 혈관이완반응에 대한 Ginkgo biloba Extract의 영향

김인경,안형수 동덕여자대학교 종합약학연구소 2003 동덕약학연구지 Vol.7 No.-

This research is made to identify the effects of Ginkgo biloba Extract on the vasorelaxation of selegiline which is the MAO_B inhibitor and used in the treatment of ischemic dementia. Investigation was made to find out whether Ginkgo biloba Extract in combined use with selegiline can reduce the orthostatic hypotension caused as side-effect when treated with selegiline alone. And it was tried to identify by what mechanism of action such a vasorelaxation of selegiline was taken place. The isolated rat thoracic aorta was constricted with phenylephrine (10^(-7) M) in organ bath. And it caused the vasorelaxation by injecting graded doses of selegiline (10^(-7)~3×10^(-4) M) to it as controls. The vasorelaxation of disrupted endothelial cell (pD2=4.43±0.13) is more decreased than that of intact endothelial cell (pD2=5.14±0.25). So it meant the endothelium-dependent vasorelaxation. In pretreatment with Nw-Nitro-L-Arginine Methylester·HCl (L-NAME) (10^(-5) M), inhibitor of NO production, the vasorelaxation of selegiline was significantly inhibited compared as that with the control (P<0.05). In pretreatment with indomethacin (10^(-5) M), inhibitor of prostacycline production, there were no effects. And the same result was produced in pretreatment with sulpiride (10^(-5) M), dopamine D₂ antagonist. Accordingly, the vasorelaxation is to be takne place by production and release of NO, not by the increase of dopamine. In pretreatment with Ginkgo biloba Extract (l0^(-5) g/mL), vasorelaxation was significantly inhibited in intact endothelial cell (P<0.01), but no significant inhibition in disrupted endothelial cell. As the experiment of measuring the blood pressure and heart rate of anaesthetized rats, in giving selegiline of 1, 3, 10 mg/kg i.v. as controls, there were temporal decrease of lood pressure and increase of heart rate. In pretreatment with sulpiride (10 mg/kg i.v.), there was significant inhibition compared as that with the control (P<0.05). Pretreatment with Ginkgo biloba Extract (10 mg/kg i.v.) had no significant inhibition. Therefore it shows that the selegiline inhibits the decomposition of dopamine in blood by inhibiting MAO_B only in living body and, as a result, by the increasing dopamine, it causes the relaxation of blood vessel, decrease of blood pressure, and increase of heart rate as the resultant compensatory mechanism. Accordingly, Ginkgo biloba Extract in combined use with selegiline reduces orthostatic hypotension, the virulence of selegiline, by inhibiting vasorelaxation and so it is expected to rise as desirable treatment of ischemic dementia.

성인의 부정교합 자각증상과 구강건강관련 삶의 질과의 관련성

김수경 ( Soo-kyung Kim ),박소영 ( So-young Park ),안지현 ( Jee-hyun Ann ),양지은 ( Ji-eun Yang ),이세현 ( Se-hyeon Lee ),정은서 ( Eun-seo Jung ) 한국치위생학회 2017 한국치위생학회지 Vol.17 No.2

Objectives: The purpose of this study was to investigate the effect subjective symptoms of malocclusion has on the patient`s quality of life related to oral health. Methods: A self-administered survey was conducted on adults aged 20 years, with a total of 308 copies of the response sheets analyzed. Results: The degree of subjective symptoms of malocclusion was highest in the group of those in their 20s when looked at across different age groups, and those who had a final education of middle school. In addition, the quality of life related to oral health was the highest in middle school graduates and among those in Gyeonggi province. The degree of malocclusion symptom according to oral health behavior was highest in 1-2 weeks of drinking when smoking in a smoking state, and quality of life related to oral health was higher in smokers than in non-smokers. The greater the subjective symptoms of malocclusion, the lower the quality of life related to oral health. Conclusions: It was found that the subjective symptoms of malocclusion decreased quality of life related to oral health. As such, quality of life related to oral health can be improved through aesthetic and functional improvement efforts to decrease the subjective symptoms of malocclusion.

한국의 제2형 당뇨병 환자에서 지속적 피하 인슐린 주입 치료가 산화적 스트레스에 미치는 영향

최수봉(Soo Bong Choi),최의광(Eui Kwang Choi),안승희(Seung Hee Ann),최미경(Mi Kyung Choi),박선민(Sun min Park) 대한내과학회 2000 대한내과학회지 Vol.58 No.5

Background : It is known that hyperglycemia increase oxidative stress. Korean type 2 diabetic patients usually appear to be insulin deficient and insulin resistant. The blood glucose control can be normalized by the intensive insulin therapy. It has been reported that hyperinsulinemia have harmful effects on oxidative stress. The purpose of this study was to determine whether continuous subcutaneous insulin infusion (CSII) therapy by insulin pump affects the defense mechanism of oxidative stress in Korean type 2 diabetic patients. Methods : Fasting blood from eighty three subjects was collected prior to starting CSII therapy using portable insulin pump and after hospitalization for 2 weeks. Serum and red blood cell lipid peroxide concentrations were analyzed by Yagi's methods. Serum tocopherol and vitamin C concentrations were measured by HPLC. Red blood cell glutathione peroxidase, superoxide dismutase and catalase activities were also measured. Results : The mean age of subjects were 50.0±10.9 years, and they had diabetes for 8.4±5.8 years. Their average body mass index was 23.4+2.7 ㎏/m2. Their blood glucose levels were not controlled by oral hypoglycemic agents, diet and exercise treatment. Patients were divided into two categories according to blood glucose levels prior to CSII treatment. One category consists of patients with less than 11.1 mmol/L of average daily blood glucose levels prior to CSII treatment (the controlled group). The other category consists of patients with more than 11.1 mmol/L of average daily blood glucose levels (the uncontrolled group). Patients in the uncontrolled group had higher serum lipid peroxide levels than those in the controlled group before CSII therapy. After 2 weeks of CSII therapy, oxidative stress was not changed in controlled and uncontrolled groups. Serum insulin levels of all patients were increased after CSII treatment, but the levels before and after treatments were in the normal range, not hyperinsulinemic. Also, serum insulin levels did not correlate with serum lipid peroxide levels regardless of CSII treatment. Average serum vitamin C levels were remarkably increased after the therapy in all patients, but average serum total tocopherol levels was not altered. Also, activities of antioxidant enzymes such as glutathione peroxidase, superoxide dismutase, and catalase were not significantly changed. Conclusion : The blood glucose levels were normalized with the normal ranges of serum insulin levels after two weeks of CSII treatment. However, serum lipid peroxide levels were not changed even though serum vitamin C levels were increased. It is concluded that the oxidative stress of Korean type 2 diabetic patients are not changed after two weeks of CSII treatment, but there may be possibility the longer duation of CSII therapy may gradually improve oxidative stress.(Korean J Med 58:548-559, 2000)

어머니의 자아존중감 및 양육행동과 아동의 자아존중감과의 상관연구

권현수,양성은,오종은,이미경,정안나,최선아 연세대학교 생활과학대학 1993 婦學 Vol.26 No.-

남성노인에 있어 심폐체력과 C-반응성 단백질과의 관련성

김도경 ( Do Kyung Kim ),안의수 ( Eue Soo Ann ) 한국운동영양학회 2007 Physical Activity and Nutrition (Phys Act Nutr) Vol.11 No.1