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Xiaoguang Li,Guanghong Li,Songan Zhang,Qiang Yuan 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.5
The combination of traditional ant colony algorithm in solving the optimization process to consume a large amount of time, easily falling into local optimal solution and convergence is slow and other disadvantages, while also generating a lot of useless redundant iterative code, operation efficiency is low. Therefore, ant colony optimization algorithm is proposed. The algorithm based on genetic algorithm has the ability to search the global ant colony algorithm also has a parallel and positive feedback mechanisms. Changes in the use of genetic algorithm selection operator, crossover operator and mutation operator action to determine the distribution of pheromone on the path, the ant colony algorithm for feature selection using support vector machine classifiers for evaluating the performance characteristics of the feedback sub-Variorum And by changing the pheromone iteration, parameter selection and increase the local pheromone update feature nodes guided the re-combination. The algorithm uses probability expectation values are obtained to meet under the conditions with minimal sensor nodes, and gives the optimal coverage and connectivity probability models and reasoning. The experimental results show that, the algorithm can not only use the least nodes complete the effective target area to be covered, and in reducing the network energy consumption is also greatly improved, simultaneously reduces the cyber source configuration, improve the network life cycle.
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Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling
Song, An,Wang, Yi,Jiang, Feng,Yan, Enshi,Zhou, Junbo,Ye, Jinhai,Zhang, Hongchuang,Ding, Xu,Li, Gang,Wu, Yunong,Zheng, Yang,Song, Xiaomeng Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.7
Ubiquitin D (UBD) is highly upregulated in many cancers, and plays a pivotal role in the pathophysiological processes of cancers. However, its roles and underlying mechanisms in oral squamous cell carcinoma (OSCC) are still unclear. In the present study, we investigated the role of UBD in patients with OSCC. Quantitative real-time polymerase chain reaction and Western blot were used to measure the expression of UBD in OSCC tissues. Immunohistochemistry assay was used to detect the differential expressions of UBD in 244 OSCC patients and 32 cases of normal oral mucosae. In addition, CCK-8, colony formation, wound healing and Transwell assays were performed to evaluate the effect of UBD on the cell proliferation, migration, and invasion in OSCC. Furthermore, a xenograft tumor model was established to verify the role of UBD on tumor formation in vivo. We found that UBD was upregulated in human OSCC tissues and cell lines and was associated with clinical and pathological features of patients. Moreover, the overexpression of UBD promoted the proliferation, migration and invasion of OSCC cells; however, the knockdown of UBD exerted the opposite effects. In this study, our results also suggested that UBD promoted OSCC progression through NF-κB signaling. Our findings indicated that UBD played a critical role in OSCC and may serve as a prognostic biomarker and potential therapeutic target for OSCC treatment.
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