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Veerendra C. Yeligar,K. Murugesh,Deepak Kumar Dash,Siva Shankar Nayak,B. C. Maiti,Tapan K. Maity 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
unripe whole fruits of Luffa tuberosa (Roxb.) or Momordica tuberosa (Roxb) Cogn.(Cucurbitaceae) were evaluated for the antidiabetic and hyperlipidemic potential in streptozotocin (STZ) induceddiabetic rats. Diabetes was induced by administration of intra-peritoneal injection of streptozotocin at a dose of55 mg/kg body weight. After the induction of diabetes aqueous extract of L.tuberosa (AELT) was administeredorally at doses of 250 and 500 mg/kg. body weight/day for a period of 14 days. The Fasting blood glucose (FBG)levels, serum insulin levels, changes in body weight, food and liquid intake were measured. In diabetic rats, theAELT exhibited significant reduction in blood glucose levels. Biochemical assay of plasma total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc),after the extract supplementation was confirmed by significant reduction in the levels of above mentionedhyperlipidemic indicators. This study focus on the efficacy of L.tuberosa fruits for the management ofexperimental STZ induced diabetic rats and provides the scientific basis of ancient herbal therapy and use of thesefruits as vegetable.KeywordsLuffa tuberosa (Roxb.), streptozotocin, antihyperglycemic activity, antihyperlipidemic activity