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- 저자 : Shorrosh, Basil (검색결과 1 건)
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An annotated database of Arabidopsis mutants of acyl lipid metabolism
McGlew, Kathleen,Shaw, Vincent,Zhang, Meng,Kim, Ryeo Jin,Yang, Weili,Shorrosh, Basil,Suh, Mi Chung,Ohlrogge, John Springer Berlin Heidelberg 2015 Plant cell reports Vol.34 No.4
<P><B><B><I>Key message</I></B></B></P><P><B>We have constructed and annotated a web-based database of over 280 Arabidopsis genes that have characterized mutants associated with Arabidopsis acyl lipid metabolism.</B></P><P><B>Abstract</B></P><P>Mutants have played a fundamental role in gene discovery and in understanding the function of genes involved in plant acyl lipid metabolism. The first mutant in Arabidopsis lipid metabolism (<I>fad4</I>) was described in 1985. Since that time, characterization of mutants in more than 280 genes associated with acyl lipid metabolism has been reported. This review provides a brief background and history on identification of mutants in acyl lipid metabolism, an analysis of the distribution of mutants in different areas of acyl lipid metabolism and presents an annotated database (ARALIPmutantDB) of these mutants. The database provides information on the phenotypes of mutants, pathways and enzymes/proteins associated with the mutants, and allows rapid access via hyperlinks to summaries of information about each mutant and to literature that provides information on the lipid composition of the mutants. In addition, the database of mutants is integrated within the ARALIP plant acyl lipid metabolism website (http://aralip.plantbiology.msu.edu) so that information on mutants is displayed on and can be accessed from metabolic pathway maps. Mutants for at least 30 % of the genes in the database have multiple names, which have been compiled here to reduce ambiguities in searches for information. The database should also provide a tool for exploring the relationships between mutants in acyl lipid-related genes and their lipid phenotypes and point to opportunities for further research.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00299-014-1710-8) contains supplementary material, which is available to authorized users.</P>
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