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Parasporin-4, A Novel Cancer Cell-killing Protein Produced by Bacillus thuringiensis
Kuniyo Inouye,Shiro Okumura,Eiichi Mizuki 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.2
Bacillus thuringiensis was isolated as a pathogen of the sotto disease of silkmoth larvae about a hundred years ago. Since then, this bacterium has attracted attentions of not only insect pathologists but also many other scientists who are interested in its strong and specific insecticidal activity. This has led to the recent worldwide development of B. thuringiensisbased microbial insecticides and insect-resistant transgenic plants, as well as a landmark discovery of parasporin, a cancer cellspecific cytotoxin produced by B. thuringiensis. In this review, we describe examination of interaction between inclusion proteins of B. thuringiensis and brush border membrane of insects using a surface plasmon resonance-based biosensor, identification and characterization of parasporin-4, the latest parasporin produced by the B. thuringiensis A1470 strain, and an effective method for preparing the parasporin-4 from inclusion bodies expressed in the recombinant Escherichia coli cells.