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Impact of White Matter Changes on Activities of Daily Living in Mild to Moderate Dementia
Moon, So Young,Na, Duk L.,Seo, Sang Won,Lee, Jun-Young,Ku, Bon D.,Kim, Seong Yoon,Park, Kyung Won,Shim, Yong S.,Youn, Young Chul,Chung, Chan-Seung,Cheong, Hae-Kwan,Choi, Seong Hye,Cha, Kyung Ryeol,Kim S. Karger AG 2011 European neurology Vol.65 No.4
<P>The association between white matter changes and activities of daily living (ADL) in a large, well-defined cohort of patients with mild-to-moderate dementia (either Alzheimer’s disease or subcortical vascular dementia) were investigated. A total of 289 patients were divided into three groups (140 mild, 99 moderate, and 50 severe) depending on the degree of white matter changes as indicated on brain magnetic resonance image scans. Further, we analyzed the three groups’ performances on basic and instrumental ADL. The degree of white matter changes was associated with greater age, hypertension, previous history of stroke, higher Hachinski Ischemic Score, worse global cognitive and functional status, and an increased impairment of basic ADL and instrumental ADL. The increased impairment with regard to the severe group’s performance on both the basic and instrumental ADL remained significant after adjustment for age and hypertension. Tasks involving physical activities were most significant. This was the first study investigating the association between white matter changes and ADL in a large, well-defined dementia cohort. The present study suggests that severe white matter changes may be associated with higher impairment on both basic and instrumental ADL.</P><P>Copyright © 2010 S. Karger AG, Basel</P>
Neutron Diffraction Study of Powders Prepared by Self-propagating High Temperature Synthesis
Park Yong,Kim Y S.,Y. D. Hahn,S. H. Shim,Lee J. S. 한국분말야금학회 2000 한국분말야금학회 학술대회논문집 Vol.2000 No.1
Non-stoichiometric ceramics of were prepared by self-propagating high temperature synthesis reaction with various processing conditions and their stoichometric numbers were determined by neutron diffraction. The neutron diffraction patterns were measured at room temperature using monochromatic neutrons with a wave length of 0.18339 nm from a Ge(331) mocochromator at a 90 degree take off angle. The Rietveld refinement of each pattern converged to good agreement (x2=1.88-2.24). The neutron diffraction analysis revealed the final stoichiometries of the ferrites were and respectively. This supports that final stoichiometric number of the self-propagating high temperature synthesis product can be controlled by the processing parameters during the combustion reaction.
Park, Hee Kyung,Na, Duk L.,Han, Seol-Heui,Kim, Ji-Young,Cheong, Hae-Kwan,Kim, Seong Yoon,Kim, Sang Yun,Hong, Chang Hyung,Kim, Do-Kwan,Ku, Bon D.,Moon, So Young,Lee, Jun-Young,Shim, Yong S.,Youn, Young The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.9
<P>With rapid population aging, the socioeconomic burden caused by dementia care is snowballing. Although a few community-based studies of Alzheimer's disease (AD) have been performed in Korea, there has never been a nationwide hospital-based study thereof. We aimed to identify the demographics and clinical characteristics of mild-to-moderate AD patients from the Clinical Research Center for Dementia of Korea (CREDOS) registry. A total of 1,786 patients were consecutively included from September 2005 to June 2010. Each patient underwent comprehensive neurological examination, interview for caregivers, laboratory investigations, neuropsychological tests, and brain MRI. The mean age was 74.0 yr and the female percentage 67.0%. The mean period of education was 7.1 yr and the frequency of early-onset AD (< 65 yr old) was 18.8%. Among the vascular risk factors, hypertension (48.9%) and diabetes mellitus (22.3%) were the most frequent. The mean score of the Korean version of Mini-Mental State Examination (K-MMSE) was 19.2 and the mean sum of box scores of Clinical Dementia Rating (CDR-SB) 5.1. Based on the well-structured, nationwide, and hospital-based registry, this study provides the unique clinical characteristics of AD and emphasizes the importance of vascular factors in AD in Korea.</P>
Kumbhar, Vijay S.,Nguyen, Van Quang,Lee, Yong Rok,Lokhande, Chandrakant D.,Kim, Do-Heyoung,Shim, Jae-Jin The Royal Society of Chemistry 2018 NEW JOURNAL OF CHEMISTRY Vol.42 No.18
<P>A honeycomb-like NiMoO4 nanoporous network electrode was synthesized on nickel foam using an electrodeposition method and used for the fabrication of asymmetric supercapacitors (ASCs). The growth process of the NiMoO4 nanostructure was controlled by varying the number of electrochemical cycles. The evolution of the NiMoO4 nanoflakes with the electrochemical cycles was confirmed by field emission scanning electron microscopy. The supercapacitive properties of NiMoO4 nanostructure were measured by cyclic voltammetry, galvanostatic charge discharge, and electrochemical impedance spectroscopy. The well-grown NiMoO4 nanoporous network exhibited a highest specific capacitance of 1475 F g<SUP>−1</SUP> at a current density of 1 A g<SUP>−1</SUP> in an aqueous KOH electrolyte with a good rate capability of 72.8% when the current density was increased 20 fold. The nanoporous network also exhibited a capacitive retention of 87.9% after 5000 charge-discharge cycles at a fixed current density of 20 A g<SUP>−1</SUP>. A NiMoO4//reduced graphene oxide (rGO)-based solid state ASC was fabricated using a poly(vinyl alcohol)-KOH gel electrolyte. The NiMoO4//rGO ASC delivered a maximum energy density of 45 W h kg<SUP>−1</SUP> and a power density of 14.5 kW kg<SUP>−1</SUP> as well as an electrochemical stability of 84% after 5000 cycles, highlighting the potential of NiMoO4//rGO ASCs for portable electronic applications.</P>