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Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages
Ryu, Jae-Ha,Lee, Hwa-Jin,Jeong, Yeon-Su,Ryu, Shi-Yong,Han, Yong-Nam The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.4
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum
Ryu, Geon-Seek,Ju, Jeung-Hoon,Park, Yong-Ju,Ryu, Shi-Yong,Choi, Byoung-Wook,Lee, Bong-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-Ο-$\beta$-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity ($IC_{50}$, 40 $\mu$M), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity ($IC_{50}$, 0.38 $\mu$M).
Ryu, Shi-Yong,Lee, Hyun-Sun,Kim, Young-Kyoon,Kim, Sung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5
All fifteen flavonoids (1-15) have been isolated from the roots of Sophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15, in vitro. By means of spectral analyses, particularlyby the aid of various two dimensional NMR experiments, all $^1H-NMR$ ad $^{13}C$ -NMR signals of 1-15 were completely assigned, and thus the structures of 1-15 were established unambiguously.
Antiviral Activity of Triterpenoid Derivatives
Ryu, Shi-Yong,Lee, Chong-Kyo,Ahn, Jong-Woong,Lee, Seung-Ho,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1993 Archives of Pharmacal Research Vol.16 No.4
3-Oxo or/and 11-oxo derivatives of natural 3-hydroxy triterpense, i.e., 3-oxoursolic acid la, 11-oxoursolic acid lb, 3, 11-dioxoursolic acid ic, 3-oxobetulinic acid lla and 3-oxopomolic acid Via were exhibited to show an increased anti-HSV-1 activity in vitro, four to ten times as much as corresponding parent 3-hydroxy compounds.
Antitumor Activity of Psorelea corylifolia
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.
The Structure of Kushenol M from Sophora flavescens
Ryu, Shi-Yong,Lee, Seung-Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueg-Geun,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.1
The linkage pattem of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid from Sophora flavescens was established by the aid of 2-D NMR techniques, especially DEPT, ${13}C-^1H$ COSY and COLOC experiments. Thus, I was unequivocally determined as (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulyflavanonol.
Antitumor Triterpense from Medicinal Plants
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Seung-Ho,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
Thirteen kinds of naturally occurring or derivatised thiterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells, i.e., A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15, in vitro. Ursonic acid III, betulinic acid VIII, betulonic acid X and glycrrhetinic acid XI were exhibitied a marked inhibition on cell growth.