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Ryu, Shi-Yong,Lee, Hyun-Sun,Kim, Young-Kyoon,Kim, Sung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5
All fifteen flavonoids (1-15) have been isolated from the roots of Sophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15, in vitro. By means of spectral analyses, particularlyby the aid of various two dimensional NMR experiments, all $^1H-NMR$ ad $^{13}C$ -NMR signals of 1-15 were completely assigned, and thus the structures of 1-15 were established unambiguously.
Antiviral Triterpenes from Prunella vulgaris
Ryu, Shi-Yong,Lee, Chong-Kyo,Lee, Chong-Ock,Kim, Hae-Soo,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.3
Two triterpenes 1 and 2 with antiviral activity against Herpes simplex virus type 1 in vitro were isolated from Prunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect when vero cells were exposed to them for 72 hours after viral challenge. They were identified as betulinic acid (1) and $2\alpha, 3\alpha$-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as $EC_{50}=30\;\mu$g/ml(1) and $8\;\mu$g/ml(2), respectively by plaque reduction assay.
Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages
Ryu, Jae-Ha,Lee, Hwa-Jin,Jeong, Yeon-Su,Ryu, Shi-Yong,Han, Yong-Nam The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.4
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
Antitumor Activity of some Phenolic Components in Plants
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Lee, Seung-Ho,Ahn, Jong-Woong,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.1
The activity-guided fractionation of some medicinal plants led to yield five kinds of natural stilbene compounds namely 3, 5-dihydroxy-4'-methoxystillbene(I), rhapontigenin(II), reveratrol(III), rhaponticin(IV) and piceid(V) and two common flavonoids, apigenin(VI) and luteolin(VII) as active principles of the antitumor property, in vitro, against five kinds of human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15.
The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum
Ryu, Geon-Seek,Ju, Jeung-Hoon,Park, Yong-Ju,Ryu, Shi-Yong,Choi, Byoung-Wook,Lee, Bong-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-Ο-$\beta$-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity ($IC_{50}$, 40 $\mu$M), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity ($IC_{50}$, 0.38 $\mu$M).
Ryu, Jae-Ha,Ryu, Shi-Yong,Han, Yong-Nam,Han, Byung-Hoon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.1
A new celastraceae alkaloid, euojaponine C has been isolated from the methanol extract of the root bark of Euonymus japonica. With the relative stereochemistry of euojaponine C established by NOESY data, the absolute stereochemistry has been determined by circular dichroism (CD) exciton chirality method. The CD of the 2, 5-bis-phenyl benzoate of triacetonide derived from the LiAlH$_{4}$, hydrolysate, euonyminol shows that the configuration of C-2 and C-5 are both R.
Antitumor Activity of Psorelea corylifolia
Ryu, Shi-Yong,Choi, Sang-Un,Lee, Chong-Ock,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
The activity-oriented fractionation of Psoralea corylifolia led to an isolation of a (+) bakuchio 1 as an activ eprinciple of its antitumoral property in vitro 1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines, i. e. the A549, SK-OV-3, SK-MEL-2, XF-498 and HCT15. The synthesized 2, 3-epoxide of (+)-bakuchiol 3 showed the similar activity as the (+) bakuchiol 1, whereas the other oxidation derivatives 4 and 5 including the acetyl (+) bakuchiol 2 showed a decreased activity.
Antitumor activity of Trichosanthes kirilowii
Ryu, Shi-Yong,Lee, Seung-Ho,Lee, Sang-Un,Lee, Chong-Ock,No, Zaesung,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The activity fractionation upon the MeOH extract of the root of trichosanthes kirilowii led to the isolation of eight cucurbitane tritepense namely cucurbitacin .betha. (I), isocucurbitacin .betha.(II), cucurbitacin D(III), isocucurbitacin D(IV), 3-epi-isocucurbitacin .betha(V), dihydrocucurbitain .betha. (VI), dihydroisocucurgbitachin .betha. (VII) and dihydrocucurbitacin E (VIII), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, Sk-OV-3, Sk-MEL-2, XF-498 and HCT 15, with an exceptionally high potency.
Monoamine Oxidase-A Inhibitors from Medicinal Plants
Ryu, Shi-Yong,Han, Yong-Nam,Han, Byung-Hoon The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.3
Thirty kinds of medicinal plants were screened to examine inhibitory activities on rat brain monoamine oxidase A, using serotonin as a substrate. As active principles, various kinds of stilbenes were isolated from Veratri Rhizoma, Reynoutriae Radix and Rhei undulati Rhizoma, and several kinds of flavonoids from Sophorae Flos, Chrisanthemi Flos and Glycine max. Among the compounds isolated, resveratrol(I) strongly inhibited MAO-A competitively, and its $IC_{50}$ and Ki values were 2 ${\mu}M$ and 2.5 ${\mu}M$, respectively. Inhibitory potencies towards MAO-A of some stilbenes and flavonoids were also compared.
The Structure of Kushenol M from Sophora flavescens
Ryu, Shi-Yong,Lee, Seung-Ho,No, Zaesung,Kim, Kye-Young,Lee, Sueg-Geun,Ahn, Jong-Woong The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.1
The linkage pattem of two side chains i.e., a isopentenyl and a lavandulyl group in kushenol M(I), a flavonoid from Sophora flavescens was established by the aid of 2-D NMR techniques, especially DEPT, ${13}C-^1H$ COSY and COLOC experiments. Thus, I was unequivocally determined as (2R, 3R)-5, 7, 2', 4'-tetrahydroxy-6-isopentenyl-8-lavandulyflavanonol.