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RISS 인기검색어
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- 저자 : Sherif Elzawawy (검색결과 2 건)
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Sherif Elzawawy,Gehan Khedr,Basma Elsabaa 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.2
Purpose: To evaluate the progression free survival, response rate and toxicity for patients who were treated with conventional therapy combined with metronomic chemotherapy. Methods: patients received either chemotherapy followed by maintenance metronomic chemotherapy with or without hormonal therapy or primarily treated with hormonal therapy concomitant with metronomic chemotherapy. Metronomic chemotherapy consists of cyclophosphamide 50 mg tablet daily and methotrexate 2.5 mg twice daily on days 2 and 5 weekly, continued until disease progression or development of unacceptable toxicity. Results: after median follow up of 18 months, 40 patients were assessed. The progression free survival was 52.5% and the median time to disease progression was 10.4 months. The overall clinical benefit (complete response [CR]+partial remission [PR]+stable disease [SD]) was 52.5 % with no G3 or G4 toxicities encountered for metronomic therapy. The median time to disease progression was 12.5 months for estrogen receptor (ER)+ve, human epidermal growth factor receptor 2 (Her2)–ve (progression free survival [PFS]: 67.5%) compared to 8 months for ER+ve, Her2+ve (PFS: 10%), 9 months for ER–ve, Her2+ve (PFS: 10%) and 8 months for triple negative (PFS: 12.5%). The difference was statistically significant (P=0.018). Conclusion: maintenance metronomic cyclophosphamide and methotrexate demonstrated efficacy and provided durable disease stabilization especially for ER positive patients. The low costs and minimal toxicity allow patients to continue treatment for several months and support its use as an additional therapeutic tool.
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Metronomic capecitabine versus doxorubicin in advanced hepatocellular carcinoma
Gehan Abd Elatti Khedr,Sherif Farouk Elzawawy,Ahmad Gaber Gowil,Amany Saleh Elyamany,Mohamed Eshafei 대한종양외과학회 2016 Korean Journal of Clinical Oncology Vol.12 No.1
Purpose: We evaluated oral metronomic capecitabine (MC) compared to intravenous doxorubicin in patients with advanced or metastatic hepatocellular carcinoma (HCC). Methods: From January 2013 to December 2015, patients with Child-Pugh class A or early B were randomized either to MC group (500 mg twice daily continuously) or doxorubicin group (60 mg∕m2 every 21 days). Results: Forty patients were included in each group. The baseline clinical characteristics of the enrolled patients were well balanced between the two groups. No complete response (CR) was reported in either group. In MC group, 2 patients (5%) had partial response (PR), 25 patients (62.5%) stable disease (SD) and 27 patients (67.5%) had disease control. In doxorubicin group, 4 patients (10%) achieved PR, 24 patients (60%) SD and 28 patients (70%) had disease control. The 6 months overall survival (OS) was 77.5% for MC and 75% for doxorubicin. The one year OS was 47.5% for MC and 42.5% for doxorubicin (P=0.521). The median OS survival was 10.2 months for MC and 9.6 months for doxorubicin (95% confidence interval, 3.2–6.5). The 6 month progression-free survival (PFS) was 45% for MC and 50% for doxorubicin. The one year PFS was 12.5% for MC and 7.5% for doxorubicin (P=0.289). The median time to progression was 3.4 months for MC and 3.1 months for doxorubicin. On multivariate analysis no significant impact for tumor stage, previous transhepatic arterial chemoembolization, portal vein thrombosis or median baseline alpha fetoprotein on OS. Conclusion: MC showed response rate and survival outcome comparable to doxorubicin in advanced HCC but with a more favorable toxicity profile.
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