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Shang-Cheng Hung 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Cell surface carbohydrates play significant roles in a number of biologically importantprocesses. Heparan sulfate (HS), for instance, is a ubiquitously distributed polysulfatedpolysaccharide that is involved, among others, in the initial step of herpes simplex virus type1 (HSV-1) infection. The virus interacts with cell surface HS to facilitate host cellattachment and entry. 3-O-Sulfonated HS was discovered to function as an HSV-1 entryreceptor. A complete understanding of these interactions necessitates the chemical synthesisof such oligosaccharides, but remains challenging. Here, we present a convenient approachfor the synthesis of two irregular 3-O-sulfonated HS octasaccharides making use of a keydisaccharide intermediate to acquire different building blocks for the oligosaccharide chainassembly. Despite substantial structural differences, the prepared 3-O-sulfonated sugarsblocked viral infection in a dosage-dependent manner with remarkable similarity.
Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.