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점성토(c-Ф 흙)로 뒤채움된 중력식 옹벽에서 인장규열을 고려한 수평토압 : 배수해석
정성교,남선우,김문규,오병수 東亞大學校 建設技術硏究所 1997 硏究論文集 Vol.21 No.2
Coulomb’s theory has been usually used in practice for design of retaining walls. This theory assumed that the lateral earth pressure was a triangular distribution, because the point of applying the thrust could not be abtained straightforward. However, the results of laboratory and filed tests proved that the lateral earth pressure was not a triangular distribution. In this study, for gravity walls with inclined backface, backfilled by c - ø soils with inclined surface, an analytical method for earth pressure has been derived. This method applied the flat arching concept and the Coulomb’s wedge, under drained condition, for the cases of considering tension crack. In addition, this paper is dealt with comparing the new analytical solution with existed theories for some cases.
점성토(c-ø흙)로 뒤채움된 중력식 옹벽에서 인장균열을 고려한 수평토압 : 배수해석 Drained Analysis
정성교,남선우,김문규,오병수 동아대학교 건설기술연구소 1998 硏究報告 Vol.22 No.1
Coulomb's theory has been usually used in practice for design of retaining walls. This theory assumed that the lateral earth pressure was a triangular distribution, because the point of applying the thrust could not be abtained straightforward. However, the results of laboratory and filed tests proved that the lateral earth pressure was not a triangular distribution. In this study, for gravity walls with inclined backface, backfilled by c-ø soils with inclined surface, an analytical method for earth pressure has been derived. This method applied the flat arching concept and the Coulomb's wedge, under drained condition, for the cases of considering tension crack. In addition, this paper is dealt with comparing the new analytical solution with existed theories for some cases.
상악골과 하악골에 각각 발병한 섬유성이형성증 치험 2례
박노부,문선혜,남동석,이용오,서연호,김우철 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.4
The fibrous dysplasia of bone is a benign, slow growing, perplexing tumor of bone that replace the normal bone by the fibrous tissue composed of collagen fibers, fibroblasts and containing variable amount of mineralization. A fibrous dysplasia tends to occur more frequently in women than men and to be seen more in maxilla than mandible. This tumor may obliterate maxillary sinus and extend to the infraorbital area, zygoma but may not obliterate the nasal cavity. And this tumor may expand the cortical plate of the mandible, mandibular cannal and may involve to the condylar head so that facial asymmetry is provoked. Ideal treatment of the fibrous dysplasia is the surgical intervention. Because it is a diffuse lesion the complete excision is difficult, so the conservative osseous contouring is recommended. We treated two patients, one was a 18-year-old female with fibrous dysplasia in maxilla involving zygoma, infraorbital rim and maxillary sinus, the other was a 32-year-old female with fibrous dysplasia in mandibular posterior area. We operated the former by conservative surgery with osseous contouring and the latter by reconstructive surgery with titanium mesh and plate after mandibular resection under general anesthesia. We obtained successful functional and esthetic results and no recurrence was seen in two years postoperative follow up.
Woo, Seon Rang,Lee, Hyo-Jung,Oh, Se Jin,Kim, Suyeon,Park, Sang-Hyo,Lee, Jaeyoon,Song, Kwon-Ho,Kim, Tae Woo Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Cancer immunoediting enriches NANOG expression in tumor cells, resulting in multi-drug resistance and stem-like phenotypes. We previously demonstrated that these NANOG-associated phenotypes are promoted through HDAC1 transcriptional upregulation. In this study, we identified that NANOG also contributes to the stabilization of HDAC1 protein through the AKT signaling pathway. NANOG-AKT axis leads to phosphor-dependent inactivation of CHFR, an E3 ligase for HDAC1 protein, and thereby inhibiting the ubiquitin-mediated degradation of HDAC1. Furthermore, AKT inhibition disrupts HDAC1 WT-mediated phenotypes but had no effect on the phenotypes mediated by HDAC1 FM, a mutant that is unable to interact with CHFR. Critically, we applied a catalytic dead mutant, HDAC1-H141A, to uncover that HDAC1 confers immune-resistance, drug-resistance and stem-like phenotype in tumor cells through its catalytic activity. Collectively, our results establish a firm molecular link in immune-edited tumor cells among NANOG, AKT, CHFR, and HDAC1, identifying HDAC1 as a molecular target in controlling NANOGHIGH immune-refractory cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NANOG contributes to stabilization of HDAC1 protein through AKT signaling pathway. </LI> <LI> NANOG-AKT axis leads to phosphor-dependent inactivation of CHFR, which is an E3 ligase for HDAC1 protein. </LI> <LI> HDAC1 confers immune-resistance, drug-resistance and stem-like phenotype through its catalytic activity. </LI> <LI> AKT inhibition disrupts HDAC1-mediated multi-resistance and stem-like phenotype. </LI> </UL> </P>