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Polysaccharide-based Nano-PAMP Technology for Cancer Immunotherapy
Sejin Son(손세진) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Microbial pathogens present “danger” signals at the site of infection and confers protective immunity by inducing proinflammatory cytokines and mobilizing leukocytes. During microbial infection, pathogen associated molecular patterns (PAMPs) activate pattern recognition receptors (PRRs) expressed on innate immune cells, such as dendritic cells (DCs), leading to the production of proinflammatory cytokines, including IL-1β, IL-6, and IL-23, that promote the differentiation and stabilization of T helper 17 (Th17) cells. We have recently reported the development of Saccharomyces cerevisiae (S. cerevisiae) mannan-based nanocapsules (Mann-NC) for subcutaneous delivery of mRNA-based vaccines against cancer. We also demonstrate here that Mann-NC composed of mostly mannan (without any other cargo) is a potent nano-PAMP for Dectin-2 and TLR-4 activation and that intratumoral administration of Mann-NC generates robust Th17 responses in favor of antitumor effects. PAMP-PRR interaction is controlled by the geometry, nanoscale arrangement, and architecture of PAMP on Mann-NC for multivalent surface PAMP arrangement with structural flexibility for favorable PRR engagement.
Vesosomal drug delivery for controlled and sustained release of multiple components
Jingyeong Yun(윤진경),Deborah Lee(이드보라),Seoyoon Song(송서윤),Suheon Kim(김수헌),Mina Lee(이민아),Eunsu Kim(김은수),Sunhee Yoon(윤선희),Han-Ul Kim(김한울),Sejin Son(손세진),Hyun Suk Jung(정현석),Yun Suk Huh(허윤석),Tae-Joon Jeon(전태 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11