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A psycho-pharmacological study of BRHAT VATACINTAMANI RASA classical ayurvedic drug
Islam, M. Naimul,Sattar, Mafruhi,Haque, Sabera,Shahriar, Masum,Choudhuri, Msk Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.2
The psycho-pharmacological effect of BRHAT VATACHINTAMANI RASA (BVC) an Ayurvedic preparation was investigated, both in animal and clinical models. It was observed that BVC possess a sedative or quitening effect in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the amphetamine treated animals. This was further evident by increase in climbing out time and taming effect on animal in isolation induced aggression test. Apart from very high dose it seems have little effect on pentobarbital sleeping time and narcotic analgesic test. The drug BVC increases performance of the animal in forced locomotor test. The effect of VATACHINTAMANI RASA on clinical study was not significant.
Preliminary pharmacological evaluation of an Ayurvedic formulation Dasamularista
Rajia Sultana,Choudhuri M Shahabuddin Kabir,Sattar Mafruhi,Shahriar Masum Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.3
In this study the Ayurvedic formulation Dasamularista was studied for its preliminary pharmacological properties using laboratory mice. Dasamularista showed a decrease in food intake and stool formation, while the water content of stool and water intake was higher and the volume of the urine was less. Dasamularista in a slight extent reduced the intestinal motility. This constipating effect was further supported by the significant anti-diarrhoeal property of the formulation in castor oil induced dairrhoea. The tested formulation markedly increased the latent period of diarrhoea and reduced the purging index value. Dasamularista did not alter the acetic acid induced abdominal writhing. Significant reduction on the onset of sleeping time and increased duration of sleep was observed in pentobarbital induced sleeping time test.
Neuropharmacological study of some Ayurvedic medicinal plants
Hannan, JMA,Shahriar, Masum,Islam, M Naimul,Sattar, Mafruhi,Haque, Sabera,Choudhuri, MSK Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.1
Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested in mice for possible neuropharmacological efficacy. In the present experiments it was observed that a number of plant tested causes a significant level of Central Nervous System (CNS) depression, in that it significantly decreased the spontaneous Motor activity, and also lowered the exploratory behavior of the treated animals. Terminalia chebula (HAA), Terminalia bellerica (BHA), Emblica officinalis (AA), Piper longum 1. (PP). exhibited depressant action of on the CNS. Apart from them a mild to moderate degree of depression was evident as a consequence of administration of Zingiber officinale Rosc (SUT), Piper nigrum L. (MRC). However, none of the plant tested did not exhibit significant effects on pentobarbital induced narcosis, and this indicated that the sedating effects of the drug was not associated with the risk of fatal consequences on overdose.
Some pharmacological findings of non therapeutic importance of an Ayurvedic preparation Chandanasav
Chakraborty, Sharmila,Rajia, Sultana,Choudhuri, M. Shahabuddin Kabir,Hossain, M. Faruk,Sattar, Mafruhi,Shrestha, Tripti Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.2
Chandanasav is an Ayurvedic preparation slightly reduced the gastrointestinal motility at the 15 min time interval. It increased the latent period of castor oil induced diarrhoea, slightly decreased number of stool count and lowered the purging index values. Chandanasav significantly reduced the onset and increased the duration of pentobarbital induced sleeping time. No significant analgesic effect was observed from the hot plate study Thus it may have mild constipating and central nervous system depressant activity without any effect on peripheral nervous system.
Pharmacological study of 'treenoponchomul'-an Ayurvedic diuretic preparation
Haque, Sabera,Hannan, JMA,Shahriar, Masum,Islam, M Naimul,Sattar, Mafruhi,Choudhuri, MSK Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.1
The pharmacological effects of an Ayurvedic diuretic drug 'Treenoponchomul' (TPM) was investigated in animal model. The pharmacological actions of the test drug along with that of the components thereof, on the Central Nervous System (CNS) were studied. The drug under study TPM showed little effect on the CNS, the same can not be said about the components. The most prominent CNS depressant effect was observed with Saccharum officinarum Linn. (EE) in that it lowered the spontaneous motor activity as well the exploratory -behavior of the animals. An exploration retarding effect of moderate degree, was evident with Imperata cylindrica Beauv. (UU), and Phragmites maxima Blatter & McCann (NN). Although the test drug did not alter the normal locomotor and/ or exploratory behavior of the treated animals, it did significantly (p<0.01) lower the locomotion of the amphetamine induced hyperactive animals. TPM along with its components (especially Desmostachya bipinnata Stapf. Root, KU), significantly reduced the gastro-intestinal motility of the treated animals (p<0.01). The test drug and its components lowered the body weight of the treated animals, on being administered chronically (30 days), with EE being the only exception.