RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI등재

        Novel Animal Models of Atherosclerosis

        Amir Rezvan,Sanjoli Sur,Hanjoong Jo 대한의용생체공학회 2015 Biomedical Engineering Letters (BMEL) Vol.5 No.3

        Atherosclerosis remains a significant cause of mortality andmorbidity in the world. It is now well established thatatherosclerosis is an inflammatory disease preferentiallyoccurring in curved or branched arterial regions, whereasstraight parts of the arteries are protected, suggesting a closerelationship between flow and atherosclerosis. Animalmodels of atherosclerosis are an important tool to understandthe pathophysiology of atherosclerosis and identify newtherapies. Various animal models have been used throughoutthe years, each contributing to scientific progress in the field,including different species such as pigeon, mice, rabbit,pig and nonhuman primates. In many cases, one or acombination of multiple interventions, including geneticmanipulation, hypercholesterolemia inducing diets, or surgicalinterventions are employed to induce atherosclerosis or toaccelerate or vary the severity and complexity of the lesions. In recent years, new animal models have been developed toaddress specific needs in the field of atherosclerosis research. Some of these models use surgical interventions to create adisturbed flow profile, and a few models have used largeranimals such as minipigs. While PCSK9 inhibition isbeing used as a new therapy for lowering cholesterol inhyperlipidemic patients, over-expression of PCSK9 hasrecently been exploited to induce atherosclerosis in animalmodels. No animal model can perfectly mimic the process inhuman disease, however each model may be successfullyused to elucidate a particular aspect of the pathophysiology. It is essential to understand the strengths and weaknesses ineach model in

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼