http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Sanam Arami (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Preparation of optimized Naproxen nano liposomes using response surface methodology
Saeed Ghanbarzadeh,Sanam Arami,Arash Khorrami 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.1
The aim of this study was to prepare and optimizea liposomal delivery system for Naproxen (NPX), apractically water insoluble drug. NPX liposomes, whichwere consisted of cholesterol (CH) and phosphatidylcholine(PC) in different molar ratios, were prepared by modifiedethanol injection method and optimized employingresponse surface methodology (RSM). Proportion ofPC:CH and total lipid:drug ratio were selected as theindependent variables while the particle size (PS), encapsulationefficiency percent (EE%) and drug release of theliposomes over 24 h (D24h) were considered as dependentvariables. The effects of PC:CH and total lipid:drug ratioswere studied and optimized to obtain the liposomal vesicleswith desired quality. Graphical response surface and contourplots were also employed to understand the interactionof different variables. The optimum points for the variableswere obtained from the optimization plot. The mean PS,EE% and D24h of NPX liposomes were about 178.11 nm,53.14 and 46.62 % respectively. The results indicated thatPC:CH and total lipids:drug ratios were the major contributingvariables for EE% and D24h. However, only PC:CHratio was the main contributing variable for PS. The optimumformulation of NPX liposomes, in which PC:CH ratioand lipids:drug ratio were 3.81 and 2.98 respectively, hadhigh EE% (58 %) and D24h ([50 %) as well as appropriatePS (\162.4 nm). Ethanol injection method besides RSM,are simple, rapid and beneficial approaches for liposomepreparation and optimization.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
