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Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro
Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8
Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.
Jia-Yu Lv,Ning-Ning Zhang,Ya-Wei Du,Ying Wu,Tian-Qiang Song,Ya-Min Zhang,Yan Qu,Yu-Xin Liu,Jie Gu,Ze-Yu Wang,Yi-Bo Qiu,Bing Yang,Da-Zhi Tian,Qing-Jun Guo,Li Zhang,Ji-San Sun,Yan Xie,Zheng-Lu Wang,Xin 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.1
Purpose: The aim of this study was to compare the efficacy of liver transplantation (LT) and liver resection (LR) for hepatocellularcarcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and to investigate risk factors affecting prognosis. Materials and Methods: A total of 94 HCC patients with PVTT type I (segmental PVTT) and PVTT type II (lobar PVTT) were involvedand divided into LR (n=47) and LT groups (n=47). Recurrence-free survival (RFS) and overall survival (OS) were comparedbefore and after inverse probability of treatment weighting (IPTW). Prognostic factors for RFS and OS were explored. Results: Two treatment groups were well-balanced using IPTW. In the entire cohort, LT provided a better prognosis than LR. Among patients with PVTT type I, RFS was better with LT (p=0.039); OS was not different significantly between LT and LR(p=0.093). In subgroup analysis of PVTT type I patients with α-fetoprotein (AFP) levels >200 ng/mL, LT elicited significantly longermedian RFS (18.0 months vs. 2.1 months, p=0.022) and relatively longer median OS time (23.6 months vs. 9.8 months, p=0.065). Among patients with PVTT type II, no significant differences in RFS and OS were found between LT and LR (p=0.115 and 0.335,respectively). Multivariate analyses showed treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase(AST) levels to be risk factors of RFS and treatment allocation (LR), AFP and AST as risk factors for OS. Conclusion: LT appeared to afford a better prognosis for HCC with PVTT type I than LR, especially in patients with AFP levels>200 ng/mL.
Entropic Image Thresholding Segmentation Based on Gabor Histogram
( Sanli Yi ),( Guifang Zhang ),( Jianfeng He ),( Lirong Tong ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.4
Image thresholding techniques introducing spatial information are widely used image segmentation. Some methods are used to calculate the optimal threshold by building a specific histogram with different parameters, such as gray value of pixel, average gray value and gradient-magnitude, etc. However, these methods still have some limitations. In this paper, an entropic thresholding method based on Gabor histogram (a new 2D histogram constructed by using Gabor filter) is applied to image segmentation, which can distinguish foreground/background, edge and noise of image effectively. Comparing with some methods, including 2D-KSW, GLSC-KSW, 2D-D-KSW and GLGM-KSW, the proposed method, tested on 10 realistic images for segmentation, presents a higher effectiveness and robustness.
Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
San-Qing Lin,Zhong-Liu Zhou,Hua-lin Zhang,Wen-Qing Yin 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.5
Depression is the most common psychiatric comorbidity in patients. Searching for antidepressant drugs from natural products is very important for the treatment of this disease. The ethanol extract and its fractions of Cyperus rotundus were evaluated for antidepressant activities in mice by our group. The aim of this study was to investigate the potential active components of C. rotundus. The extraction and solvent partition of the rhizomes of C. rotundus, and repeated column chromatography for n-BuOH fraction yielded three new phenolic glycosides, rotunduside D (1), rotunduside E (2), and rotunduside F (3). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. The potential antidepressant activity of all the isolated compounds was evaluated. In the despair mice models, rotunduside F (3) showed significant antidepressant activity at the dosage of 50 mg/kg, which was close to the positive control fluoxetine (20 mg/kg).
Zhang Xiang-rong,Chen Xiao-yan,Hu Lian-Dong,Tang Xing,Li San-Ming,Zhong Da-fang The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.8
The aim of this study was to compare two formulations of film-coated pellets containing c1arithromycin after single oral dose study in healthy male volunteers. Two formulations with different coating polymers were prepared: formulation-1 (F-1) was prepared by incorporating three kinds of pH-dependent gradient-release coated pellets into capsules and formulation-2 (F-2) was prepared by coated with an insoluble semiosmotic film. Release profiles of filmcoated pellets were evaluated using paddle method under different conditions. Pharmacokinetic profiles of these formulations were obtained in three healthy male volunteers and compared to commercially available immediate release (IR) tablets. The relative bioavailability based on the $AUC_{0-24h}$ was found to be $96.2\%\;and\;58.7\%$ for F-1 and F-2 compared with IR, and the $T_{max}$ was delayed.
Byoung-San Moon,Aswathy Ammothumkandy,Naibo Zhang,Lei Peng,Albina Ibrayeva,Maxwell Bay,Athira Pratap,박홍주,Michael Anthony Bonaguidi,Wange Lu 대한이비인후과학회 2018 Clinical and Experimental Otorhinolaryngology Vol.11 No.4
Objectives. Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a function of age. Methods. The expression of Nestin and Ki67 was examined in sequentially dissected cochlear modiolar tissues from mice of different ages (from postnatal day to 24 weeks) and the sphere-forming populations from the SGNs were isolated and differentiated into different cell types. Results. There were significant decreases in Nestin and Ki67 double-positive mitotic progenitor cells in vivo with increasing mouse age. The SGNs formed spheres exhibiting self-renewing activity and multipotent capacity, which were seen in NSCs and were capable of differentiating into neuron and glial cell types. The SGN spheres derived from mice at an early age (postnatal day or 2 weeks) contained more mitotic stem cells than those from mice at a late age. Conclusion. Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice.
장성규,SAN MAR LAR,Hongjia Zhang,Ah-Rim Lee,Ja-Hong Lee,김나은,박소연,이주현,함태호,권순욱 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.4
Pre-harvest sprouting (PHS) is one of the important traits that not only cause serious economic issues but also lead toreduction in grain quality and yield in rice (Oryza sativa L.). To analyze the quantitative trait loci (QTLs) for PHS tolerance, weevaluated PHS, seed dormancy (SD), and low-temperature germination (LTG) of 88 F2:3 populations and their parental lines. Genotypicanalysis was performed by using 441 single nucleotide polymorphisms (SNPs) detected from re-sequencing data. Seed dormancy (SD)and low-temperature germination (LTG) were identified to exhibit a positive correlation with PHS. Under the field condition, two majorQTLs for PHS, qPHS1-1FCand qPHS1-2FCwere identified on chromosome 1. Under the growth chamber condition, qPHS1-1GCandqPHS1-2GChad the same regions on chromosome 1. QTLs of SD and LTG (qSD1-1, qSD1-2, qLTG1-1, and qLTG1-2) had the sameregions; these results suggested that candidate QTLs demonstrate pleiotropy about PHS, SD, and LTG. The major QTLs detected in thisstudy are hypothesized to provide an important resource for molecular breeding and gain a better understanding of the genetics of traitsin rice.
Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
Lin, San-qing,Zhou, Zhong-liu,Zhang, Hua-lin,Yin, Wen-qing 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.5
Depression is the most common psychiatric comorbidity in patients. Searching for antidepressant drugs from natural products is very important for the treatment of this disease. The ethanol extract and its fractions of Cyperus rotundus were evaluated for antidepressant activities in mice by our group. The aim of this study was to investigate the potential active components of C. rotundus. The extraction and solvent partition of the rhizomes of C. rotundus, and repeated column chromatography for n-BuOH fraction yielded three new phenolic glycosides, rotunduside D (1), rotunduside E (2), and rotunduside F (3). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. The potential antidepressant activity of all the isolated compounds was evaluated. In the despair mice models, rotunduside F (3) showed significant antidepressant activity at the dosage of 50 mg/kg, which was close to the positive control fluoxetine (20 mg/kg).
Zi-Yi ZHANG,Yu-Ping ZHA,San-ShanCAI,Cheng-Hao HONG,Peng Liang,Jing-Yuan CHEN 한국곤충학회 2020 Entomological Research Vol.50 No.1
Monochamus alternatus (Hope) is a severe wood-boring pest in coniferous forests and a major vector of pine wilt disease in East Asia. Harmonic radar is a powerful tool for studying the dispersal behavior of insects and it could be applied to control pine wilt disease. In this study, we validated the application of harmonic radar for analyzing the dispersal behavior of M. alternatus beetles in a field environment. We determined the wing capacities of the beetles and the effects of electronic tagging and marking on their movement, flight ability, survivorship, and food consumption in the laboratory to confirm the suitability of this technique. The detection rate and recovery rate for beetles were analyzed separately using radar on caged pine stands and in the field environment. The results showed that the minimum wing capacity of the Japanese pine sawyer was 24.9 mg, which was seven times the weight of the electronic tag (3.5 mg). Marking and tagging the beetles had no significant adverse effects on their movement, flight capacity, food consumption, and survivorship. The detection rate using the radar system and recovery rate based on visual observations of the beetles in caged pines were both 95.6%. However, in the field environment, the detection and recovery rates were only 55.6% and 37.8% after one week, respectively, and 33.3% and 7.8% after two weeks. Harmonic radar is a promising technique for studying the dispersal behavior of the Japanese pine sawyer, but its performance is not satisfactory and major improvements are required for both the radar system and electronic tags.