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        Cross-Linked Poly(cyclotriphosphazene-co-phloretin) Microspheres and Their Application for Controlled Drug Delivery

        Sahid Mehmood,Haojie Yu,Li Wang,Md Alim Uddin,Bilal Ul Amin,Fazal Haq,Shah Fahad,Muhammad Haroon 한국고분자학회 2022 Macromolecular Research Vol.30 No.9

        In this work, cross-linked poly(cyclotriphosphazene-co-phloretin) (PCTPPT) microspheres were synthesized and characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscope (SEM). In FT-IR spectra, the new appeared bands at 1009 cm-1 and 1132 cm-1 confirmed the successful polymerization between hexachlorocyclotriphosphazene (HCCP) and phloretin (Pht). While the SEM results showed that the size of the microspheres was strongly dependent on the HCCP:Pht mole ratio. The crystalline nature of the PCTPPT microspheres was checked by X-ray diffraction (XRD) and provided evidence for the successful preparation of the microspheres. The thermal stability of the PCTPPT microspheres was investigated by thermogravimetric analysis (TGA). The obtained TGA results showed that the increase in thermal stability was attributed to the highly cross-linked covalently bonded structure of PCTPPT microspheres. The particle size distribution was determined by dynamic light scattering (DLS) and the results showed that the decreased HCCP:Pht mole ratio increases the size of the microspheres. The PCTPPT-3 microspheres were used as drug carriers for a model drug camptothecin (CPT). The experimental findings showed a cumulative release of 41.0% in pH 4.0 and 32.6% in pH 7.4 after 350 h and the PCTPPT-3/CPT microspheres have good drug loading capability and controlled release property for CPT.

      • SCOPUSKCI등재

        Synthesis of carboxymethyl starch grafted polyvinyl imidazole (CMS-g-PVIs) and their role as an absorbent for the removal of phenol

        Fazal Haq,Haojie Yu,Li Wang,Lisong Teng,Sahid Mehmood,Muhammad Haroon,Bilal-Ul-Amin,Shah Fahad,Md Alim Uddin,Di Shen 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.5

        Cigarette industry plays an important role in the economy of the advanced countries. But the cigarette smoke contains toxic chemicals such as phenol which causes various kind of diseases and affect human life. In this paper, we synthesized carboxymethyl starch grafted poly vinyl imidazole (CMS-g-PVIs) by reacting carboxymehtyl starch (CMS) with vinyl imidazole (VI). The structures of the CMS-g-PVIs were investigated by 1H NMR and FT-IR. The crystalline properties of the CMS and CMS-g-PVIs were checked by XRD. The thermal properties of the original CMS and CMS-g-PVIs were investigated by TGA analysis. It was found that the modified starches had high thermal stability due to aromatic imidazole ring. The modified starches also showed more rough and distorted morphology as compared to native CMS. The CMS-g-PVIs were subjected for phenol adsorption and showed adsorption efficiencies of 0.170 g/g, 0.190 g/g, 0.192 g/g and 0.199 g/g for CMS, CMS-g-PVI 1, CMS-g-PVI 2 and CMS-g-PVI 3, respectively. Due to higher grafting ratio, CMS-g-PVI 3 showed good adsorption efficiency of 0.199 g/g for phenol. The obtained results showed that the grafting of vinyl imidazole on CMS can increase the adsorption efficiency of native CMS towards phenol.

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