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RISS 인기검색어
- 검색키워드
- 저자 : Saeed Ghanbarzadeh (검색결과 3 건)
- 무료
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Preparation of optimized Naproxen nano liposomes using response surface methodology
Saeed Ghanbarzadeh,Sanam Arami,Arash Khorrami 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.1
The aim of this study was to prepare and optimizea liposomal delivery system for Naproxen (NPX), apractically water insoluble drug. NPX liposomes, whichwere consisted of cholesterol (CH) and phosphatidylcholine(PC) in different molar ratios, were prepared by modifiedethanol injection method and optimized employingresponse surface methodology (RSM). Proportion ofPC:CH and total lipid:drug ratio were selected as theindependent variables while the particle size (PS), encapsulationefficiency percent (EE%) and drug release of theliposomes over 24 h (D24h) were considered as dependentvariables. The effects of PC:CH and total lipid:drug ratioswere studied and optimized to obtain the liposomal vesicleswith desired quality. Graphical response surface and contourplots were also employed to understand the interactionof different variables. The optimum points for the variableswere obtained from the optimization plot. The mean PS,EE% and D24h of NPX liposomes were about 178.11 nm,53.14 and 46.62 % respectively. The results indicated thatPC:CH and total lipids:drug ratios were the major contributingvariables for EE% and D24h. However, only PC:CHratio was the main contributing variable for PS. The optimumformulation of NPX liposomes, in which PC:CH ratioand lipids:drug ratio were 3.81 and 2.98 respectively, hadhigh EE% (58 %) and D24h ([50 %) as well as appropriatePS (\162.4 nm). Ethanol injection method besides RSM,are simple, rapid and beneficial approaches for liposomepreparation and optimization.
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Simulation of nanosilver migration from polystyrene nanocomposite into food simulants
Soleimani, Jaber,Ghanbarzadeh, Babak,Dehgannya, Jalal,Islami, Sima Baheri,Sorouraddin, Saeed M. Techno-Press 2018 Advances in nano research Vol.6 No.3
Polystyrene granules were combined with nanosilver to form a nanocomposite film. One-side migration was conducted to test into three food simulants (3% acetic acid, 10% ethanol and 95% ethanol) at $40^{\circ}C$ temperature on different period of time (2, 4, 6, 8 and 10 days). It was found that, among the simulants, the highest migration amount was obtained with 3% acetic acid, while the 95% ethanol revealed the least migration level. Diffusion coefficients of nanosilver particles into simulants were estimated by inverse simulation using experimental data of concentration variation in the simulants. The finite element method used to solve the mass transfer equation and the numerical results indicates the sameresponse with the experimental data. The numerical results confirmed that the highest diffusion coefficient for acetic acid 3% (1.82E-10 to $1.76E-9m^2\;s^{-1}$) and the lowest diffusion coefficient for ethanol 95% from 2 to 10 days were obtained, respectively. Also, results of diffusion coefficient - concentration relation showed, the diffusion coefficient had in direct correlation with time and concentration. The results indicated that, in the 3% acetic acid, due to the increasing of diffusion coefficient of silver nanoparticles, they are released faster and distributed uniformly.
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Hadi Valizadeh,Parvin Zakeri-Milani,Peyman Nayyeri-Maleki,Saeed Ghanbarzadeh,Ahad Sheikhloo,Hossein Servat,Mahboob Nemati 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.1
The aim of this study was to evaluate thepharmacokinetics (PK) and bioequivalence (BE) of twometformin tablets. For in vitro evaluation, weight variation,assay and dissolution tests were performed. A randomized,single dose, two-period, cross over study in healthy malefasting volunteers was designed. A 2-week washout periodseparated the two periods. For analysis of PK parametersblood sampling was performed before and after drugadministration in various time points up to 12 h. Metforminconcentration in plasma was determined using a developedhigh performance liquid chromatography method. Bothformulations passed the assay, content uniformity, and dissolutiontests acceptance value. PK parameters, representingthe rate and the extent of metformin absorption were calculatedand analyzed for two formulations. The 90 % CIobtained by analysis of variance for the ratios of Cmax,AUC0–t, and AUC0–? were 92.14–110.95, 92.72–107.37and 89.42–110.23 % respectively, meeting the criteria forBE (80–125 %). Administration of a single dose of test andreference formulations did not result in statistically significantdifferences between in vitro and in vivo BE parametersin healthy Iranian male volunteers. Thus in the case of rateand extent of absorption the test and reference formulationswere considered bioequivalent.
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