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      • Biomedical Signal Transmission using OFDM-based Cognitive Radio for Wireless Healthcare Applications

        S. Mohandass,G. Umamaheswari 한국산학기술학회 2014 SmartCR Vol.4 No.3

        This paper describes an efficient design and implementation of orthogonal frequency division multiplexing-based Cognitive Radio to achieve the reliable transmission and reception of biomedical signals over a wireless channel. This concept can be used in wireless healthcare applications where medical information can be transferred through wireless networks for remote medical procedures or examinations. The main purpose of choosing Cognitive Radio is to efficiently utilize the available spectrum. As Cognitive Radio employs smart wireless devices with awareness, sensing, learning, and adaptation capabilities, it proves to be the best solution to solve the spectrum scarcity problem. Frequency bands that are not being used by the primary (licensed) users are utilized by Cognitive Radio users. The requirements of Cognitive Radios can be fulfilled largely by employing the orthogonal frequency division multiplexing technique. Using this technique, signals can easily be adapted to channel conditions and capacity requirements, which make it suitable for Cognitive Radio applications. The radio frequency spectrum utilization can be enhanced, and interference to other users can be minimized largely using orthogonal frequency division multiplexing-based Cognitive Radio. In this paper, we investigate the opportunistic access of the white space spectrum for healthcare applications. We propose a framework for the remote monitoring and analysis of patient health based on Cognitive Radio.

      • Protective effect of Asystasia gangetica reduced oxidative damage in the small intestine of streptozotocin-induced diabetic rats

        Kumar, K. Asok,Umamaheswari, M.,Sivashanmugam, A.T.,Subhadradevi, V.,Somanathan, S.S.,Ravi, T.K. Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.4

        Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6-phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.

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        Experimental animal models for diabetes and its related complications—a review

        Chidhambara Priya Dharshini Kottaisamy,Divya S. Raj,V. Prasanth Kumar,Umamaheswari Sankaran 한국실험동물학회 2021 Laboratory Animal Research Vol.37 No.3

        Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

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