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이원택,Sung Ho Lee,Sean G. Carriedo,Rona G. Giffard,Yeon Jung Yoon,Ji Hyung Kim,박경아,이종은 한국분자세포생물학회 2002 Molecules and cells Vol.14 No.2
The human papilloma virus-type 16 (HPV-16) E6 and E7 proteins interact with the p53 and pRb tumor sup-pressor proteins, respectively. The effect of E6 or E7 expression on UV irradiation (5 and 20 J/m2)-induced genotoxic injury of confluent primary murine astro-cytes was determined. Retroviral vectors were used to overexpress E6 and E7. Astrocytes expressing E7 showed increased vulnerability to UV-induced apop-tosis while E6 over expressing astrocytes were pro-tected from the same insults. Cell death in the E7 overexpressing cells was apoptotic because it showed DNA ladders, activation of caspase-3, formation of apoptotic bodies and decreased DNA content to less than the G0 level. After UV-irradiation the level of E2F1 in E7-expressing astrocytes was higher than E6-, LXSN- or mock-infected cells, and caspase-3 was acti-vated to a greater extent. E7-expressing astrocytes showed the highest levels of Bax under normal growth conditions. The mitochondrial membrane potential of E7-expressing astrocytes was depolarized by 90% af-ter UV-irradiation while the depolarization in control cells was about 50%. E6 overexpression decreased while E7 overexpression increased UV-induced astro-cyte apoptosis.
Direct protection of cultured neurons from ischemia-like injury by minocycline
Wendy C. Huang,Yanli Qiao,Lijun Xu,Rachid Kacimi,Xiaoyun Sun,Rona G. Giffard,Midori A. Yenari 대한해부학회 2010 Anatomy & Cell Biology Vol.43 No.4
Minocycline, a tetracycline antibiotic, is now known to protect cells via an anti-inflammatory mechanism. We further explored this effect using an in vitro model of ischemia-like injury to neurons. Coculturing neurons with microglia, the brain’s resident immune cell, modestly increased cell death due to oxygen and glucose deprivation (OGD), compared to neurons alone. Treatment of cocultures with minocycline decreased cell death to a level significantly lower than that of neurons alone. Treatment of cocultures with minocycline or inhibitors of various immune mediators, also led to decreased cell death. Importantly, treatment of neuron cultures without added microglia with these same inhibitors of tissue plasminogen activator, matrix metalloproteinases, TNF-alpha and inducible nitric oxide synthase as well as minocycline also led to decreased cell death. Thus, anti-inflammatory treatments appear to be directly protective of neurons from in vitro ischemia.