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- 저자 : Redditt, Thomas J. (검색결과 1 건)
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Redditt, Thomas J.,Chung, Eui-Hwan,Karimi, Hana Zand,Rodibaugh, Natalie,Zhang, Yixiang,Trinidad, Jonathan C.,Kim, Jin Hee,Zhou, Qian,Shen, Mingzhe,Dangl, Jeffery L.,Mackey, David,Innes, Roger W. American Society of Plant Biologists 2019 The Plant cell Vol.31 No.11
<P>The <I>Pseudomonas syringae</I> effector protein AvrRpm1 ADP ribosylates RIN4 proteins from Arabidopsis and soybean, which promotes association of RIN4 with EXO70E2 and suppression of callose deposition.</P><P>The <I>Pseudomonas syringae</I> effector protein AvrRpm1 activates the Arabidopsis (<I>Arabidopsis thaliana</I>) intracellular innate immune receptor protein RESISTANCE TO PSEUDOMONAS MACULICOLA1 (RPM1) via modification of a second Arabidopsis protein, RPM1-INTERACTING PROTEIN4 (<I>At</I>RIN4). Prior work has shown that AvrRpm1 induces phosphorylation of <I>At</I>RIN4, but homology modeling indicated that AvrRpm1 may be an ADP-ribosyl transferase. Here, we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean (<I>Glycine max</I>) within two highly conserved nitrate-induced (NOI) domains. It also ADP ribosylates at least 10 additional Arabidopsis NOI domain-containing proteins. The ADP-ribosylation activity of AvrRpm1 is required for subsequent phosphorylation on Thr-166 of <I>At</I>RIN4, an event that is necessary and sufficient for RPM1 activation. We also show that the C-terminal NOI domain of AtRIN4 interacts with the exocyst subunits EXO70B1, EXO70E1, EXO70E2, and EXO70F1. Mutation of either EXO70B1 or EXO70E2 inhibited secretion of callose induced by the bacterial flagellin-derived peptide flg22. Substitution of RIN4 Thr-166 with Asp enhanced the association of <I>At</I>RIN4 with EXO70E2, which we posit inhibits its callose deposition function. Collectively, these data indicate that AvrRpm1 ADP-ribosyl transferase activity contributes to virulence by promoting phosphorylation of RIN4 Thr-166, which inhibits the secretion of defense compounds by promoting the inhibitory association of RIN4 with EXO70 proteins.</P><P>[Figure]</P>
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