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Antibacterial properties of ferrimagnetic and superparamagnetic nanoparticles: a comparative study
Mohammadhossein Shahsavari Alavijeh,Milad Salimi Bani,Iman Rad,Shadie Hatamie,Mahsa Soufi Zomorod,Mohammad Haghpanahi 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2
In this study, antibacterial impact of magnetic nanocomposite (MNC: MoS2 /CoFe2O4) and super paramagnetic iron oxide nanoparticle (SPION: Fe3O4 -Casein) against staphylococcus aureus was studied. It was expected that such comparative study, address key points in optimization of synthesis and design of nanomaterials, which are supposed to be used as antibacterial agents for magnetic fluid hyperthermia (MFH) purposes. As the results, the MNC and SPION had average sizes of 17±4 nm and 15±5 nm, and diffused homogenously in agarose gel. They both were bacteriostatic against S. aureus at very low concentrations, while were bactericidal at concentrations of 200 µg/mL and more in MFH condition. In conclusion, both MNC and SPION inhibit S. aureus viability when low amplitude (H = 31.16 mT) alternative magnetic field (AMF: f = 150 kHz) was applied. Therefore, both of the nanomaterials are eligible to be considered as antibacterial candidates for treatment of complicated infections in upper respiratory tract or skin.
Mohammadhossein Shahsavari Alavijeh,Adel Maghsoudpour,Morteza Khayat,Iman Rad,Shadie Hatamie 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3
The aims were to characterize MoS 2 /CoFe 2 O 4 nanocomposite and investigate its thermal therapy efficiency on cancerous (MCF-7) and normal (MCF-10A) human breast cells. Magnetic nanocomposites (MNCs) characterized by scanning/transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM) techniques. TEM and SEM techniques showed MoS 2 /CoFe 2 O 4 MNCs had an average size of 17±4 nm with almost spherical morphology. Magnetic properties of MNC measured by VSM, which resulted in specific loss power (SLP) of 766.61 W/g at 300 K. Cytotoxicity of MoS 2 /CoFe 2 O 4 nanocomposites in MCF-7 and MCF-10A cell lines remained insignificant until 48 hours, which confirms its biocompatibility. Low concentration (200 µg/mL) of MoS 2 /CoFe 2 O 4 was exposed to the low-frequency alternative magnetic field (f = 150 kHz, H = 31.16 mT) in a way that delivery of thermal ablation via magnetic fluid hyperthermia (MFH) occurred exclusively in cancerous (MCF-7) cells.
Shahsavari Alavijeh Mohammadhossein,Maghsoudpour Adel,Khayat Morteza,Rad Iman,Hatamie Shadie 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.6
Purpose Aims were to investigate pattern of distribution of “molybdenum disulfide/cobalt ferrite” magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor. Methods MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors’ outer dimensions, histopathology and qRT-PCR assay techniques. Results Neither MoS2/ CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 μg/ml injected by speed rate of 10 μl/min to the tumor in the presence of AMF (f = 150 kHz, H = 31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected. Conclusion Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/ CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/ CoFe2O4 introduce it as a promising candidate for further clinical studies.