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Subhasmita Swain,Rabindra Nath Padhy,Tapash Ranjan Rautray 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.5
For fabricating the fi ller materials for tissue re-growth, the primary concern should be focused on the immunocompatibility of the material. Lymphocyte T-cells and macrophages activate each other and induce immune suppressive eff ects. Polarized hydroxyapatite–barium titanate composite surfaces showed comparatively less macrophage activity than unpolarized surfaces. Lymphocytes isolated from human umbilical cord blood were cultured separately on both polarized and unpolarized samples. The macrophage with nitric oxide and myeloperoxidase showed less activity on polarized composite surfaces as compared to lipopolysaccharide of stimulated cells from which it can be inferred that the polarized composites showed immunocompatibility for which these materials can be used a preferred material in tissue engineering applications.