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RISS 인기검색어
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- 저자 : Pingping Li (검색결과 21 건)
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Identification of MicroRNAs as potential biomarkers for detecting ischemic stroke
Li Kexin,Shen Li,Zheng Pingping,Wang Yanjun,Wang Lijuan,Meng Xiaoli,Lv Yaogai,Xue Zhiqiang,Guo Xin,Zhang Anning,Pan Pan,Bi Chunli,Chen Yang,Feng Tianyu,Li Bo,Jin Lina,Yao Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1
Background: Increasing epidemic of ischemic stroke (IS) makes it urgent to understand the pathogenesis and regulatory mechanism, previous studies have described microRNAs (miRNAs) is part of the brain's response to ischemia. Objective: The aim of this study was to screen potential biomarkers for the prediction and novel treatment of IS. Methods: Differentially expressed miRNAs were screened from three newly diagnosed IS patients and three controls by RNA sequencing technology. Furthermore, target prediction databases were then used to analysis the target genes of different expressed miRNAs, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database were used to identify the functions and the main biochemical and signal pathways of differentially expressed target genes. Results: Our results revealed that 27 miRNAs were differentially expressed in IS, among which, hsa-miR-659-5p was the most highly increased and was first found to be associated with IS. In addition, KEGG pathway analyses showed that differentially expressed miRNAs were mainly significantly enriched in lysosome pathway, cytokine-cytokine receptor interaction pathway, spliceosome pathway, base excision repair pathway. Conclusions: miRNAs were involved in IS pathogenesis, and hsa-miR-659-5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study.
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Pingping Li,Qiong Zhang,Tavonga Trevor Chadyagondo,Guoqing Li,Haihong Gu,Ni Li 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
In this research, non-fluorinated polyurethane/silica dioxide (PU/SiO2) nanofibrous webs were prepared byelectrospinning and hydrothermal treatment. Then the developed webs were laminated onto polyester woven fabrics toexamine their practical applications in the textile area. Investigation for surface morphology, pore size, water contact angle(WCA) and hydrostatic pressure was done in detail to examine the waterproofness and breathability of the PU/SiO2 nanofiberwebs and the laminated fabrics. The results showed that when Tetraethoxysilane concentration in electrospun solution was6 wt%, the fibrous web exhibited the desirable morphology, mechanical properties and hydrophobicity. At this time, SiO2nanoparticles dispersed uniformly on and in PU nanofibers and fibers had a more uniform diameter. The composite laminatedfabrics produced exhibited a value for hydrostatic pressure of 23.5 kPa with water vapor transmission rate (WVTR) of5.19 kg/m2/day.
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Cloud-based Full Homomorphic Encryption Algorithm by Gene Matching
Pingping Li,Feng Zhang 한국정보처리학회 2024 Journal of information processing systems Vol.20 No.4
To improve the security of gene information and the accuracy of matching, this paper designs a homomorphicencryption algorithm for gene matching based on cloud computing environment. Firstly, the gene sequences ofcloud files entered by users are collected, which are converted into binary code by binary function, so that theencrypted text is obviously different from the original text. After that, the binary code of genes in the databaseis compared with the generated code to complete gene matching. Experimental analysis indicates that when thenumber of fragments in a 1 GB gene file is 65, the minimum encryption time of the algorithm is 80.13 ms. Aside from that, the gene matching time and energy consumption of this algorithm are the least, which are85.69 ms and 237.89 J, respectively.
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Xing Lei,Li Yanqin,Li Wenhao,Liu Rong,Geng Yuanming,Ma Weiqun,Qiao Yu,Li Jianwen,Lv Yingtao,Fang Ying,Xu Pingping 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6
BACKGROUND: The study aims to correlate osteogenesis with autophagy during the mineralization induction of MC3T3-e1 through exploring the expression of runt-related transcription factor 2 (RUNX2)/lysosomal-associated transmembrane protein 5 (LAMPT5). METHODS: The induction of mineralization in MC3T3-e1 was followed by detecting the expressions of osteogenesisrelated indexes such as RUNX2, alkaline phosphatase (ALP), osteocalcin (OCN), and LAPTM5 using RT-qPCR and Western blot from 0 to 14 days. Transmission electron microscope was utilised in visualizing the alterations of autophagosomes, which was followed by immunofluorescence detecting the subcellular localization of autophagy-related index sequestosome 1 (P62) and microtubule-associated protein 1 light 3 (LC3) protein and scrutinising the expression of P62 mRNA and P62 and LC3 proteins. RESULTS: Induction of MC3T3-e1 mineralization demonstrated an increased expression of osteogenesis-related indicators such as RUNX2, ALP, OCN, and LAPTM5 (p\0.05), as evident from the results of RT-qPCR and Western blot. Meanwhile, the expression of autophagosomes increased one day after mineralization induction and then experienced a gradual decline, and enhanced expression of LC3 protein was noted on days 1–2 of mineralization induction but was then followed by a corresponding reduce. In contrast, a continuous increase was reported in the expression of P62 mRNA and protein, respectively (p\0.05). Up- and down-regulating RUNX2/LAPTM5 expression alone confirmed the aforementioned results. CONCLUSION: It was therefore proposed that RUNX2 may be responsible for an early increase and then a gradual decrease in LAPTM5-mediated autophagy through the regulation of its high expression. Meanwhile, increased LAPTM5 expression in osteogenic mineralization presumed that RUNX2/LAPTM5 promoted autophagy and osteogenic expression, which may play a bridging role in the regulation of autophagy and osteogenesis.
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Pingping Xie,Dongyuan Shi,Yinhong Li 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.2
Application of demand-side resources to automatic generation control (AGC) has a great significance for improving the dynamic control performance of power system frequency regulation. This paper investigates the possibility of providing regulation services by demand-side energy storage in electric vehicle battery swapping stations (BSS). An interaction framework, namely station-to-grid (S2G), is presented to integrate BSS energy storage into power grid for giving benefits to frequency regulation. The BSS can be regarded as a lumped battery energy storage station through S2G framework. A supplementary AGC method using demand-side BSS energy storage is developed considering the vehicle user demand of battery swapping. The effects to the AGC performance are evaluated through simulations by using a two-area interconnected power grid model with step and random load disturbance. The results show that the demand-side BSS can significantly suppress the frequency deviation and tie-line power fluctuations.
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Li Qian,Cai Pingping,Shen Baolong,Makino Akihiro,Inoue Akihisa 한국자기학회 2011 Journal of Magnetics Vol.16 No.4
In this study, we investigated the glass-forming ability (GFA) and magnetocaloric effect (MCE) of Gd55Co20Al23Si2 bulk glassy alloy. It is found that the addition of 2 at% Si is effective for extension of the supercooled liquid region (ΔTx), the ΔTx is 55 K for the Gd55Co20Al25 glassy alloy, and increases to 79 K for the Gd55Co20Al23Si2 alloy. As a result, Gd55Co20Al23Si2 glassy alloys with diameters up to 5 mm were successfully synthesized. The alloys also exhibit large MCE, i.e., the magnetic entropy change (ΔSm) of 8.9 J kg<SUP>?1</SUP> K<SUP>?1</SUP>, the full width at half maximum of the ΔSm (δTFWHM) of 87 K, and the refrigerant capacity (RC) of 774 J kg<SUP>?1</SUP>.
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Xie, Pingping,Shi, Dongyuan,Li, Yinhong The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.2
Application of demand-side resources to automatic generation control (AGC) has a great significance for improving the dynamic control performance of power system frequency regulation. This paper investigates the possibility of providing regulation services by demand-side energy storage in electric vehicle battery swapping stations (BSS). An interaction framework, namely station-to-grid (S2G), is presented to integrate BSS energy storage into power grid for giving benefits to frequency regulation. The BSS can be regarded as a lumped battery energy storage station through S2G framework. A supplementary AGC method using demand-side BSS energy storage is developed considering the vehicle user demand of battery swapping. The effects to the AGC performance are evaluated through simulations by using a two-area interconnected power grid model with step and random load disturbance. The results show that the demand-side BSS can significantly suppress the frequency deviation and tie-line power fluctuations.
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Ling Li,Pingping Zhuang,Ziqiang Cheng,Jie Yang,Jianmin Bi,Guihua Wang 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.3
Background: Coinfection with avian leukosis virus subgroup J (ALV-J) and reticuloendotheliosis virus (REV) is common in chickens, and the molecular mechanism of the synergistic pathogenic effects of the coinfection is not clear. Exosomes have been identified as new players in the pathogenesis of retroviruses. The different functions of exosomes depend on their cargo components. Objectives: The aim of this study was to investigate the function of co-regulation differentially expressed proteins in exosomes on coinfection of ALV-J and REV. Methods: Here, viral replication in CEF cells infected with ALV-J, REV or both was detected by immunofluorescence microscopy. Then, we analyzed the exosomes isolated from supernatants of chicken embryo fibroblast (CEF) cells single infected and coinfected with ALV-J and REV by mass spectrometry. KEGG pathway enrichment analyzed the co-regulation differentially expressed proteins in exosomes. Next, we silenced and overexpressed tripartite motif containing 62 (TRIM62) to evaluate the effects of TRIM62 on viral replication and the expression levels of NCK-association proteins 1 (NCKAP1) and actin-related 2/3 complex subunit 5 (ARPC5) determined by quantitative reverse transcription polymerase chain reaction. Results: The results showed that coinfection of ALV-J and REV promoted the replication of each other. Thirty proteins, including TRIM62, NCK-association proteins 1 (NCKAP1, also known as Nap125), and Arp2/3-5, ARPC5, were identified. NCKAP1 and ARPC5 were involved in the actin cytoskeleton pathway. TRIM62 negatively regulated viral replication and that the inhibition of REV was more significant than that on ALV-J in CEF cells coinfected with TRIM62. In addition, TRIM62 decreased the expression of NCKAP1 and increased the expression of ARPC5 in coinfected CEF cells. Conclusions: Collectively, our results indicated that coinfection with ALV-J and REV competitively promoted each other's replication, the actin cytoskeleton played an important role in the coinfection mechanism, and TRIM62 regulated the actin cytoskeleton.
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