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RISS 인기검색어
- 검색키워드
- 저자 : Pielak, Rafal M. (검색결과 2 건)
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Heo, Seung Yun,Kim, Jeonghyun,Gutruf, Philipp,Banks, Anthony,Wei, Pinghung,Pielak, Rafal,Balooch, Guive,Shi, Yunzhou,Araki, Hitoshi,Rollo, Derrick,Gaede, Carey,Patel, Manish,Kwak, Jean Won,Peñ,a American Association for the Advancement of Scienc 2018 Science Translational Medicine Vol.10 No.470
<P>Exposure to electromagnetic radiation can have a profound impact on human health. Ultraviolet (UV) radiation from the sun causes skin cancer. Blue light affects the body’s circadian melatonin rhythm. At the same time, electromagnetic radiation in controlled quantities has beneficial use. UV light treats various inflammatory skin conditions, and blue light phototherapy is the standard of care for neonatal jaundice. Although quantitative measurements of exposure in these contexts are important, current systems have limited applicability outside of laboratories because of an unfavorable set of factors in bulk, weight, cost, and accuracy. We present optical metrology approaches, optoelectronic designs, and wireless modes of operation that serve as the basis for miniature, low-cost, and battery-free devices for precise dosimetry at multiple wavelengths. These platforms use a system on a chip with near-field communication functionality, a radio frequency antenna, photodiodes, supercapacitors, and a transistor to exploit a continuous accumulation mechanism for measurement. Experimental and computational studies of the individual components, the collective systems, and the performance parameters highlight the operating principles and design considerations. Evaluations on human participants monitored solar UV exposure during outdoor activities, captured instantaneous and cumulative exposure during blue light phototherapy in neonatal intensive care units, and tracked light illumination for seasonal affective disorder phototherapy. Versatile applications of this dosimetry platform provide means for consumers and medical providers to modulate light exposure across the electromagnetic spectrum in a way that can both reduce risks in the context of excessive exposure and optimize benefits in the context of phototherapy.</P>
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A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
Koh, Ahyeon,Kang, Daeshik,Xue, Yeguang,Lee, Seungmin,Pielak, Rafal M.,Kim, Jeonghyun,Hwang, Taehwan,Min, Seunghwan,Banks, Anthony,Bastien, Philippe,Manco, Megan C.,Wang, Liang,Ammann, Kaitlyn R.,Jang, American Association for the Advancement of Scienc 2016 Science Translational Medicine Vol.8 No.366
<P>Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation. This integration defines access points for a small set of sweat glands such that perspiration spontaneously initiates routing of sweat through a microfluidic network and set of reservoirs. Embedded chemical analyses respond in colorimetric fashion to markers such as chloride and hydronium ions, glucose, and lactate. Wireless interfaces to digital image capture hardware serve as a means for quantitation. Human studies demonstrated the functionality of this microfluidic device during fitness cycling in a controlled environment and during long-distance bicycle racing in arid, outdoor conditions. The results include quantitative values for sweat rate, total sweat loss, pH, and concentration of chloride and lactate.</P>
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