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RISS 인기검색어
- 검색키워드
- 저자 : Paramasivam Gokul (검색결과 2 건)
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Synthesis of an antibiotic-preserving antimicrobial tetracycline-loaded gellan gum gel
Paramasivam Gokul,Dhamodharan Duraisami,Kishore Somasundaram Chandra,변헌수 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.9
Gels play a significant role in our daily lives as they provide stability and desired features to various items of regular use, such as cosmetics, pharmaceuticals, household items, and agricultural products. However, a microbial attack on gels commonly occurs during gel-based formulations. Antibiotic-loaded gels can reportedly be stored for a long time. In this study, we fabricated a tetracycline-loaded gellan gum (TC/GG) gel and assessed its long-term stability against microbial attack. Morphological analyses revealed a firm and smooth texture with multifold bumpy surfaces on the GG and TC/GG gels. Fourier transform infrared spectroscopic analysis showed that the gel was well hydrated and thus suitable for releasing antibiotics. The feasibility of inhibiting microorganisms was qualitatively examined using the disk diffusion method. Interestingly, the unloaded GG gel itself exhibited an antimicrobial effect, while the loaded TC/GG gel showed a better antibacterial effect on S. aureus than on E. coli. TC/GG can be used to store and protect gels from microbial attacks for a long duration. In addition, it is suitable for storing bioactive agents, which are used in the biomedical field.
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Paramasivam Gokul,Dhamodharan Duraisami,변헌수 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.3
Gels are widely used in our everyday lives, spanning personal care, cosmetics, oral care, food and beverages, household products, medical supplies, electronics, and arts and crafts. Their adaptable characteristics contribute to improved product performance, user satisfaction, and overall convenience. However, generation of microbial invasion is a common obstacle observed on gels and its formulations. Antibiotic loaded on gels is a better alternative to chemical-based preservative for long-term storage of gels. In this research, the gel was fabricated with two diff erent components with guar gum (GU) and tetracycline (TC) and its antimicrobial ability was tested over a period of time. We conducted morphological analyses that revealed a solid and rough surface on both GU and reduced sign of microbial attack on TC/GU-based gels. Identifi cation of functional groups is observed using Fourier transform infrared (FTIR) spectroscopy that confi rms the gel is well hydrated and make it suitable to deliver antimicrobial agents. Antimicrobial ability performed by antibiotics was tested using disc diff usion method. The unloaded GU gel does not exhibit an observed antimicrobial property, whereas GU/TC gel reveals a better antibacterial effi ciency on S. aureus compared to E. coli . Our fi ndings suggest that GU/TC gel can eff ectively safeguard gels from microbial attacks during long-term storage. Furthermore, this GU/TC gel can be used as a drug transport system for bioactive agents in biomedical applications.
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