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Dorcas Ibukun Akinloye,Olatunbosun Samuel Sojinu,Regina Ngozi Ugbaja,Samuel Agemo,Moses Oluwasegun Akintubuwa,Tolulope Julius Bolaji 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.2
Acalypha wilkesiana godseffiana Mull arg leaf is traditionally used among Yorubas in Southern Nigeria for the treatment of malaria, dermatological disorders, gastrointestinal disorders and diabetes mellitus. It has also been reported to have in vitro antioxidant capacities. This study accessed the mitigating effects of Acalypha wilkesiana godseffiana ethanol extract (EEAW) against CCl4-induced oxidative impairment using specific activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and levels of glutathione (GSH), vitamin C (Vit. C), malonialdehyde (MDA), nitric oxide (NO), percentage DNA fragmentation as well as immunohistochemical expression of the cytoplasmic expression of p38, p16 and p53 proteins as bio-markers. Induction of oxidative damage in female wistar rats were done by intraperitoneal injection of 1 ml.kg−1 body weight of CCl4 (50% v/v using Olive oil as vehicle). Administration of the EEAW ameliorated CCl4-induced oxidative impairment by up-regulating p16 with concomitant down-regulation of p38 and p53 protein expressions. Serum concentration of GSH and vitamin C was significantly increased when compared to the CCl4-intoxicated group. The decrease in the specific activities of SOD, CAT, GPx, GR as well as increase in levels of MDA, NO and percentage DNA fragmentation induced by CCl4-intoxication were significantly mitigated by the extract treatment. These findings indicated that EEAW possesses some mitigating effects against CCl4-induced oxidative impairment.