GIS기반 동남 광역권 산업체 정보시스템 구축 및 활용

남광우 ( Kwang Woo Nam ),권일화 ( Il Hwa Kwon ),박준호 ( Jun Ho Park ) 한국지리정보학회 2014 한국지리정보학회지 Vol.17 No.1

Following the technology developments of traffic network and communication for the wide area, the importance of the cooperation system to vitalize the wide area economy is increasing. Therefore, in this study, DongNam Kwon industry information system is established for the industrial information sharing based on GIS in the DongNam Kwon wide area economy. The DongNam Kwon is an industrial integration area centered with the manufacturing so that the operation of effective industrial cluster and cooperation systems are required across the administrational boundaries. To establish the database of the information, the information system was established utilizing already established industrial databases in Busan, Ulsan and Gyeongnam. But, various issues caused by the discordances among the data of each local government and the insufficiency of GIS based location information have been found. According to the analysis, the standardization considering the courses of collection, distributions and utilization are required immediately to solve the issues. This study establishes an 2-way industrial information system enabling the information creation and the phased approach between the administrator and the user in the bi-directions on the web by utilizing cadastral and numerical maps. The result of this study would have a meaning in providing a fundamental frame for cooperative responses and cooperation system for DongNam Kwon``s industrial promotion using industrial information sharing.

A rare case of miliary tuberculosis accompanying perihepatitis

Ou Jun Kwon1,이석우,장문순,김상철,이지한,김훈 대한응급의학회 2019 Clinical and Experimental Emergency Medicine Vol.6 No.3

Perihepatic capsulitis is associated with various diseases, such as Fitz-Hugh-Curtis syndrome, systemic lupus erythematosus, perforated cholecystitis, perforated hepatic abscess, and tuberculous peritonitis. Miliary tuberculosis is present in about 2% of all reported cases of tuberculosis and is characterized by the widespread millet-like hematogenous dissemination of Mycobacterium tuberculosis. We describe a 24-year-old virgin patient presenting with right upper quadrant and costovertebral angle pain. Diffuse perihepatic capsular enhancement was observed in abdominal computed tomography scans. Chest radiography showed miliary tuberculosis, and a polymerase chain reaction hybridization assay of sputum revealed the presence of M. tuberculosis. Symptoms improved after administering anti-tuberculosis medications. This report describes a rare case of miliary tuberculosis accompanying perihepatitis.

니코틴 대사와 CYP2A6 유전자 빈도에 관한 민족적 다형성

권준택 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

사람의 CYP2A6 유전자는 CYP2A6*1A, CYP2A6*1B, CYP2A6*2, CYP2A6*3, CYP2A6*4 및 CYP2A6*5 대립 유전자가 밝혀져 있으며, nicotine-C 산화반응을 촉매하고 있다. 앞선 보고에 의하면, 일본인에서 nicotine 대사의 개인간 차이는 CYP2A6 유전자 다형성 (genetic polymorphism)과 관련이 있음이 증명된 바 있다. 저자는 Nicotine대사와 CYP2A6 대립 유전자들의 빈도에서 인종간의 차이를 증명하기 위해 209예의 한국인에서 nicotine대사와 CYP2A6의 유전자형을 연구하였다. Nicotine 껌을 투여 후 2시간에 혈장 cotinine/nicotine 비를 계산하여 nicotine대사의 지표로 사용하였으며, CYP2A6의 유전자형은 PCR-RFLP방법으로 결정하였다. 실험 결과 CYP2A6*1A, CYP2A6*1B, CYP2A6*4 및 CYP2A6*5 대립 유전자의 빈도는 한국인 (각각 45.7%, 42.8%, 11.0% 및 0.5%)과 일본인간에는 인종간의 차이를 보였다. 그러나 CYP2A6*2와 CYP2A6*3 대립 유전자형에는 어떠한 차이도 관찰할 수 없었다. 4명의 CYP2A6*4 homozygotes에서는 cotinine형성이 완전히 결여되었으며 그 결과는 일본인에서 관찰된 자료와 일치하였다. CYP2A6*4 heterozygotes에서는 이것이 없는 사람들에 비해 낮은 대사율을 보이는 경향이 있었으며, CYP2A6*1B 대립유전자를 지닌 사람들은 cotinine 형성 능력이 훨씬 높은 경향을 나타내었다. 니코틴 대사의 개인별 차이는 CYP2A6의 유전자 다형과 밀접한 관련이 있음을 확인하였다. 한국인에서 대사율의 probit plot 결과는 0.6의 antimode치를 보여 일본인에서 얻은 결과와 동일하였다. CYP2A6*1B/CYP2A6*4를 가진 한 명의 한국인에서 새로운 CYP2A6 돌연변이가 있는 것으로 보였다. 한국인의 probit plot 결과는 일본인보다 높은 비를 보였으며, 각 유전자형 군에서 한국인 군은 일본인 군에 비하여 유의하게 높은 대사율을 보였다. Cotinine 형성에서 인종간의 차이는 유전학적 소인 외에도 환경인자 및 식이 등의 인자들이 관여할 것으로 보인다.

[18F]FDG PET을 이용한 강박증 환자에서 뇌 포도당 대사의 이상에 관한 연구

권준수,이동우,이재성,최정임,이동수,정준기,조맹제,이명철,류인균 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 강박증에 대한 기능적 뇌영상 연구들에서 강박증 환자들의 안와전두엽과 미상핵의 대사율 증가 소견이 비교적 일과되게 발표되어 왔으며, 전두-피질하 회로의 이상이라는 이론이 수립되기도 하였다. 그러나 기존의 연구들은 강박증의 유병기간에 따른 구분없이 시행된 연구였고, 영상분석 방법에 있어서도 관심영역 방법을 이용했다는 한계를 지니고 있다. 본 연구의 목적은 첫째, 강박증의 유병기간에 따라 환자군을 구분하여 PET 영상소견을 분석함으로써 유병 기간에 따른 차이가 있는지를 조사하였으며, 둘째, 강바증 환자의 포도당 양전자방출 단층촬영(18-Fluor-deoxyglucose Positron Emission Tomography : FDG-PET) 영상분석에 통계적 매개변수 지도법(Statistical Parametric Mapping : SPM)을 이용함으로써 강박증의 병인기전 및 강박증상과 뇌기능 간의 관계를 명확히 규명하고자 하였다. 방법: 구조적 면담도구(Structured clinical interview for DSM-IV : SCID-IV)를 적용하여 진단된 12명의 강박증 환자들과 10명의 정상 대조군에 대해 FDG-PET을 촬영하여 SPM으로 분석하였다. PET 촬영 전 적어도 4주 동안에는 약물복용을 하지 않은 상태였다. 결과: 1) 환자군과 대조군의 비교 : 강박증 환자군은 대조군에 비해 양측 두정 영역의 대사율이 유의하게 감소되어 있었으며(P<0.01). 대사증가를 보인 영역은 없었다. 강박증의 유병기간이 10년 이상인 만성강박증 환자 4명은 양측 안와전두엽에서 유의한 대사증가 소견을 보였으며(P<0.01), 양측 두정영역에서 유의한 대사감소 소견을 보였다 (P<0.01), 유병기간이 10년 이하인 환자에서는 전체 환자군의 분석에서와 마찬가지로 대조군에 비해 유의한 대사증가 소견을 보인 영역은 없었으며, 양측 두정엽 부위에서 유 의한 대사 감소 소견을 보였다.(P<0.01). 2) 강박증상의 심각도와의 상관관계 분석 : 우측 두정엽의 대사율은 강박장애 척도 점수와 유의한 음의 상관관계를 보였으며(p<0.01), 양측 시상 영역의 대사율은 예일-브라운 강박장애 척도의 강박장애척도 점수와 유의한 양의 상관관계(p<0.01)를 보였다. 결론: 본 연구는 결과는 기존의 연구들에서 보고된 안와전두엽의 대사 증가 소견이 강박증의 만성화로 인해 나타나는 2차적 장애이며, 두정엽의 대사 저하가 보다 1차적인 장애일 가능성을 시사한다. Baxter가 수립한 전두-피질하 회로 이론은 두정엽의 이상을 포함하는 전두-두정엽 복합체 이론으로 확장되어야 할 것이다. Objectives: Functional imaging studies on obsessive-compulsive disorder(OCD) subjects have repeatedly reported increased metabolism in orbitofrontal lobes and caudate nucleus, resulting in the "frontal-subcortical" circuit abnormality theory. Limitations of the previous studies to date include little consideration for the duration of illness, and the use of regions of interest methods, as an image analysis method. Our study objectives are 1) to include the duration of illness as an important study variable, and 2) to use Statistical Parametric Mapping(SPM) method in order to tap relations between the brain function and the psychopathology and symptoms of OCD. Methods: The [18] fluorodeoxyglucose positron emission tomography(FDG-PET) scans of OCD subjects and normal comparison subjects, as diagnosed by the Structured Clinical Interview for DSM-IV(SCID-IV), were analyzed using SPM. Results: 1) Comparison of OCD and control groups : OCD subjects had significantly decreased metabolism in both parietal lobes and didn't have any areas of increased metabolism in comparison to comparison subjects(p.<0.01). four OCD subjects with the illness duration of 10 years or longer, had significantly increased metabolism in both orbitofrontal lobes<p<0.01). OCD subjects whose illness duration is shorter than 10 years didn't have any areas of increased metabolism and had significantly decreased parietal lobe metabolism, as in the analyses of all subjects(p<0.01). 2) Correlation analysis between areas and symptom severity : Metabolism of both thalamic sreas showed significant positive correlation with Yale-Brown Obsessive-Compulsive Scale(Y-BOCS) scores(p<0.01). Metabolism of right parietal area showed significant negative corre lation with Y-BOCS scores(p<0.01). Conclusions: The current findings suggest that the increased metabolism in orbitofrontal lobe, previously rported, may be a secondary phenomenon due to the extended illness dur- ation and that decreased metabolism in the parietal lobes are primary abnormality in OCD subjects. Thus Baxter's fronto-subcortical circuit theory should be extended into "fronto-pari-etal" complex theory, which includes the parietal lobes.

단백뇨를 보이는 사구체 질환 및 당뇨병성 신병증에서의 Lp(a)

권태환,김준홍,조성,김석재,김용림,조동규,백미영 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Background: Recently there has been evidences that serum Lp(a), an independent risk factor to atherosclerotic cardiovascular diseases, were increased in proteinuric disorders such as nephrotic syndrome and diabetic nephropathy. Methods: We intended to search of altered concentrations of Lp(a) in proteinuric disorder measuring serum Lp(a) concentrations with ELISA in 44 glomerulonephritic patients(25 nephrotic syndrome(NS), 19 non-nephrotic range proteinuric glomerulonephritis(GN), 25 diabetic nephropathy patients(DN), and 31 healthy controls(HC). Also, we compared Lp(a) concentration between glomerulonephritis patients and diabetic nephropathy patients with proteinuria of similar degree. Results: 1) There were significantly increased levels of total choesterol, triglyceride, and LDL-cholesterol in Ns compared to GN, DN, HC. 2) There were significantly increased concentrations of serum Lp(a) in NS compared to HC, but no signiicant difference in serum Lp(a) among NS, GN, and DN. 3) There was no significant difference in serum Lp(a) concentrations between NS & DN with 24 hour urine protein greater than 3.0g. 4) There was no significant difference in serum Lp(a) concentration between GN with 24 hour urine protein greater than 0.5g and less than 1.5g and DN with proteinuria of simial degree. 5) In glomerulonephritis patients, there was negative correlation between serum Lp(a) concentration and serum albumin level but correlation with 24 hour urinary protein, total cholesterol, Ldl-cholesterol, and HDL-cholesterol was not shown. In diabetic nephropathy, there was no significant correlation among serum Lp(a) concentration and all parameters including serum albumin, 24 hour urinary protein, and other lipid profiles. Conclusion: The present study confirmed that patients with nephrotic syndrome of diverse etiologies have makedly increased plasma level of Lp(a), in conjunction with other lipid abnormalities. However, this study shows no difference in Lp(a) concentrations between diabetic nephropathy and glomerulonephritis with similar degree of proteinuria.

이동전화 단말기 판매보조금 실태조사 연구

권준식 世明大學校 1998 世明論叢 Vol.7 No.-

In this paper, to propose the healthy policy for the good mobild communication service. I researched an actual state of the mobile telephone sale subsidy and subscribers of cellular and PCS companies. I investigated the present conditions of mobile communicaion service and the point at issue, and propose the desirable strategies such as the improvement of call quality through a network construction and added service expansion and the healthy strategy such as the removal of obligaiton subscription term and the reduction of call fee.

공정변수의 변동을 고려한 호감도 함수를 통한 다중반응표면 최적화

권준범,이종석,이상호,전치혁,김광재 한국경영과학회 2005 한국경영과학회지 Vol.30 No.1

A desirability function approach to a multiresponse problem is proposed considering process parameter fluctuation which may amplify the variance of response. It is called POE(propagation of error), which is defined as the standard deviation of the transmitted variability in the response as a function of process parameters. In order to obtain more robust process parameter setting, a new desirability function is proposed by considering POE as well as distance-to-target of response and variance. The proposed method is illustrated using a rubber product case in Ribeiro et al. (2000).

다시점 영상 방송을 위한 플레이어 모델의 설계 및 구현

권준섭,김만배,최창열 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

With the rapid development of computing technology, multi-view video is attracting extensive interest recently due to its greatly enhanced viewing experience. In this paper, we propose an integrated display solution model and present the prototype system for multi-view video. The player can display and verify the multi-view video. For verifying the accuracy of synthesizing graphics, it can display in both 2D and 3D mode, and save frames into various format. And, in experiments we can select not only degree of stereoscopic effect but also number of intermediate views between real cameras. With this system, users are able to select their desired viewing directions and enjoy many exciting visual experiences, such as view switching, freeze and rotate and view sweeping, with great freedom.

명상에 의한 뇌파의 변화 : 스펙트럼 분석 및 시각적 고찰

권준수,함봉진,이부영 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

목적 : 본 연구는 한국의 전통적인 명상법의 하나인 단학수행에 의한 뇌파의 변화를 조사하기 위한 것이다. 방법 : 명상수행자 16명과 대조군 9명을 모집하였다. 명상 및 이완상태에서 측정한 뇌파에 대한 스펙트럼 분석을 시행하여 각 주파수 구간의 절대력(absolute power)과 양반구간 동시성(interhemispheric coherence)을 구하였다. 명상수행군과 대조군의 뇌파변화를 비교하기 위하여, 절대력과 양반구간 동시성의 변화율을 계산하였다. 아울러, 스펙트럼 분석으로 발견되지 않는 뇌파의 특징을 조사하기 위하여 모든 뇌파를 시각적으로 관찰하였다. 결과 : 11명의 명상수행자와 4명의 대조군이 졸음 또는 순응도 불량으로 분석에서 제외되었고, 명상 수행자 5명과 대조군 5명이 실제 분석에 포함되었다. 명상수행군과 대조군 모두 다양한 뇌파의 변화를 보였고, 그 변화의 정도는 대조군에 비해 명상수행군에서 현저하였다. 이러한 차이는 전두엽부위의 알파와 쎄타의 절대력과 베타의 양반구간 동시성 그리고 후두엽부위의 쎄타의 양반구간 동시성에서 현저하였다. 대조군에 비해 명상수행군에서 전두엽부위의 알파와 쎄타의 절대력과 후두엽 부위의 쎄타의 양반구간 동시성이 증가하는 경향이 있었다. 뇌파의 시각적 관찰에서 5명의 명상수행군 중 3명에서 많은 theta burst가 발견되었고, 대조군에서는 1명에서 1개의 theta burst가 나타났다. 결론 : 이상의 결과는 뇌파변화의 다양성과 theta burst의 출현이 대조군과 구별되는 명상수행군의 특징이고, 명상의 상태가 단순한 이완상태에 비해 매우 다양하고 역동적이라는 것을 시사한다. 0bjectives : This study was to investigate the EEG changes induced by Danhak which is one of the Korean traditional meditation. Methods : Sixteen meditators and 9 controls were recruited. Spectral analysis and visual inspection of EEG during meditation(meditators) and relaxation(controls) were performed. The absolute power and interhemispheric coherence in each frequency band were obtained. Ratio of change in absolute power and interhemispheric coherence was calculated to compare the EEG changes between meditators and controls. To evaluate episodic changes of EEG with time, all recorded EEGs were reviewed by visual inspection. Results : Eleven meditators and 4 controls were excluded from the analysis due to drowsiness or poor compliance. Both meditators and controls showed various EEG changes and the degree of variability was more prominent in meditators than in controls. These differences were evident in absolute power of alpha and theta and coherence of beta at frontal, and coherence of theta at occipital. Meditators showed the increase in absolute power of alpha and theta at frontal, and interhemispheric coherence of theta at occipital. In visual inspection, a number of theta bursts were observed in three of 5 meditators and only one theta burst appeared in one control. Conclusion : These results suggest that great variability of EEG change and the appearance of the bursts is the characteristics of EEG change and the appearance of theta bursts is the characteristics of EEG changes of meditators and that th state of meditation is more diverse and than that of relaxation.

어류의 패내 산란과 석패과 유생의 어체부착

권오길,박갑만,이준상,송호복 江原大學校 附設 環境硏究所 1991 環境硏究 Vol.8 No.-

This study was carried out to determine the attachment parts and rates on the host fish and the successive stages of the glochidial encystment. A scanning electron microscope observation of the glochidia, the larvae of freshwater brivalve, Anodonta arcaeformis flavotincta, on the host fish, Carassius auratus, was conducted. The attachment rates on the host fish were 30.1%, 22.3% on the pectoral, the caudal, and the pelvic and anal fin, respectively. Glochidia, once attached to the host, have become encysted within 27 hours. The glochidia in fish tissues have sloughed between 13 days and 15 days when the water temperature was 16℃ in laboratory. During encystment, the epithelial cells of the host fish migrated actively toward the attached glochidia and covered them. In the encystment process, the encysted tissues in the host have become loose in seven days and exposured a pat of the glochidium in eight days after infection. No changes of the glochidial size have found before attachment and after sloughing.